Read this interesting review from Leonid Breydo and Vladimir Uversky exploring timely and important questions surrounding the interaction of metal ions with intrinsically unstable proteins and how this leads to protein fibrillation. Research in this area is paramount for understanding neurodegenerative diseases such as Parkinson’s, Alzheimer’s and prion disease, and hence developing protective strategies for them.
You can read the review for free until 6th October.
Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
Leonid Breydo and Vladimir N. Uversky
Breydo and Uversky mention a couple of papers from our Metals in Neurodegenerative Disease themed issue that we published earlier this year:
Interactions of Zn(II) and Cu(II) ions with Alzheimer’s amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity
Vello Tõugu, Ann Tiiman and Peep Palumaa
Metallomics, 2011, 3, 250-261
Role of metal dyshomeostasis in Alzheimer’s disease
David J. Bonda, Hyoung-gon Lee, Jeffrey A. Blair, Xiongwei Zhu, George Perry and Mark A. Smith
Metallomics, 2011, 3, 267-270
Recap on Vladimir’s other Metallomics critical review from last year…
Metalloproteomics and metal toxicology of α-synuclein
Aaron Santner and Vladimir N. Uversky
Metallomics, 2010, 2, 378-392