Carlos Barbas III and Nobuyuki Mase look at recent developments and applications of aldolase-type organocatalytic direct transformations in aqueous media in this new Perspective article. You will learn more about the role of water in organocatalysis, a field that is rapidly developing.
In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water
Nobuyuki Mase, Carlos F. Barbas and III, Org. Biomol. Chem., 2010
On the same theme, take a look at Thomas Nugent and colleagues’ recent paper on diastereo- and enantioselective aqueous aldol reactions and discover a very promising organocatalyst template for this kind of reaction.
Picolylamine as an organocatalyst template for highly diastereo- and enantioselective aqueous aldol reactions
Thomas C. Nugent, M. Naveed Umar and Ahtaram Bibi, Org. Biomol. Chem., 2010