Archive for the ‘Hot Article 2013’ Category

Trace elements in sulfidic waters

Structures of Fe-Mo-S complexes

In aquatic ecosystems, nutrients in the form of trace elements such as iron, molybdenum and copper play fundamental roles in important biological processes including nitrogen fixation, nitrate assimilation and N2O decomposition.
In oxygen bearing water these trace elements are predominantly found in their highest oxidation states in the form of environmentally mobile (hydr)oxyanions. In sulfide bearing waters with poor ventilation, (hydr)oxyanions are no longer stable and are either reduced rapidly by sulfide or transformed to thioanions without reduction.

In this hot article by George Helz from the University of Maryland and colleagues at the Minnesota State University address the mechanisms which prevented the trace elements nutrients being lost from marine environments as insoluble sulfides, during times when large parts the Earth’s oceans were sulfidic.

To read the full article, please access the link below. This paper will be free to read until 17 December 2013.

Stabilities of thiomolybdate complexes of iron; implications for retention of essential trace elements (Fe, Cu, Mo) in sulfidic waters
George R. Helz, Britt E. Ericksona and Trent P. Vorlicek
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00217A

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Importance of conserved residue in human copper chaperone

Understanding copper-binding properties

Copper is one of the most abundant metals in the human body and it takes part in a number of biological processes. Because both copper deficiency and excess can cause serious health problems, copper homeostasis is tightly regulated. Therefore, monitoring the use and transfer of copper in the human body is of great interest to scientists.

To understand how copper is transported into the cells, Changlin Tian and Yangzhong Liu at the University of Science and Technology of China investigated a mutation of copper chaperone Atox1 which affects the conserved residue Lys60. Lys60 plays an important role in the formation of protein heterodimers and determines the copper transfer to the target protein. In their study, the researchers used NMR and protein dynamic studies and indicated that the mutation causes crucial structural changes that affect the metal-binding centres and the protein flexibility. These results indicate that the residue Lys60 preserves the structure and dynamics of Atox1 and thus the protein’s ability to bind copper and deliver it to the target protein.

To know more about this work, please access the link below. This paper will be free to read until November 15th .

Conserved residue modulates copper-binding properties through structural dynamics in human copper chaperone Atox1
Zhaoyong Xi, Chaowei Shi, Changlin Tian and   Yangzhong Liu
Metallomics, 2013, 5, 1566-1573
DOI: 10.1039/C3MT00190C

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Free HOT articles in Metallomics

Take a look at the new HOT articles just published in Metallomics! All these papers will be free to read for the next three weeks. Enjoy!

Speciation and identification of tellurium-containing metabolites in garlic, Allium sativum
Yasumi Anan, Miyuki Yoshida, Saki Hasegawa, Ryota Katai, Maki Tokumoto, Laurent Ouerdane, Ryszard Łobiński and Yasumitsu Ogra  
Metallomics, 2013,5, 1215-1224
DOI: 10.1039/C3MT00108C

The oxidation states and chemical environments of iron and zinc as potential indicators of brain tumour malignancy grade – preliminary results
Aleksandra Wandzilak, Mateusz Czyzycki, Pawel Wrobel, Magdalena Szczerbowska-Boruchowska, Edyta Radwanska, Dariusz Adamek and Marek Lankosza  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00158J

Contrasting Cu, Fe, and Zn isotopic patterns in organs and body fluids of mice and sheep, with emphasis on cellular fractionation
Vincent Balter, Aline Lamboux, Antoine Zazzo, Philippe Télouk, Yann Leverrier, Jacqueline Marvel, Aidan P. Moloney, Frank J. Monahan, Olaf Schmidt and Francis Albarèdea  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00151B

Mercury(II) complex formation with N-acetylcysteine
Farideh Jalilehvand, Karnjit Parmara and Stephen Zielke  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00173C

Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients
Gail R. Willsky, Katherine Halvorsen, Michael E. Godzala III, Lai-Har Chi, Mathew J. Most, Peter Kaszynski, Debbie C. Crans, Allison B. Goldfined and Paul J. Kostyniaka  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00162H

Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells
Lisa Passantino, Alexandra B. Muñoza and Max Costa  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00149K

X-ray fluorescence imaging of the hippocampal formation after manganese exposure
Gregory Robison, Taisiya Zakharova, Sherleen Fu, Wendy Jiang, Rachael Fulper, Raul Barrea, Wei Zheng and Yulia Pushkar  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00133D

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Themed Issue on Plant Metallomics now published

Peroza et al., Metallomics, 2013, 5, 1204-1214

The Themed issue of Metallomics on Plant metallomics has now been published!

Take a look at the Editorial of the issue, written by Guest Editor David Salt. This themed issue contains eight reviews and twelve research papers and provides a good overview of works on genes, small metabolites and proteins involved in the mineral nutrient and trace element homeostasis in plants. Papers highlighting some of the analytical techniques used to make such discoveries are also included.

Hermans et al., Metallomics, 2013, 5, 1170-1183

Below are the HOT articles of the issue, free to read for the next three weeks. To access the full articles, just click on the links:

An update on magnesium homeostasis mechanisms in plants
Christian Hermans, Simon J. Conn, Jiugeng Chen, Qiying Xiao and Nathalie Verbruggen
Metallomics, 2013,5, 1170-1183
DOI: 10.1039/C3MT20223B

Transition metals in plant photosynthesis
Inmaculada Yruela 
Metallomics, 2013,5, 1090-1109
DOI: 10.1039/C3MT00086A

Model of how plants sense zinc deficiency
Ana G. L. Assunção, Daniel P. Persson, Søren Husted, Jan K. Schjørring, Ross D. Alexander and Mark G. M. Aarts 
Metallomics, 2013,5, 1110-1116
DOI: 10.1039/C3MT00070B

Leszczyszyn et al., Metallomics, 2013, 5, 1146-1169

Diversity and distribution of plant metallothioneins: a review of structure, properties and functions
Oksana I. Leszczyszyn, Hasan T. Imam and Claudia A. Blindauer
Metallomics, 2013,5, 1146-1169
DOI: 10.1039/C3MT00072A

Metal ion release from metallothioneins: proteolysis as an alternative to oxidation
Estevão A. Peroza, Augusto dos Santos Cabral, Xiaoqiong Wan and Eva Freisinger
Metallomics, 2013,5, 1204-1214
DOI: 10.1039/C3MT00079F

Speciation and identification of tellurium-containing metabolites in garlic, Allium sativum
Yasumi Anan, Miyuki Yoshida, Saki Hasegawa, Ryota Katai, Maki Tokumoto, Laurent Ouerdane, Ryszard Łobińskib and Yasumitsu Ogra  
Metallomics, 2013,5, 1215-1224
DOI: 10.1039/C3MT00108C

Zinc export results in adaptive zinc tolerance in the ectomycorrhizal basidiomycete Suillus bovinus
Joske Ruytinx, Hoai Nguyen, May Van Hees, Michiel Op De Beeck, Jaco Vangronsveld, Robert Carleer, Jan V. Colpaert and Kristin Adriaensen
Metallomics, 2013,5, 1225-1233
DOI: 10.1039/C3MT00061C

Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings
Nuria Andrés-Colás, Ana Perea-García, Sonia Mayo de Andrés, Antoni Garcia-Molina, Eavan Dorcey, Susana Rodríguez-Navarro, Miguel A. Pérez-Amador, Sergi Puig and Lola Peñarrubia 
Metallomics, 2013,5, 1234-1246
DOI: 10.1039/C3MT00025G

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HOT Articles in Metallomics

These articles will be free for you for the next three weeks. Click on the links below!

Novel surface associated polyphosphate bodies sequester uranium in the filamentous, marine cyanobacterium, Anabaena torulosa
Celin Acharya and   Shree Kumar Apte
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00139C

Synthesis of [PtCl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes and their in vitro anticancer properties
Van Vo, Ontida Tanthmanatham, Haesook Han, Pradip K. Bhowmik and Bryan L. Spangelo
Metallomics, 2013,5, 973-987
DOI: 10.1039/C3MT00128H

The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B
Roohangiz Safaei, Preston L. Adams, Ryan A. Mathews, Gerald Manorek and Stephen B. Howell 
Metallomics, 2013,5, 964-972
DOI: 10.1039/C3MT00131H

Model of how plants sense zinc deficiency
Ana G. L. Assunção, Daniel P. Persson, Søren Husted, Jan K. Schjørring, Ross D. Alexander and Mark G. M. Aarts 
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00070B

Metal ion release from metallothioneins: proteolysis as an alternative to oxidation
Estevão A. Peroza, Augusto dos Santos Cabral, Xiaoqiong Wan and Eva Freisinger
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00079F

Metallomics for drug development: an integrated CE-ICP-MS and ICP-MS approach reveals the speciation changes for an investigational ruthenium(III) drug bound to holo-transferrin in simulated cancer cytosol
Svetlana S. Aleksenko, Magdalena Matczuk, Xifeng Lu, Lidia S. Foteeva, Katarzyna Pawlak, Andrei R. Timerbaev and Maciej Jarosz
Metallomics, 2013,5, 955-963
DOI: 10.1039/C3MT00092C

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HOT Articles in Metallomics!

Take a look at our selected HOT Articles just published in Metallomics! They are all free for you to read until July 15th. Have a read now!

Association of arsenic with nutrient elements in rice plants
Guilan Duan, Wenju Liu, Xueping Chen, Ying Hu and   Yongguan Zhu  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT20277A

Transition metals in plant photosynthesis
Inmaculada Yruela
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00086A

Characterization of mercury-containing protein in human plasma
Zhaojun Yun, Lu Li, Lihong Liu, Bin He, Xingchen Zhao and   Guibin Jiang  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00036B

Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1
Chak Ming Sze, Zhenyu Shi, George N. Khairallah, Linda Feketeová, Richard A. J. O’Hair, Zhiguang Xiao, Paul S. Donnelly and   Anthony G. Wedd
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00082F

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HOT Articles in Metallomics

Take a look at our new selected HOT articles just published in Metallomics. These papers will be free to read until June 17th. Have a read now!

Evaluation of quantitative probes for weaker Cu(I) binding sites completes a set of four capable of detecting Cu(I) affinities from nanomolar to attomolar
Zhiguang Xiao, Lisa Gottschlich, Renate van der Meulen, Saumya R. Udagedara and Anthony G. Wedd  
Metallomics, 2013,5, 501-513
DOI: 10.1039/C3MT00032J 

Improved selectivity of ZnNa3DTPA vs. Na5DTPA to abstract Cd2+ from plasma proteins in vitro
Elham Zeini Jahromi and Jürgen Gailer 
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00034F

Characterization of mercury-containing protein in human plasma
Zhaojun Yun, Lu Li, Lihong Liu, Bin He, Xingchen Zhao and Guibin Jiang  
Metallomics, 2013, Accepted Manuscript
DOI: 10.1039/C3MT00036B 

Antioxidant promotion of tyrosine nitration in the presence of copper(II)
Liang Qiao, Baohong Liu and Hubert H.Girault 
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00048F

Zinc export results in adaptive zinc tolerance in the ectomycorrhizal basidiomycete Suillus bovinus
Joske Ruytinx, Hoai Nguyen, May Van Hees, Michiel Op De Beeck, Jaco Vangronsveld, Robert Carleer, Jan V. Colpaert and Kristin Adriaensen  
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00061C

Diversity and distribution of plant metallothioneins: a review of structure, properties and functions
Oksana I. Leszczyszyn, Hasan T. Imam and Claudia A. Blindauer
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00072A

Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc
Zhen Huang, Xiao-an Zhang, Miquel Bosch, Sarah J. Smith and   Stephen J. Lippard
Metallomics, 2013,5, 648-655
DOI: 10.1039/C3MT00103B

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Exploring the Activity of Metallo-drugs

Measuring anticancer activity in vitro

New compounds based on silver and palladium have been recently developed and tested in vitro for anticancer and antibacterial activity.

Rosenani Haque and colleagues at the University Sains of Malaysia synthesised Ag(I)– and Pd(II)–N-heterocyclic carbene (NHC) complexes derived from imidazole-2-ylidenes and characterised their structures by X-ray diffraction and NMR.
All the compunds showed antimicrobial activity against Staphylococcus aureus and Escherichia coli while only one of the trans-Pd(II)–NHC complex displayed significant anticancer activity.

To know more about this study, please access the full article below. This paper will be free to read until June 17th.

Sterically tuned Ag(I)- and Pd(II)-N-heterocyclic carbene complexes of imidazol-2-ylidenes: synthesis, crystal structures, and in vitro antibacterial and anticancer studies
Rosenani A. Haque, Abbas Washeel Salman, Srinivasa Budagumpi, Amirul Al-Ashraf Abdullah and   Amin M. S. Abdul Majid 
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00051F

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Iron and Manganese in yeast mitochondria

Liquid chromatography (LC)-Inductively coupled plasma mass spectrometry (ICPMS) for metal distribution

Spectroscopic methods can be used to evaluate distribution of metals in the mitochondria of yeast cells.

Paul Lindahl and colleagues at the Texas A&M University, USA, investigated the function of the Mtm1p, a carrier protein found in the yeast Saccharomyces cervisiae. Deleting the Mtm1p gene, they evaluated the iron and manganese presence in the cells and discovered that iron and manganese accumulate in mitochondria and inactivate the enzyme Mn-superoxide dismutase. Metal concentrations in cells and mitochondria were efficiently measured using inductively coupled plasma mass spectrometry.

To know more about this research, please access the full article below. This paper will be free to read until May 24th.

Insights into the iron-ome and manganese-ome of Δmtm1 Saccharomyces cerevisiae mitochondria Jinkyu
Park, Sean P. McCormick, Mrinmoy Chakrabarti and   Paul A. Lindahl 
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT00041A

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Using XAS and micro-SXRF to study anti-cancer metal compounds

Investigating anti-cancer metal compounds in vivo and in vitro with XAS and micro-SXRF

X-ray absorption spectroscopy (XAS) and micro-synchrotron based X-ray fluorescence (micro-SXRF) are valuable tools for the investigation of changes in the chemical environment of metal centres.

This tutorial review, written by Alfred Hummer and Annette Rompel from the University of Vienna, Austria, introduces the use of XAS and micro-SXRF techniques into the field of inorganic medicinal chemistry.

Currently, several review articles are available on the anti-tumoural activity of metal complexes as well as the application of XAS and micro-SXRF in biological systems. This new review provides a glimpse into the possibilities, applications and outcomes of these spectroscopic techniques in metal based cancer research. In particular, the authors describe the latest results of XAS and micro- SXRF in vitro and in vivo investigations and discuss the proposed modes of action of compounds based on platinum, ruthenium, gallium, gold and cobalt.

To read the full article, please access the link below. This paper will be free to read until May 14th.

The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro
Alfred A. Hummer and   Annette Rompel
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT20261E

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