Archive for the ‘News’ Category

7800 new natural product compounds in ChemSpider

Do you know about Natural Product Updates?

Natural Product Updates (NPU) gives you the molecules involved in key developments in natural product chemistry. Thanks to our work in interpreting what chemists mean, not just what chemists draw, ChemSpider now links to NPU’s data for 13800 natural products since 2005, of which 7800 are brand new to ChemSpider.

Where ChemSpider has information on a compound in NPU you will see the image above, as in, for example, calothrixin B. This is a link to NPU page on the RSC Publishing Platform.

Soon we’ll be integrating more of our graphical databases into ChemSpider. Watch this space!

Want to know more about ChemSpider?

Read all about the free chemical structure database providing fast search access to over 26 million structures from hundreds of data sources, and follow the latest news and development on the ChemSpider blog.

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Sucrose analogues for glycodiversification on the cover of NPR issue 9

Welcome to Natural Product Reports Issue 9, 2012


NPR’s cover this month features artwork by Isabelle Andre et al. that illustrates their review article covering the main biological routes to sucrose derivatives or analogs that are prevalent in nature. The review also higlights the potential applications of sucrose derivatives in sugar bioconversion, in particular through the engineering of substrates, enzymes or microorganisms.

Sucrose analogs: an attractive (bio)source for glycodiversification
David Daudé, Magali Remaud-Siméon and Isabelle André
DOI: 10.1039/C2NP20054F

Enjoy FREE access to this article for the next 6 weeks upon a simple registration process.

Also in this September issue, we trust you will find the following reviews intersting and stimulating to read. Let us know what you think by leaving a comment below!

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On the cover this month: The Cephalotaxus genus: a source of alkaloids and terpenoids

Welcome to Natural Product Reports Issue 8, 2012

Featuring on this month’s cover is work by Hajer Abdelkafi and Bastien Nay at the Museum National d’Histoire Naturelle (CNRS-MNHN, Paris, France) on natural products from the Cephalotaxus sp., which belongs to the Cephalotaxaceae family of conifers.

This genus has showed to provide both interesting alkaloids with anticancer potential, and original norditerpene tropones with cytotoxic activity. In this review article the authors present a phytochemical update and discuss the total synthesis of alkaloids and terpenoids in detail.

Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects
Hajer Abdelkafi and Bastien Nay
DOI: 10.1039/C2NP20037F

Why not also read in this issue:

Robert A. Hill and Andrew Sutherland’s Hot off the Press showcasing a personal selection of 32 recent papers covering current developments in bioorganic chemistry and novel natural products such as lycojaponicumin A from Lycopodium japonicum:

 

 

 

 

 

Like what you read? If you would like to contribute an article to NPR, please contact the editorial office with a proposed topic and we will be pleased to evaluate your synopsis.

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2011 Impact Factor for OBC, MedChemComm & NPR

The 2011 Journal Citation Reports ® (Thomson Reuters, 2012) have just been released, which showed:

Organic & Biomolecular Chemistry: 3.696

MedChemComm: 2.8         (Partial IF only, based on five issues)

Natural Product Reports: 9.79

The Cambridge Editorial Office would like to thank everyone involved for their hard work and dedication to all three journals over the years. In particular, we would like to thank all of our Associate Editors, Editorial and Advisory Board members, authors and referees, without whom none of this would have been possible.

With another successful year in the bag, we hope you will join us in making this year even better…

Read more about the 2011 Impact Factors from across RSC Publishing on the RSC Publishing Blog.

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Rare glycosylation of peptides and proteins on the cover of this month’s issue of NPR

Welcome to NPR issue 7, 2012


Richard Daniellou and Pierre Lafite (ICOA, Orleans, France) have designed this issue’s cover, illustrating their review article on rare and unusual glycosylation of peptides and proteins.
Glycosylation represents the most complex co- and post-translational modification of proteins, and the article focuses on the source and nature of rare glycosidic linkages, rare carbohydrates, and the mechanism of glycosyltransferases, providing the reader with a complete overview of this very relevant topic.

Rare and unusual glycosylation of peptides and proteins
Pierre Lafite and Richard Daniellou
DOI: 10.1039/C2NP20030A

Also in this issue, we trust you will enjoy:

The isoprenoid-precursor dependence of Plasmodium spp.
Jan-Ytzen van der Meer and Anna K. H. Hirsch
Nat. Prod. Rep., 2012, 29, 721-728

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products
Mélanie Roué, Elodie Quévrain, Isabelle Domart-Coulon and Marie-Lise Bourguet-Kondracki
Nat. Prod. Rep., 2012, 29, 739-751

Synthetic approaches toward sesterterpenoids
Daniel T. Hog, Robert Webster and Dirk Trauner
Nat. Prod. Rep., 2012, 29, 752-779

Authored by NPR Board Member Dirk Trauner and members of his team, why not view Dirk’s profile on our blog… Read.

Also containing the all time favourite:

Triterpenoids
Robert A. Hill and Joseph D. Connolly
Nat. Prod. Rep., 2012, 29, 780-818

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The fungal Pestalotiopsis genus on the cover of NPR issue 6

NPR issue 6, 2012, is here!

The cover of this month’s NPR features a review by Du-Qiang Luo et al. which discusses the taxonomy, biology and chemistry of the Pestalotiopsis genus as well as covering biosynthetic relationships and synthesis of metabolites of this genus. Take a look, it will be free to access for 6 weeks!

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
DOI: 10.1039/C2NP00073C

Also in the issue; read the latest Hot Off The Press article by Robert A. Hill and Andrew Sutherland, as well as these reviews:

Pheromones, attractants and other chemical cues of aquatic organisms and amphibians
Scott F. Cummins and John H. Bowie
DOI: 10.1039/C2NP00102K

Electrophilic natural products and their biological targets
Malte Gersch, Johannes Kreuzer and Stephan A. Sieber
DOI: 10.1039/C2NP20012K

The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
Jennifer Guerra-Bubb, Rodney Croteau and Robert M. Williams
DOI: 10.1039/C2NP20021J

Glycosynthases as tools for the production of glycan analogs of natural products
Beatrice Cobucci-Ponzano and Marco Moracci
DOI: 10.1039/C2NP20032E

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RSC US Roadshow 2012 – Week 4: North East

Natural Product Reports Editor Richard Kelly will be visiting several North East universities next week as part of the RSC US Roadshows 2012.

Week 4 sees the Royal Society of Chemistry visiting four universities in Pennsylvania and New York:

May 7th – University of Pittsburgh
May 8th – Pennsylvania State University
May 10th – University of Pennsylvania
May 11th – Columbia University

Read more about the US roadshows 2012:

Starting in mid April 2012, RSC Publishing has been touring the United States of America to share more than 170 years experience of publishing in the chemical sciences. Sixteen universities across the country are hosting these one-day events, which are open to all members of the hosting institute.

Attendees have the opportunity to explore RSC’s apps on mobile devices and meet informally with RSC editors. Lunchtime discussion groups explore reading habits and opportunities in the 21st century and an afternoon seminar give an insight into the world of scholarly publishing, with tips on how to get published in high impact journals. A demonstration of ChemSpider, and a guest lecture from an RSC associate editor or board member are available at many of the roadshows.

Follow the RSC Roadshows on Twitter – just look for #RSC2012.

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Cytotoxic and antioxidant marine natural products on the cover of NPR issue 5

Welcome to NPR issue 5, 2012

This month’s striking subaquatic cover features the work of Suthananda N. Sunassee and Michael T. Davies-Coleman at Rhodes University, Grahamstown, South Africa,  with a review on Cytotoxic and antioxidant marine prenylated quinones and hydroquinones.
Focusing on 159 prenylated quinones, hydroquinones and naphthoquinones with reported cytotoxic and/or antioxidant properties isolated from various marine organisms over the past 40 years, the authors highlight trends in the structural distribution of these cytotoxic compounds within the different marine phyla.

Cytotoxic and antioxidant marine prenylated quinones and hydroquinones
Suthananda N. Sunassee and Michael T. Davies-Coleman
Nat. Prod. Rep., 2012, 29, 513-535
DOI: 10.1039/C2NP00086E

Also in this May issue, why not read:

NMR in natural products: understanding conformation, configuration and receptor interactions
Teresa Carlomagno
Nat. Prod. Rep., 2012, 29, 536-554

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Edwin G. Pérez, Carolina Méndez-Gálvez and Bruce K. Cassels
Nat. Prod. Rep., 2012, 29, 555-567

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation
Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara and Koichi Fukase
Nat. Prod. Rep., 2012, 29, 568-579

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606

Access the full issue

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There is still time to join ICPOC21!

Good news!

There’s still a chance to submit your oral abstract to ICPOC21: 21st IUPAC International Conference on Physical Organic Chemistry organised by the Organic Division of the RSC on behalf of IUPAC, to be held 9 – 13 September 2012 at Durham University.

The Scientific Committee is currently reviewing all submissions, and has agreed to accept contributions up to Friday 13 April to allow for the Easter holiday break.

Why join ICPOC21?

 
Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

Make sure you are one of them! Don’t miss the oral abstract submission deadline – 13 April.

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Vibsane-type diterpenoids on the cover of NPR issue 4

Welcome to NPR issue 4, 2012!

This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.

Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A

Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,

A Highlight by Jiyong Hong and Hendrik Luesch  on Largazole,  a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product: 

A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:

Richard Robins and Guillaume Tcherkez et al. ’s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:

R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:

View the issue

 

Also of Interest:
The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble

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