World Alzheimer’s Month 2016

World Alzheimer’s Month September 2016 marks the fifth global World Alzheimer’s Month- an international campaign to raise awareness and challenge stigma.

In support of this event, we have compiled a new online collection bringing together Alzheimer’s and Dementia research published in Metallomics, Analyst, Analytical Methods, Food & Function and Toxiology Research since the beginning of 2015.

Check out the collection here, which will be free to access for one week from Monday September 19 to include the official World Alzheimer’s Day, September 21 2016.

The theme for World Alzheimer’s Month 2016 is Remember Me. You can get involved by sharing your favourite memories, or memories of a loved one, on social media this September with the hashtags #RememberMe #WAM2016.

You can find out more about World Alzheimer’s Month 2016 here.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Check out the newly updated Metals in Marine Biochemistry online collection

The Metals in Marine Biochemistry online collection has now been expanded to include additional reports in this field and to highlight emerging high-impact areas of research on metals in marine biochemistry.

The collection will become a resource for researchers in the field and new articles will be added to this collection as they are published in Metallomics.

Read the collection here.

Do you work in this area? Then why not submit to Metallomics today!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Themed issue highlighting the work presented at the 5th International Conference on Metallomics now published

The new themed issue for Metallomics highlighting work from the 5th International Conference on Metallomics, September 9 – 12, 2015, Beijing, China and Guest Edited by  Professors Chunying Chen, Xingrong Zhang and Zhifang Chai is now published.

We hope you enjoy the issue!

Why not submit your high impact research to Metallomics today. Information about the scope of the Journal can be found here.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Top 10 most accessed Metallomics articles from April – June 2016

From April – June 2016, our most downloaded Metallomics articles were:

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells
Douglas B. Kell and Etheresia Pretorius
Metallomics, 2014,6, 748-773
DOI: 10.1039/C3MT00347G, Perspective

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
Ekaterina Schreiber-Brynzak, Verena Pichler, Petra Heffeter, Buck Hanson, Sarah Theiner, Irene Lichtscheidl-Schultz, Christoph Kornauth, Luca Bamonti, Vineet Dhery, Diana Groza, David Berry, Walter Berger, Markus Galanski, Michael A. Jakupec and Bernhard K. Keppler
Metallomics, 2016,8, 422-433
DOI: 10.1039/C5MT00312A, Paper

Therapeutic and analytical applications of arsenic binding to proteins
Beibei Chen, Qingqing Liu, Aleksandra Popowich, Shengwen Shen, Xiaowen Yan, Qi Zhang, Xing-Fang Li, Michael Weinfeld, William R. Cullen and X. Chris Le
Metallomics, 2015,7, 39-55
DOI: 10.1039/C4MT00222A, Critical Review

Nickel-responsive regulation of two novel Helicobacter pylori NikR-targeted genes
M. D. Jones, I. Ademi, X. Yin, Y. Gong and D. B. Zamble
Metallomics, 2015,7, 662-673
DOI: 10.1039/C4MT00210E, Paper

The role of vanadium in biology
Dieter Rehder
Metallomics, 2015,7, 730-742
DOI: 10.1039/C4MT00304G, Critical Review

Selenium, selenoproteins and neurodegenerative diseases
Bárbara Rita Cardoso, Blaine R. Roberts, Ashley I. Bush and Dominic J. Hare
Metallomics, 2015,7, 1213-1228
DOI: 10.1039/C5MT00075K, Critical Review

The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro
Alfred A. Hummer and Annette Rompel
Metallomics, 2013,5, 597-614
DOI: 10.1039/C3MT20261E, Tutorial Review

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson’s disease
Eleonora Carboni and Paul Lingor
Metallomics, 2015,7, 395-404
DOI: 10.1039/C4MT00339J, Minireview

A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin
Kogularamanan Suntharalingam, Oscar Mendoza, Alexandra A. Duarte, David J. Mann and Ramon Vilar
Metallomics, 2013,5, 514-523
DOI: 10.1039/C3MT20252F, Paper

Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion
Gordon W. Irvine, Tyler B. J. Pinter and Martin J. Stillman
Metallomics, 2016,8, 71-81
DOI: 10.1039/C5MT00225G, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Open Access papers in Metallomics

We are very pleased to share with you below some of the latest Open Access papers published in Metallomics that may be of interest to you. These research papers are free to access for all – we hope you enjoy reading them.

The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans
Dietrich H. Nies
Metallomics, 2016,8, 481-507
DOI: 10.1039/C5MT00320B, Tutorial Review

Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol
Kristine L. Kay, Chris J. Hamilton and Nick E. Le Brun
Metallomics, 2016, Advance Article
DOI: 10.1039/C6MT00036C, Paper

Chemistry of bone remodelling preserved in extant and fossil Sirenia
Jennifer Anné, Roy A. Wogelius, Nicholas P. Edwards, Arjen van Veelen, Konstantin Ignatyev and Phillip L. Manning
Metallomics, 2016,8, 508-513
DOI: 10.1039/C5MT00311C, Paper

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
Ekaterina Schreiber-Brynzak, Verena Pichler, Petra Heffeter, Buck Hanson, Sarah Theiner, Irene Lichtscheidl-Schultz, Christoph Kornauth, Luca Bamonti, Vineet Dhery, Diana Groza, David Berry, Walter Berger, Markus Galanski, Michael A. Jakupec and Bernhard K. Keppler
Metallomics, 2016,8, 422-433
DOI: 10.1039/C5MT00312A, Paper

Lead and manganese levels in serum and erythrocytes in Alzheimer’s disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
Dominic J. Hare, Noel G. Faux, Blaine R. Roberts, Irene Volitakis, Ralph N. Martins and Ashley I. Bush
Metallomics, 2016,8, 628-632
DOI: 10.1039/C6MT00019C, Paper

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS
J. B. Hilton, A. R. White and P. J. Crouch
Metallomics, 2016, Advance Article
DOI: 10.1039/C6MT00099A, Paper

Surface binding, localization and storage of iron in the giant kelp Macrocystis pyrifera
Eric P. Miller, Hendrik Auerbach, Volker Schünemann, Teresa Tymon and Carl J. Carrano
Metallomics, 2016,8, 403-411
DOI: 10.1039/C6MT00027D, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Expanded Nickel in Biology online collection now available

The Nickel in Biology online collection has now been expanded to include additional reports in this field which highlight emerging high-impact research on the roles and distribution of nickel in biology.

Curated by Editorial Board member Professor Deborah Zamble, the hope is that the collection will become a resource for researchers in the field and new articles will be added to this collection as they are published in Metallomics.

A link to the collection can be found here.

Do you work in this area? Then why not submit to Metallomics today!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Editor’s Choice: Chris Orvig selects his top papers from recent issues of Metallomics

Metallomics Editorial Board Member, Professor Chris Orvig (University of British Columbia) selects his Top 5 articles from recent issues of Metallomics.

Professor Orvig is Director of the Medicinal Inorganic Chemistry Group and Professor of Chemistry and Pharmaceutical Sciences at the University of British Columbia. His research interests are medicinal inorganic chemistry and coordination chemistry and he has been involved over the years with radiopharmaceutical chemistry, metal ion decorporation, and metal ion neurotoxicology, as well as chemotherapeutic metal complexes and ligands.

Read Professor Orvig’s Editor’s Choice selection via the links below – all articles are free to access for the next 4 weeks!


The role of vanadium in biology

Dieter Rehder, Metallomics, 2015, 7, 730, DOI: 10.1039/c4mt00304g

A timely and comprehensive review, from one of the world’s experts, on relevant bioinorganic chemistry of vanadium, an element of many roles and even more questions.  The review highlights the many roles of vanadium in nature and biology, including its transport, speciation, redox, acquisition and natural sources, as well as medicinal applications.  A detailed readable and timely account.

Boron uptake, localization, and speciation in marine brown algae

Eric P. Miller et al., Metallomics, 2016, 8, 161, DOI: 10.1039/c5mt00238a

Boron’s marine concentrations exceed those in its terrestrial environments significantly and yet it is a required element throughout the plant kingdom.  This paper examines boron in two species of brown algae looking at uptake, localization, and speciation with a variety of physical techniques (including 11B NMR) concluding that it is bound to cell walls (possibly as alginate) and as mannitol esters.

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Stuart D. Portbury et al., Metallomics, 2016, 8, 193, DOI: 10.1039/c5mt00234f

An unusual study of the “metallo-pathological” features of traumatic brain injury including increased brain concentrations of non-heme Fe and free Zn.  The study examines regional and time point specific elevations in Fe, Zn and Cu that were detected immediately and up to 28 days after a controlled cortical impact; such an impact results in both significant and sustained alterations in normal metal levels in the brain. A brutal but fascinating study.

LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs

Sarah Theiner et al., Metallomics, 2016, 8, 398, DOI: 10.1039/c5mt00276a

An interesting proof-of-principle combination of a hyphenated mass spectrometry technique for elemental imaging with tumour spheroids, a useful macroscopic three dimensional cancer cell model, to examine Pt drug accumulation from three anti-tumour agents.  Excellent spatial resolution allowed imaging of Pt on the periphery and in the necrotic core of the spheroids, as well as estimations of drug penetration of the tumours.

Chemistry of bone remodelling preserved in extant and fossil Sirenia

Jennifer Anné et al., Metallomics, 2016, 8, 508, DOI: 10.1039/c5mt00311c

A combination of high energy X-ray techniques is used to characterise, localize and quantify trace elements (particularly Ca and Zn) within bone tissues of aquatic mammals (e.g. manatees). Their dense bone structure showed concentrations of the elements to be comparable whether extant or fossil material was studied suggesting distributions, concentrations, and chemical coordination of the elements indicate the chemistry of bone remodelling has been preserved for 19 million years.  A most unusual and potentially broad-reaching study.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Themed issue on the neurochemistry of lead and manganese now published

The new themed issue for Metallomics titled “Neurochemistry of lead and manganese” is now published.

This themed collection, guest edited by Professor Rachel Austin, Professor Jennifer Freeman and Professor Tomas Guilarte, highlights the molecular mechanisms by which lead and manganese impact the central nervous system.

We hope you enjoy the issue!

Why not submit your high impact research to Metallomics today. Information about the scope of the Journal can be found here.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Call for papers: Imaging Metals in Biology

You are invited to contribute to the upcoming Metallomics themed issue titled “Imaging Metals in Biology“.

Guest Edited by Dr Dominic Hare (University of Technology Sydney, Australia), Dr Gawain McColl (Florey Institute of Neuroscience and Mental Health, Australia) and Dr Elizabeth New (The University of Sydney, Australia) this upcoming themed issue will showcase the current state-of-play in metal imaging by presenting applications that provide new understanding of how metals regulate normal biochemistry and how this critical balance is lost during disease.

Imaging metals in biological systems has evolved beyond method development to applications which are relevant to fundamental cell biology and making significant contributions to health and disease research. Showcasing these cutting-edge approaches and insights will provide the basis for new studies into the metallome and the effects metals ions have on organisms on other omic-level phenotypes including the proteome and metabolome.

For your article to be considered for this themed issue we must receive your manuscript by October 2nd 2016.

Communications, Full Papers and Review articles are welcomed, if you are interested in submitting an article please contact us to let us know.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

13th European Biological Inorganic Chemistry Conference

Graphical abstract

The 13th European Biological Inorganic Chemistry Conference (EuroBIC 13) is due to take place at the ELTE Convention Centre, Budapest between 28th August – 1st September 2016.

Topics to be covered:

Bio-coordination chemistry: complexes of peptides, nucleotides and related ligands
Bioinorganic Chemistry and Nanotechnology
Biomineralization
Metals in the Environment
Metals in medicine, diagnosis and therapy
Metabolism of Metal ions; and metal ion sensing in biology
Metalloenzymes, structure, function and models
Metalloproteins
Metals in the Brain
Spectroscopy and diffraction
Metal ions in nucleic acid structure and folding

For more information about the conference and to register your interest, please see their website: http://www.eurobic13.mke.org.hu/

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)