Andrew Whiting and colleagues at University of Durham and Merck Research Laboratories, question whether the mechanism of the aza-Diels–Alder reaction is step wise as opposed to concerted when using
oxygenated dienes.
This review explain the mechanistic details as well as scope of the reaction in future.
Mannich–Michael versus formal aza-Diels–Alder approaches to piperidine derivatives
P. Ricardo Girling, Takao Kiyoi and Andrew Whiting
Org. Biomol. Chem., 2011, 9, 3105-3121
DOI: 10.1039/C0OB00996B
