Véronique Gouverneur and colleagues at University of Oxford, UK, have designed an excellent avenue to generate 18F-labelled molecules via traceless Staudinger ligation.
This OBC HOT article is free to access until the end of the year. The referees rated it as very significant and the authors say that this novel prosthetic group 18F-radiochemistry may find numerous applications in the context of peptide 18F-labelling as the new functionality installed upon ligation is the native amide bond.
This article is part of the fluorine chemistry web themed issue that will be published on line in December. Watch out for it and if you want us to let you know when it is published contact us.
The traceless Staudinger ligation for indirect 18F-radiolabelling
Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore, Jérôme Declerck and Véronique Gouverneur
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00564A , Paper