Natural Product Reports recently published two Highlight articles looking at Heparin, in contrasting but complementary approaches.
We thought you would like to have them side-by-side!
Pierre-Alexandre Driguez et al. present the total synthesis of Idra(biota)parinux, a fully synthetic analog of heparin, that has been designed and synthesized at Sanofi. Their Highlight also looks at chemical optimization performed in order to acheive the scale-up of batches, mandatory for clinical development. Jian Liu and Robert Linhardt’s article focuses on heparin syntheses that rely principally on enzymatic methods.
We hope you enjoy these articles. Let us kow what you think by leaving a comment below. Also, do keep an eye for a small web collection of articles on Carbohydrates, coming soon…
Synthetic oligosaccharides as active pharmaceutical ingredients: Lessons learned from the full synthesis of one heparin derivative on a large scale
Pierre-Alexandre Driguez, Pierre Potier and Patrick Trouilleux
Nat. Prod. Rep., 2014, 31, 980-989
DOI: 10.1039/C4NP00012A, Highlight
Chemoenzymatic synthesis of heparan sulfate and heparin
Jian Liu and Robert J. Linhardt
Nat. Prod. Rep., 2014,31, 1676-1685
DOI: 10.1039/C4NP00076E, Highlight