The latest issue of NPR, featuring five Reviews, is now available online.
Featured in this issue is a Hot Article by Mikhail Elyashberg, Antony Williams and Kirill Blinov. Computer-Assisted Structure Elucidation (CASE) systems have been under development for decades, and in the last ten years that this approach had developed sufficiently to be capable of elucidating the structures of new and complex organic molecules, using a collection of mass spectrometric and NMR data. In this review the authors show how a particular CASE system could be used to accurately determine the structures of a number of complex molecules using 2D NMR data. To illustrate this, they show how the original miss-assignment of the structures of a number of natural products, including cephalandole A, halipeptin A and palominol, could have been avoided using a CASE approach.
