Issue 48 of OBC is now online; the last issue of 2012!
Front cover:
Anyone for a game of dominos? In this paper Alessandro Volonterio and colleagues report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins. Volonterio et al. believe that this methodology is especially convenient for the synthesis of spiro-hydantoins, which are particularly interesting bioactive compounds in medicinal chemistry.
Regioselective multicomponent sequential synthesis of hydantoins
Francesca Olimpieri, Maria Cristina Bellucci, Tommaso Marcelli and Alessandro Volonterio
DOI: 10.1039/C2OB26498F
Inside cover:
This colourful cover highlights the work of Atul Goel & Gerhard Bringmann et al., who report a short and efficient synthesis of racemic cis-pterocarpans and highlight a new protocol for the resolution of the enantiomers on a chiral phase through analytical and preparative HPLC.
Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans
Atul Goel, Amit Kumar, Yasmin Hemberger, Ashutosh Raghuvanshi, Ram Jeet, Govind Tiwari, Michael Knauer, Jyoti Kureel, Anuj K. Singh, Abnish Gautam, Ritu Trivedi, Divya Singh and Gerhard Bringmann
DOI: 10.1039/C2OB25722J
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