Asymmetric catalytic Mannich-type reaction of hydrazones using Zn(II) complexes on the cover of OBC issue 13

The cover of this week’s OBC features work from Min Shi et al. at Shanghai Institute of Organic Chemistry and Texas Tech University, who have used chiral zinc(II)–imidazoline–phosphine complexes in a novel catalytic system for the asymmetric Mannich-type difluorination of hydrazones with difluoroenoxysilanes.

Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand–zinc(II) complexes
Zhiliang Yuan, Liangyong Mei, Yin Wei, Min Shi, Padmanabha V. Kattamuri, Patrick McDowell and Guigen Li
Org. Biomol. Chem., 2012, 10, 2509-2513
DOI: 10.1039/C2OB07022G

Read the full Communication; it is FREE to access for the next 6 weeks.

This issue also contains:

A Perspective review article: On a so-called “kinetic anomeric effect” in chemical glycosylation, by Ian Cumpstey

as well as the HOT article:

Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked β-N-acetylglucosaminyl-6-phosphate modification
Mark E. Graham, Robin S. Stone, Phillip J. Robinson and Richard J. Payne

If you liked these why not have a look at the rest of the issue here

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