Using DOSY NMR spectroscopy, collaborators from the Scripps Research Institute in La Jolla (USA) and Pfizer Worldwide Research have systemically measured the self-diffusion rates of linear vs. macrocyclic drug-like structures.
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Comparison of diffusion coefficients for matched pairs of macrocyclic and linear molecules over a drug-like molecular weight range
Andrew R. Bogdan, Nichola L. Davies and Keith James
Org. Biomol. Chem., 2011, 9, 7727-7733
DOI: 10.1039/C1OB05996C
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