Welcome to NPR issue 4, 2012!
This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.
Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A
Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,
A Highlight by Jiyong Hong and Hendrik Luesch on Largazole, a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product:
- Largazole: From discovery to broad-spectrum therapy
Jiyong Hong and Hendrik Luesch
Nat. Prod. Rep., 2012, 29, 449-456
DOI: 10.1039/C2NP00066K
A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:
- Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
Zhao-Li Zhou, Ya-Xi Yang, Jian Ding, Yuan-Chao Li and Ze-Hong Miao
Richard Robins and Guillaume Tcherkez et al. ‘s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:
- Biochemical and physiological determinants of intramolecular isotope patterns in sucrose from C3, C4 and CAM plants accessed by isotopic 13C NMR spectrometry: a viewpoint
Alexis Gilbert, Virginie Silvestre, Richard J. Robins, Gérald S. Remaud and Guillaume Tcherkez
R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:
- Phenazines and cancer
A. Cimmino, A. Evidente, V. Mathieu, A. Andolfi, F. Lefranc, A. Kornienko and R. Kiss
| Also of Interest: The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble |
