Organic & Biomolecular Chemistry Blog

Leo Radom and collaborators in Australia and Switzerland present in this paper a thorough computational study, which correlates with experimental data, of the stability of a very large series of multiply-substituted carbon-centered radicals. They look at the stabilization and interaction energies and the deviations from additivity of RSEs.

The cover image depicts how the stabilities of multiply-substituted carbon-centered radicals are compared with the stabilities of their monosubstituted components. The factors that influence the effect of substituents on such a comparison are discussed.

This article will be included in the OBC special issue in memory of Athel Beckwith: Free Radical Chemistry. Coming soon.

Effect of substituents on the stabilities of multiply-substituted carbon-centered radicals
Ambili S. Menon, David J. Henry, Thomas Bally and Leo Radom
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05196B