Issue 2s, home to the much awaited Marine Natural Products review by John Blunt et al., and much more.
Featuring on the front cover is the work of Jorge A. R. Salvador, M. Luisa Sá e Melo and colleagues at University of Coimbra and Universidade da Beira Interior (Portugal), illustrating their review detailing the anticancer activity of steroids.
In this issue:
Hot off the press
Robert A. Hill and Andrew Sutherland
A personal selection of 33 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as breitfussin A from the Arctic hydrozoan Thuiaria breitfussi.
Biosynthesis of thiopeptide antibiotics and their pathway engineering
Qi Zhang and Wen Liu
A Highlight including advances during 2009–2012 in understanding the generality and specificity of thiopeptide biosynthesis, and on this basis, in expanding the structural diversity by pathway engineering.
α-Haloaldehydes: versatile building blocks for natural product synthesis
Robert Britton and Baldip Kang
This Highlight summarizes the organocatalytic processes available for the enantioselective preparation of α-haloaldehydes and their stereoselective conversion into natural products.
Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
The much awaited Marine Natural Products review article! Included is an example of the development of genome mining for the discovery of new compounds from marine microbes leading to the finding of salinosporamide K from Salinispora pacifica.
Missed the previous ones? Catch up with the past 5 years of this series:
Marine Natural Products – 2012
Marine Natural Products – 2011
Marine Natural Products – 2010
Marine Natural Products – 2009
Marine Natural Products – 2008
Anticancer steroids: linking natural and semi-synthetic compounds
Jorge A. R. Salvador, João F. S. Carvalho, Marco A. C. Neves, Samuel M. Silvestre, Alcino J. Leitão, M. Manuel C. Silva and M. Luisa Sá e Melo
Steroids, a widespread class of natural compounds, have shown great therapeutic value for a broad array of pathologies. This overview is focused on their anticancer activity, which is very representative of a rich structural diversity and ability to interact with various biological targets and pathways.
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