Electrophilic cyclisations is an area of chemistry that is continually and rapidly growing and expanding. This Emerging area from Adeline Palisse and Stefan F. Kirsch, University of Wuppertal, highlights the recent progress in C–C bond-forming halocyclisations allowing the reaction of alkynes with carbon-nucleophiles.
Palisse and Kirsch focus on iodine electrophiles, and aim to show that these iodocyclisations with alkynes have become a very useful strategy to construct structures. The review is roughly split into three major categories:
1) malonates as nucleophilic
2) arene nucleophiles
3) olefins as nucleophiles
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Metal-free reactions of alkynes via electrophilic iodocarbocyclizations
Adeline Palisse and Stefan F. Kirsch