Archive for January, 2011

HOT: Treasures from the Free Radical Renaissance Period

Carl Schiesser takes us through the evolution of Free Radical Chemistry in this very original and well written paper that highlights results from the Beckwith “golden era”.
Join us in this trip from the “Dark Ages” of Free Radical Chemistry to the Post-Renaissance period.  The paper will be free to access until 4th February.

In the paper, they determine the rate constant data and Arrhenius parameters for a series of substituted hexenyl radicals of differing electronic and steric demand.

This paper will be included in the special issue on ‘Free Radical Chemistry’ in memory of Athel Beckwith that will be published in Spring. Keep an eye on it.

Treasures from the Free Radical Renaissance Period – Miscellaneous hexenyl radical kinetic data
Athelstan L. J. Beckwith and Carl H. Schiesser
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00708K, Paper

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HOT: A potential antihypertensive drug

Inhibition of angiotensin converting enzyme (ACE) is generally used as one of the methods for the treatment of hypertension. ‘Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. Hypertension and oxidative stress may be interdependent. Therefore, ACE inhibitors having antioxidant properties are considered beneficial for the treatment of hypertension.

Bhaskar J. Bhuyan and Govindasamy Mugesh at the Indian Institute of Science in Bangalore, India, synthesise in this paper a number of selenium analogues of captopril, an ACE inhibitor used as an antihypertensive drug. These analogues not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.

Read this paper which is free to access until the 4th February. The referees strongly recommended it and the editorial office as well.

Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors Bhaskar J. Bhuyan and Govindasamy Mugesh
 Org. Biomol. Chem
., 2011, Advance Article
DOI: 10.1039/C0OB00823K, Paper

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HOT: Expanding the catalogue of emission colours

Bruce A. Armitage and his team at Carnegie Mellon University in Pittsburgh, USA, create a new family of blue fluoromodules with low nanomolar Kds and high quantum yields.
These fluoromodules provide a new technology for multicolour fluorescent labelling and cellular imaging.

This is a very interesting paper that has been rated as very significant by all the referees.

You don’t want to miss this one! Read it now – it is free to access until the 4th February.

Blue fluorescent dye-protein complexes based on fluorogenic cyanine dyes and single chain antibody fragments
Kimberly J. Zanotti, Gloria L. Silva, Yehuda Creeger, Kelly L. Robertson, Alan S. Waggoner, Peter B. Berget and Bruce A. Armitage
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB00444H

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Unnatural aromatic amino acids – Cover Issue 2

Gangadhar J. Sanjayan and his team at the National Chemical Laboratory in Pune, India, write about the development of conformationally constrained unnatural aromatic amino acids in this communication that is the cover of OBC Issue 2.

The strategy described within the paper will be useful for the construction of oligomers displaying novel molecular architectures with unique conformations, distinct from those classically observed.

Download this paper free to access for a limited period of time.

Congratulations to the authors for a beautiful cover and their interesting research.

Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers
Veera V. E. Ramesh, Arup Roy, Kuruppanthara N. Vijayadas, Amol M. Kendhale, Panchami Prabhakaran, Rajesh Gonnade, Vedavati G. Puranik and Gangadhar J. Sanjayan
Org. Biomol. Chem., 2011, 9, 367-369
DOI: 10.1039/C0OB00593B, Communication

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Meet the OBC team

The OBC team will be attending a number of conferences in 2011 and we would be delighted to meet you.

These are just some of the conferences where you can meet us in the coming months:

Please let us know if you are planning on attending any of these meetings as it would be lovely to meet you there.

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