This week’s OBC cover highlights the work of Aurelio Hidalgoand co-workers at the Center for Molecular Biology, whose paper describes the promiscuous enantioselective (−)-γ-lactamase activity in Pseudomonas fluorescensesterase I. In the paper Aurelio Hidalgoet al. show how the introduction of a mutation to the wild esterase improved the reaction turnover without affecting the enantioselectivity. Read the paper to find out more…..
This paper is FREE to access for the next 6 weeks, so why not take a look at it.
Promiscuous enantioselective (−)-γ-lactamase activity in the Pseudomonas fluorescensesterase I
Leticia L. Torres, Anna Schließmann, Marlen Schmidt, Noella Silva-Martin, Juan A. Hermoso, José Berenguer, Uwe T. Bornscheuer and Aurelio Hidalgo
Org. Biomol. Chem., 2012, 10, 3388-3392
DOI: 10.1039/C2OB06887G
Also in this issue:
| A review:
Making expensive dirhodium(II) catalysts cheaper: Rh(II) recycling methods A HOT article: Copper-mediated domino synthesis of pyrimido[4,5-b]carbazolones via Ullmann N-arylation and aerobic oxidative C–H amidation |
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