Archive for the ‘Uncategorized’ Category

Ready. Set. GO!

Graphene oxide (GO) is a versatile material with applications ranging from electronics to energy storage and biosensors. As a biosensing substrate, GO has many favorable attributes such as low cost, high signal-to-noise ratio, and the ability to efficiently quench fluorescence.

Scheme for the GO-aptamer based sensor for detection of thrombin.

This ability to quench fluorescence has inspired a range of biosensors using GO and Förster resonance energy transfer (FRET) for the sensitive detection of proteins using labelled probes, such as aptamers. However, the target proteins in such assays can non-specifically adsorb onto the surface of GO, thereby reducing the sensitivity.

To address this, Gao and co-workers implemented the use of polyethylene glycol (PEG) to prevent the non-specific adsorption of thrombin onto GO while implementing an aptamer-binding assay.  The authors report that the detection limit could be improved by optimizing the GO:PEG concentration. This manuscript helps to establish GO as promising tool in the biomedical and biotechnology fields.

Highly sensitive detection for proteins using graphene oxide-aptamer based sensors
Li Gao, Qin Li, Raoqi Li, Lirong Yan, Yang Zhou, Keping Chen and Haixia Shi
Nanoscale, 2015, Advance Article. DOI: 10.1039/C5NR01187F

Dr Lee Barrett is a guest web writer for the Nanoscale blog. Lee is currently a postdoctoral researcher in the Centre for Molecular Nanometrology at the University of Strathclyde. His research is currently focused on the development of nanoparticle-based sensors and surface enhanced Raman scattering (SERS). Follow him on Twitter @L_Bargie.

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In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

An in-situ synthesis of biocompatible fluorescent carbon nanoparticles (FCNs) is reported for targeted bioimaging. The nanoparticles were formed via dehydration of hyalurinic acid (HA), and through careful alteration of the carbonisation times, the total content of HA and fluorescence in the carbon nanoparticles could be controlled. Sharker et al. then compared two colloidally stable FCN samples; one partially carbonised sample that still contained some HA (HA-FCN), against a “non-specific” fully carbonised sample containing no HA (FCN).

Before in vivo testing, both sets of particles were tested on different cell lines at dosages up to 1.0 mg/ml and were found to not affect cell viability. Interestingly, HA-FCNs showed more uptake than the non-specific FCNs, and were internalised more various cell lines; including cancer cells. This is speculated to be due to the over expression of the CD-44 receptor which can facilitate uptake of particles containing targeting molecules such as HA-FCNs. In vivo bio-distribution studies showed more accumulation of HA-FCNs in tumours pre-implanted into mice compared to FCNs, when particles were injected into the tail vein. This is expected to be of enormous potential in not only bioimaging, but also drug delivery and diagnostics.

In situ synthesis of luminescent carbon nanoparticles toward target bioimaging
Shazid Md. Sharker, Sung Min Kim, Jung Eun Lee, Ji Hoon Jeong, Insik In, Kang Dea Lee, Haeshin Lee and Sung Young Park
Nanoscale, 2015, 7, 5468-5475. DOI: 10.1039/C4NR07422J

Dr Mike Barrow is a guest web writer for the Nanoscale blog. He currently works as a Postdoctoral Researcher at the University of Liverpool.

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Nanoscale Issue 4 of 2014 out now!

Graphical abstract: Front coverNanoscale is delighted to present its current issue.

Towards biocompatible nano/microscale machines: self-propelled catalytic nanomotors not exhibiting acute toxicity is the article highlighted on the outside front cover by Elaine Lay Khim Chng, Guanjia Zhao and Martin Pumera.

The inside front cover features an article on Design of advanced porous graphene materials: from graphene nanomesh to 3D architectures by Lili Jiang and Zhuangjun Fan.

Issue 3 contains the following Review, Feature and Mini-review articles:

Highly reactive {001} facets of TiO2-based composites: synthesis, formation mechanism and characterization
Wee-Jun Ong, Lling-Lling Tan, Siang-Piao Chai, Siek-Ting Yong and Abdul Rahman Mohamed Graphical abstract: Inside front cover

Engineering BiOX (X = Cl, Br, I) nanostructures for highly efficient photocatalytic applications
Hefeng Cheng, Baibiao Huang and Ying Dai

Metallic glass nanostructures: fabrication, properties, and applications
Lianci Liu, Molla Hasan and Golden Kumar

Inorganic nanostructured materials for high performance electrochemical supercapacitors
Sheng Liu, Shouheng Sun and Xiao-Zeng You

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This week’s HOT article

Take a look at this week’s selection! This article is available free for a limited time: Graphical abstract: Emerging advances in nanomedicine with engineered gold nanostructures

Emerging advances in nanomedicine with engineered gold nanostructures
Joseph A. Webb and Rizia Bardhan
DOI: 10.1039/C3NR05112A, Review Article

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Nanoscale Issue 3 of 2014 out now!

Graphical abstract: Front coverNanoscale is delighted to present its current issue.

Size-dependent propagation of Au nanoclusters through few-layer graphene is the article highlighted on the outside front cover by Simon R. Plant, Lu Cao, Feng Yin, Zhi Wei Wang and Richard E. Palmer.Graphical abstract: Inside front cover

The inside front cover features an article on Curved polymer nanodiscs by wetting nanopores of anodic aluminum oxide templates with polymer nanospheres by Mu-Huan Chi, Yi-Huei Kao, Tzu-Hui Wei, Chih-Wei Lee and Jiun-Tai Chen.

Issue 3 contains the following Feature article:

Hollow/porous nanostructures derived from nanoscale metal–organic frameworks towards high performance anodes for lithium-ion batteries
Lin Hu and Qianwang Chen

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Nanoscale Issue 2 of 2014 out now!

Graphical abstract: Front coverNanoscale is delighted to present its current issue:

One-step synthesis of carbon nanosheets converted from a polycyclic compound and their direct use as transparent electrodes of ITO-free organic solar cells is the article highlighted on the outside front cover by Su-Young Son, Yong-Jin Noh, Changsuk Bok, Sungho Lee, Byoung Gak Kim, Seok-In Na and Han-Ik Joh.Graphical abstract: Inside front cover

The inside front cover features an article on Synergistic influence of polyoxometalate surface corona towards enhancing the antibacterial performance of tyrosine-capped Ag nanoparticles by Hemant K. Daima, P. R. Selvakannan, Ahmad E. Kandjani, Ravi Shukla, Suresh K. Bhargava and Vipul Bansal.

Issue 2 contains the following Review article:

Nanomedicine: de novo design of nanodrugs
Zaixing Yang, Seung-gu Kang and Ruhong Zhou

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Nanoscale Issue 1 of 2014 out now!

Graphical abstract: Front coverNanoscale is delighted to present its current issue.

Strong localized surface plasmon resonance effects of Ag/TiO 2 core–shell nanowire arrays in UV and visible light for photocatalytic activity is the article highlighted on the outside front cover by Hyeonjin Eom, Joo-Yun Jung, Yosep Shin, Sarah Kim, Jun-Hyuk Choi, Eungsug Lee, Jun-Ho Jeong and Inkyu Park.

The inside front cover features an article on Photocatalysts with internal electric fields by Li Li, Paul A. Salvador and Gregory S. Rohrer.

Issue 1 contains the following Review and Feature articles:

Semicondutor quantum dots-based metal ion probes
Peng Wu, Ting Zhao, Shanling Wang and Xiandeng Hou

Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies
Che-Ming J. Hu, Ronnie H. Fang, Brian T. Luk and Liangfang ZhangGraphical abstract: Inside front cover

Rice- and butterfly-wing effect inspired self-cleaning and low drag micro/nanopatterned surfaces in water, oil, and air flow
Gregory D. Bixler and Bharat Bhushan

Tailoring photocatalytic nanostructures for sustainable hydrogen production
Matteo Cargnello and Benjamin T. Diroll

Polymer-directed synthesis of metal oxide-containing nanomaterials for electrochemical energy storage
Yiyong Mai, Fan Zhang and Xinliang Feng

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Nanoscale Issue 24 of 2013 out now!

Nanoscale is delighted to present its current issue.

Biophotonic logic devices based on quantum dots and temporally-staggered Förster energy transfer relays is the article highlighted on the outside front cover by Jonathan C. Claussen, W. Russ Algar, Niko Hildebrandt, Kimihiro Susumu, Mario G. Ancona and Igor L. Medintz.

The inside front cover features an article on Quantum dot approaches for target-based drug screening and multiplexed active biosensing by Oleg Kovtun, Xochitl Arzeta-Ferrer and Sandra J. Rosenthal.

Issue 24 contains the following Review and Feature articles:

Electrohydrodynamic direct-writing
YongAn Huang, Ningbin Bu, Yongqing Duan, Yanqiao Pan, Huimin Liu, Zhouping Yin and Youlun Xiong

Polymer-coated quantum dots
Nikodem Tomczak, Rongrong Liu and Julius G. Vancso

Applications of nanomaterials in mass spectrometry analysis
Chang Lei, Kun Qian, Owen Noonan, Amanda Nouwens and Chengzhong Yu

Localized surface plasmon resonance: a unique property of plasmonic nanoparticles for nucleic acid detection
Kah Ee Fong and Lin-Yue Lanry Yung

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This week’s HOT articles

Take a look at this week’s selection! These articles are available free for a limited time:

Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics
Yang Liu, Zheng Chang, Hsiangkuo Yuan, Andrew M. Fales and Tuan Vo-DinhBipolar switching polarity reversal by electrolyte layer sequence in electrochemical metallization cells with dual-layer solid electrolytes
DOI: 10.1039/C3NR03762B, Communication

Bipolar switching polarity reversal by electrolyte layer sequence in electrochemical metallization cells with dual-layer solid electrolytes
Rohit Soni, Paul Meuffels, Adrian Petraru, Mirko Hansen, Martin Ziegler, Ondrej Vavra, Hermann Kohlstedt and Doo Seok Jeong
DOI: 10.1039/C3NR03993E, Paper

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Nanoscale Issue 22 of 2013 out now!

Nanoscale Issue 22 Outside Front CoverNanoscale is delighted to present its current issue.

Electron beam induced local crystallization of HfO 2 nanopores for biosensing applications is the article highlighted on the outside front cover by Jiwook Shim, Jose A. Rivera and Rashid Bashir.

The inside front cover features an article on Single Particle Orientation and Rotational Tracking (SPORT) in biophysical studies by Yan Gu, Ji Won Ha, Ashley E. Augspurger, Kuangcai Chen, Shaobin Zhu and Ning Fang.

Issue 21 contains the following Review, Feature, and Opinion articles:

Nanostructure-based optoelectronic sensing of vapor phase explosives – a promising but challenging method
Baiyi Zu, Yanan Guo and Xincun Dou, Nanoscale

Current and emerging challenges of field effect transistor based bio-sensing Nanoscale Issue 22 Inside Front Cover
Akira Matsumoto and Yuji Miyahara, Nanoscale

Intravenous hemostats: challenges in translation to patients
Margaret Lashof-Sullivan, Andrew Shoffstall and Erin Lavik, Nanoscale

Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles
Kostiantyn Turcheniuk, Arkadii V. Tarasevych, Valeriy P. Kukhar, Rabah Boukherroub and Sabine Szunerits, Nanoscale

Synthesis of graphene-supported noble metal hybrid nanostructures and their applications as advanced electrocatalysts for fuel cells
Chengzhou Zhu and Shaojun Dong, Nanoscale

Single cycle and transient force measurements in dynamic atomic force microscopy
Karim Gadelrab, Sergio Santos, Josep Font and Matteo Chiesa, Nanoscale

Hot spots in different metal nanostructures for plasmon-enhanced Raman spectroscopy
Hong Wei and Hongxing Xu, Nanoscale

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