Mario Waser et al. have designed new N-spiro quaternary ammonium salt-based catalysts from tartaric acid-derived TADDOLs. The new catalysts catalyse the asymmetric α-alkylation of glycine Schiff bases in good yields and up to 93% ee.
Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts
Mario Waser, Katharina Gratzer, Richard Herchl and Norbert Müller
DOI: 10.1039/C1OB06573D
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