Scientists in France and Lebanon had previously synthesised and evaluated the biological properties of a series of 1,1-diarylethylene analogues of isocombretastatin A-4, which is related to the natural combretastatin A-4, an antitumour agent. Now, they have studied the effects of structural modifications on the linker between the two aromatic rings of the isocombretastatin A-4 to better understand the structure-activity relationships associated with this series of 1,1-diarylethylene tubulin polymerisation inhibitors. The new compounds exhibit potent cytotoxicity against cancer cell lines.
Organic: Anticancer compound’s analogues exhibit potent cytotoxicity against cancer cell lines
Abdallah Hamze and Mouad Alami
Org. Biomol. Chem., 2012,