Our themed issue on Metal Toxicity is now online! Guest Edited by Chris Rensing of the University of Arizona and Gregor Grass of the Bundeswehr Institute of Microbiology, this issue contains a collection of reviews and research papers on an important and sometimes controversial topic.
Chris and Gregor introduce the issue in their Editorial:
The front cover of the issue features a Minireview from Oded Lewinson and Joshua Klein of the Technion-Israel Institute of Technology, Haifa, Israel. They look at bacterial ATP-driven transporters of transition metals and discuss how each system is adapted to perform its specific task from mechanistic and structural perspectives. Despite the differences, there is one important commonality: in many clinically relevant bacterial pathogens, transporters of transition metals are essential for virulence.
Minireview: Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
Joshua S. Klein and Oded Lewinson
Featured on the inside front cover is a Critical Review from Raymond Turner and colleagues from the University of Calgary, Alberta, Canada which explains the ‘-omics’ approach of metabolomics and how it can be applied to study a physiological response to toxic metal exposure. A frank evaluation of the approach is given to provide newcomers to the method a clear idea of the challenges and the rewards of applying metabolomics to their research.
Critical Review: Metabolomics and its application to studying metal toxicity
Sean C. Booth, Matthew L. Workentine, Aalim M. Weljie and Raymond J. Turner
The cover articles will be free for 6 weeks, and do take a look at the full themed issue.
We’d like to thank the Guest Editors and all the authors for their contribution to putting the issue together, and we hope that you enjoy reading it.