Archive for August, 2012

7800 new natural product compounds in ChemSpider

Do you know about Natural Product Updates?

Natural Product Updates (NPU) gives you the molecules involved in key developments in natural product chemistry. Thanks to our work in interpreting what chemists mean, not just what chemists draw, ChemSpider now links to NPU’s data for 13800 natural products since 2005, of which 7800 are brand new to ChemSpider.

Where ChemSpider has information on a compound in NPU you will see the image above, as in, for example, calothrixin B. This is a link to NPU page on the RSC Publishing Platform.

Soon we’ll be integrating more of our graphical databases into ChemSpider. Watch this space!

Want to know more about ChemSpider?

Read all about the free chemical structure database providing fast search access to over 26 million structures from hundreds of data sources, and follow the latest news and development on the ChemSpider blog.

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Directing Bioysynthesis III – deadline approaching

It’s your last chance to register for Directing Biosynthesis III – by the deadline date of Friday 31 August.  

Natural products continue to underpin the developments of new medicines and agrochemicals. Their biosynthesis and role in the environment are increasingly well understood at ecological, chemical, biochemical, and genetic levels and their discovery and exploitation remain key objectives of academics and companies. Significant opportunities exist for engineering biosynthetic pathways in bacteria, fungi and plants for the directed biosynthesis of new natural products with new and beneficial properties. 

We are delighted to announce that a special symposium will take place within the Directing Biosynthesis III programme, recognising the achievements of three RSC award winners of 2011. Each of the winners will give a keynote lecture within the symposium:

  • Professor Jim Naismith, University of St Andrews, UK
    Member of Collaborative Computational Project 4 – STFC Rutherford Appleton Laboratory (CCP4)
    Winners of the Rita and John Cornforth Award 2011

 

  •  Professor Chris Schofield, University of Oxford, UK
    Winner of the Jeremy Knowles Award 2011 

 

  • Dr David R Spring, University of Cambridge, UK
    Winner of the Norman Heatley Award 2011

 

So join them to be a part of  this highly topical conference featuring contributions from the most active groups in the UK, Europe, the USA and Japan working in the rapidly developing area of directed biosynthesis of new natural products.

 

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Natural Products in OBC: our latest selection

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

  • The latest natural products’ related articles have been collated here:

Enantioselective approach to functionalized quinolizidines: synthesis of (+)-julandine and (+)-cryptople urine
Sunil V. Pansare and Rajendar Dyapa

Diverted organic synthesis (DOS): accessing a new, natural product inspired, neurotrophically active scaffold through an intramolecular Pauson–Khand reaction
Goverdhan Mehta, Ramesh Samineni, Pabbaraja Srihari, R. Gajendra Reddy and Sumana Chakravarty

First total synthesis of dioxepine bastadin 3
Santiago Pérez-Rodríguez, Raquel Pereira-Cameselle and Ángel R. de Lera

Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(−)-CCG-II
Pradeep Kumar, Abhishek Dubey and Anand Harbindu

An approach to aliphatic 1,8-stereocontrol: diastereoselective syntheses of (±)-patulolide C and (±)-epipatulolide
C E. Kate Hoegenauer and Eric J. Thomas

Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin
Monique P. C. Mulder, Peter Fodran, Johan Kemmink, Eefjan J. Breukink, John A. W. Kruijtzer, Adriaan J. Minnaard and Rob M. J. Liskamp

Concerted, highly asynchronous, enzyme-catalyzed [4 + 2] cycloaddition in the biosynthesis of spinosyn A; computational evidence
B. Andes Hess and Lidia Smentek

Diastereoselective construction of syn-α-oxyamines via three-component α-oxyaldehyde–dibenzylamine–alkyne coupling reaction: application in the synthesis of (+)-β-conhydrine and its analogues
Sharad Chandrakant Deshmukh, Arundhati Roy and Pinaki Talukdar

Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis
Raúl E. Juárez-Hernández, Scott G. Franzblau and Marvin J. Miller

Guest edited by Professor Christopher Walsh and Dr Sylvie Garneau-Tsdodikova, the issue contains some of the newest discoveries in the field, along with 9 review articles that will lead the reader through exciting natural products research. Let us know what you think!

         

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Sucrose analogues for glycodiversification on the cover of NPR issue 9

Welcome to Natural Product Reports Issue 9, 2012


NPR‘s cover this month features artwork by Isabelle Andre et al. that illustrates their review article covering the main biological routes to sucrose derivatives or analogs that are prevalent in nature. The review also higlights the potential applications of sucrose derivatives in sugar bioconversion, in particular through the engineering of substrates, enzymes or microorganisms.

Sucrose analogs: an attractive (bio)source for glycodiversification
David Daudé, Magali Remaud-Siméon and Isabelle André
DOI: 10.1039/C2NP20054F

Enjoy FREE access to this article for the next 6 weeks upon a simple registration process.

Also in this September issue, we trust you will find the following reviews intersting and stimulating to read. Let us know what you think by leaving a comment below!

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