Welcome to Issue 3! On the front cover we have work from Lucio Pellacani and colleagues on their one-pot method to α-substituted nitro alkenes. They devised a domino condensation-dehydration process to give α-nitro acrylates or cinnamates, α-nitro α,β-unsaturated ketones and aromatic and heteroaromatic (E)-2-nitro allylic alcohols, compounds with anticancer activity, in high yields and high diastereomeric purity which has not previously been achieved.
Domino reactions for the synthesis of various α-substituted nitro alkenes
Stefania Fioravanti, Lucio Pellacani and Maria Cecilia Vergari
DOI: 10.1039/C1OB06260C
As with all our cover articles, this one is free to access for 6 weeks – so why not take a look?
