‘While methods of electrophilic fluorination have been extensively developed to stereoselectively install fluorine atoms onto molecules, nucleophilic fluorination is a much less explored approach’, explains Associate Professor Choon-Hong Tan, from National University of Singapore.
In this concise review article, Choon-Hong and coll. highlight an emerging methodology of enatioselective C-C coupling via fluorocarbanion additions, which significantly expands the scope of enantio-enriched fluorine-containing compounds that can be synthesised. The recent advances in the application of organofluoro nucleophiles in organocatalysis are described.
- Read all about this emerging methodology in the Perspective article, FREE to access for the next 4 weeks!
Enantioselective organocatalytic fluorination using organofluoro nucleophiles
Yujun Zhao, Yuanhang Pan, Sui-Boon Derek Sim and Choon-Hong Tan
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C1OB05840A, Perspective
