This Hot Article by Christopher Frost et al. at the University of Bath (UK) describes the utility of novel silyl-protected dioxaborinanes, performing as excellent donors in rhodium-catalysed 1,4-addition reactions under anhydrous conditions. This approach allows the enantioselective addition to arylidene Meldrum’s acid derivatives and a subsequent asymmetric synthesis of 4-arylchroman-2-ones, an important class of bioactive and pharmaceutically-relevant compounds.
Why not read this OBC Communication now! It will be FREE to access for the next four weeks.
Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones
Joseph C. Allen, Gabriele Kociok-Köhn and Christopher G. Frost
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C1OB06586F, Communication