Archive for the ‘News’ Category

2013 NPR Lectureship award – nominations now open!

We are delighted to announce that the 2013 NPR Lectureship award nominations are now open.

The NPR Lectureship is an annual event which is held at an international meeting. From 2013 the NPR Lectureship will be awarded to an Emerging Investigator, with the recipient being a researcher who has made a significant contribution to any natural products-related in their early independent career. Nominees should have completed their PhD on or after the 31st December 2000.

To nominate, please send the name of the person along with a brief justification to NPR Editor, Richard Kelly. Nominations are open to everyone and should be received by 31st December 2012.

The winner will be selected by a panel of judges and the result will be annouced in early 2013. The 2012 winner was Dean Tantillo, UC Davis Chemistry, USA whose research contributed significantly to the understanding of mechanistic enzymology.

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Natural Product Updates: now structure-searchable in ChemSpider

Natural Product Updates

Natural Product Updates (NPU) provides graphical abstracts of new developments in natural product chemistry, selected from dozens of key primary journals. Coverage includes:

  • Isolation studies
  • Biosynthesis
  • New natural products
  • Known compounds from new sources
  • Structure determinations
  • New properties and biological activities     

Around 200 graphical abstracts are contained in each monthly bulletin, including structure diagrams, trivial and taxonomic names, molecular formulae, physical and biological properties

Browse this Database

Subscribers to the monthly print bulletin also have free access to Natural Product Updates Online – the fully searchable web database which allows users to search across all items published in Natural Product Updates to date. This service provides full text search capability on a variety of terms.

An email alerting service is also available, allowing users to sign up for an email message every time a new monthly bulletin is published online.

Natural Product Updates, is now structure searchable in ChemSpider

Want to know more about ChemSpider?

Read all about the free chemical structure database providing fast search access to over 26 million structures from hundreds of data sources, and follow the latest news and development on the ChemSpider blog.

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Plant defense mechanisms on the cover of NPR Issue 11

Welcome to Natural Product Reports Issue 11, 2012

The cover this month illustrates work by Massimo E. Maffei (University of Turin) et al. presenting the diversity of plants defense mechanisms that are activated when plants are under attack from potentially dangerous microbes and insect herbivores, and plant-plant interactions. Enjoy FREE access to this article for the next 6 weeks upon a simple registration process:

Natural elicitors, effectors and modulators of plant responses
Massimo E. Maffei, Gen-Ichiro Arimura and Axel Mithöfer
DOI: 10.1039/C2NP20053H

Also in this issue, read:

Bioactive natural products from Lysobacter
Yunxuan Xie, Stephen Wright, Yuemao Shen and Liangcheng Du
DOI: 10.1039/C2NP20064C

Natural product ‘legal highs’
Warunya Arunotayanun and Simon Gibbons
DOI: 10.1039/C2NP20068F

Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae
Céline Rivière, Alison D. Pawlus and Jean-Michel Mérillon
DOI: 10.1039/C2NP20049J

Natural sesquiterpenoids
Braulio M. Fraga
DOI: 10.1039/C2NP20074K

Guest edited by Professor Christopher Walsh and Dr Sylvie Garneau-Tsdodikova, the issue contains some of the newest discoveries in the field, along with 9 review articles that will lead the reader through exciting natural products research. Let us know what you think!

         

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Top ten most accessed articles in July 2012

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

The generation of “unNatural” products: Synthetic biology meets synthetic chemistry  
Rebecca J. M. Goss, Sreejith Shankar and Antoine Abou Fayad  
Nat. Prod. Rep., 2012, 29, 870-889
DOI: 10.1039/C2NP00001F

Hot off the Press 
Robert A. Hill and Andrew Sutherland  
Nat. Prod. Rep., 2012, 29, 829-833
DOI: 10.1039/C2NP90024F 

Strained cyclophane natural products: Macrocyclization at its limits 
Tanja Gulder and Phil S. Baran  
Nat. Prod. Rep., 2012, 29, 899-934
DOI: 10.1039/C2NP20034A

Plants as sources of new antimicrobials and resistance-modifying agents  
Ana Cristina Abreu, Andrew J. McBain and Manuel Simões  
Nat. Prod. Rep., 2012, 29, 1007-1021
DOI: 10.1039/C2NP20035J

Marine natural products  
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep  
Nat. Prod. Rep., 2012, 29, 144-222
DOI: 10.1039/C2NP00090C 

Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects  
Hajer Abdelkafi and Bastien Nay  
Nat. Prod. Rep., 2012, 29, 845-869
DOI: 10.1039/C2NP20037F 

Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products  
R. Adam Mosey and Paul E. Floreancig  
Nat. Prod. Rep., 2012, 29, 980-995
DOI: 10.1039/C2NP20052J 

Diterpenoids of terrestrial origin  
James R. Hanson  
Nat. Prod. Rep., 2012, 29, 890-898
DOI: 10.1039/C2NP20051A 

The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways  
Pascal Belin, Mireille Moutiez, Sylvie Lautru, Jérôme Seguin, Jean-Luc Pernodet and Muriel Gondry
Nat. Prod. Rep., 2012, 29, 961-979
DOI: 10.1039/C2NP20010D 

Diversity of P450 enzymes in the biosynthesis of natural products  
Larissa M. Podust and David H. Sherman  
Nat. Prod. Rep., 2012, 29, 1251-1266
DOI: 10.1039/C2NP20020A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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7800 new natural product compounds in ChemSpider

Do you know about Natural Product Updates?

Natural Product Updates (NPU) gives you the molecules involved in key developments in natural product chemistry. Thanks to our work in interpreting what chemists mean, not just what chemists draw, ChemSpider now links to NPU’s data for 13800 natural products since 2005, of which 7800 are brand new to ChemSpider.

Where ChemSpider has information on a compound in NPU you will see the image above, as in, for example, calothrixin B. This is a link to NPU page on the RSC Publishing Platform.

Soon we’ll be integrating more of our graphical databases into ChemSpider. Watch this space!

Want to know more about ChemSpider?

Read all about the free chemical structure database providing fast search access to over 26 million structures from hundreds of data sources, and follow the latest news and development on the ChemSpider blog.

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Sucrose analogues for glycodiversification on the cover of NPR issue 9

Welcome to Natural Product Reports Issue 9, 2012


NPR’s cover this month features artwork by Isabelle Andre et al. that illustrates their review article covering the main biological routes to sucrose derivatives or analogs that are prevalent in nature. The review also higlights the potential applications of sucrose derivatives in sugar bioconversion, in particular through the engineering of substrates, enzymes or microorganisms.

Sucrose analogs: an attractive (bio)source for glycodiversification
David Daudé, Magali Remaud-Siméon and Isabelle André
DOI: 10.1039/C2NP20054F

Enjoy FREE access to this article for the next 6 weeks upon a simple registration process.

Also in this September issue, we trust you will find the following reviews intersting and stimulating to read. Let us know what you think by leaving a comment below!

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On the cover this month: The Cephalotaxus genus: a source of alkaloids and terpenoids

Welcome to Natural Product Reports Issue 8, 2012

Featuring on this month’s cover is work by Hajer Abdelkafi and Bastien Nay at the Museum National d’Histoire Naturelle (CNRS-MNHN, Paris, France) on natural products from the Cephalotaxus sp., which belongs to the Cephalotaxaceae family of conifers.

This genus has showed to provide both interesting alkaloids with anticancer potential, and original norditerpene tropones with cytotoxic activity. In this review article the authors present a phytochemical update and discuss the total synthesis of alkaloids and terpenoids in detail.

Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects
Hajer Abdelkafi and Bastien Nay
DOI: 10.1039/C2NP20037F

Why not also read in this issue:

Robert A. Hill and Andrew Sutherland’s Hot off the Press showcasing a personal selection of 32 recent papers covering current developments in bioorganic chemistry and novel natural products such as lycojaponicumin A from Lycopodium japonicum:

 

 

 

 

 

Like what you read? If you would like to contribute an article to NPR, please contact the editorial office with a proposed topic and we will be pleased to evaluate your synopsis.

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2011 Impact Factor for OBC, MedChemComm & NPR

The 2011 Journal Citation Reports ® (Thomson Reuters, 2012) have just been released, which showed:

Organic & Biomolecular Chemistry: 3.696

MedChemComm: 2.8         (Partial IF only, based on five issues)

Natural Product Reports: 9.79

The Cambridge Editorial Office would like to thank everyone involved for their hard work and dedication to all three journals over the years. In particular, we would like to thank all of our Associate Editors, Editorial and Advisory Board members, authors and referees, without whom none of this would have been possible.

With another successful year in the bag, we hope you will join us in making this year even better…

Read more about the 2011 Impact Factors from across RSC Publishing on the RSC Publishing Blog.

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Rare glycosylation of peptides and proteins on the cover of this month’s issue of NPR

Welcome to NPR issue 7, 2012


Richard Daniellou and Pierre Lafite (ICOA, Orleans, France) have designed this issue’s cover, illustrating their review article on rare and unusual glycosylation of peptides and proteins.
Glycosylation represents the most complex co- and post-translational modification of proteins, and the article focuses on the source and nature of rare glycosidic linkages, rare carbohydrates, and the mechanism of glycosyltransferases, providing the reader with a complete overview of this very relevant topic.

Rare and unusual glycosylation of peptides and proteins
Pierre Lafite and Richard Daniellou
DOI: 10.1039/C2NP20030A

Also in this issue, we trust you will enjoy:

The isoprenoid-precursor dependence of Plasmodium spp.
Jan-Ytzen van der Meer and Anna K. H. Hirsch
Nat. Prod. Rep., 2012, 29, 721-728

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products
Mélanie Roué, Elodie Quévrain, Isabelle Domart-Coulon and Marie-Lise Bourguet-Kondracki
Nat. Prod. Rep., 2012, 29, 739-751

Synthetic approaches toward sesterterpenoids
Daniel T. Hog, Robert Webster and Dirk Trauner
Nat. Prod. Rep., 2012, 29, 752-779

Authored by NPR Board Member Dirk Trauner and members of his team, why not view Dirk’s profile on our blog… Read.

Also containing the all time favourite:

Triterpenoids
Robert A. Hill and Joseph D. Connolly
Nat. Prod. Rep., 2012, 29, 780-818

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The fungal Pestalotiopsis genus on the cover of NPR issue 6

NPR issue 6, 2012, is here!

The cover of this month’s NPR features a review by Du-Qiang Luo et al. which discusses the taxonomy, biology and chemistry of the Pestalotiopsis genus as well as covering biosynthetic relationships and synthesis of metabolites of this genus. Take a look, it will be free to access for 6 weeks!

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
DOI: 10.1039/C2NP00073C

Also in the issue; read the latest Hot Off The Press article by Robert A. Hill and Andrew Sutherland, as well as these reviews:

Pheromones, attractants and other chemical cues of aquatic organisms and amphibians
Scott F. Cummins and John H. Bowie
DOI: 10.1039/C2NP00102K

Electrophilic natural products and their biological targets
Malte Gersch, Johannes Kreuzer and Stephan A. Sieber
DOI: 10.1039/C2NP20012K

The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
Jennifer Guerra-Bubb, Rodney Croteau and Robert M. Williams
DOI: 10.1039/C2NP20021J

Glycosynthases as tools for the production of glycan analogs of natural products
Beatrice Cobucci-Ponzano and Marco Moracci
DOI: 10.1039/C2NP20032E

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