Archive for the ‘Hot Article’ Category

Recent HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Morphological analysis of the pancreas and liver in diabetic KK-Ay mice treated with zinc and oxovanadium complexesMorphological analysis of the pancreas and liver in diabetic KK-Ay mice treated with zinc and oxovanadium complexes
Takayasu Moroki, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Airo Tsubura and Hiroyuki Yasui
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00087K

KRAS NF-κB is involved in the development of zinc resistance and reduced curability in prostate cancer

Monika Holubova, Martina Axmanova, Jaromir Gumulec, Martina Raudenska, Marketa Sztalmachova, Petr Babula, Vojtech Adam, Rene Kizek and Michal Masarik
Metallomics, 2014,6, 1240-1253
DOI: 10.1039/C4MT00065J

Roles for root iron plaque in sequestration and uptake of heavy metals and metalloids in aquatic and wetland plants

Rudra D. Tripathi, Preeti Tripathi, Sanjay Dwivedi, Amit Kumar, Aradhana Mishra, Puneet S. Chauhan, Gareth J. Norton and Chandra S. Nautiyal
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00111G

Quantification of pharmaceutical peptides using selenium as an elemental detection label

Laura Hyrup Møller, Charlotte Gabel-Jensen, Henrik Franzyk, Jesper Søborg Bahnsen, Stefan Stürup and Bente Gammelgaard
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00085D

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Imaging of intracellular metal partitioning in marine diatoms exposed to metal pollution: consequences to cellular toxicity and metal fate in the environment
Rita M. Godinho, Maria Teresa Cabrita, Luís C. Alves and Teresa Pinheiro  
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00105B, Paper

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex
Vojtech Novohradsky, Lenka Zerzankova, Jana Stepankova, Anna Kisova, Hana Kostrhunova, Zhe Liu, Peter J. Sadler, Jana Kasparkova and Viktor Brabec 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00112E, Paper

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice
Alexander E. Egger, Sarah Theiner, Christoph Kornauth, Petra Heffeter, Walter Berger, Bernhard K. Keppler and Christian G. Hartinger 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00072B, Paper

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase
Zuandi Luo, Lianling Yu, Fang Yang, Zhennan Zhao, Bo Yu, Haoqiang Lai, Ka-Hing Wong, Sai-Ming Ngai, Wenjie Zheng and Tianfeng Chen 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00044G, Paper

A comprehensive biological insight of trinuclear copper(II)–tin(IV) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies
Yusra Zaidi, Farukh Arjmand, Nida Zaidi, Jawed Ahmad Usmani, Haseeb Zubair, Kafil Akhtar, Mobarak Hossain and G. G. H. A. Shadab 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00035H, Paper

XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats
Claire M. Weekley, Anu Shanu, Jade B. Aitken, Stefan Vogt, Paul K. Witting and Hugh H. Harris 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00088A, Paper

Zinc ions modulate protein tyrosine phosphatase 1B activity
Elisa Bellomo, Alberto Massarotti, Christer Hogstrand and Wolfgang Maret 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00086B, Paper

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene–gold(I) complex
Pavlo Holenya, Suzan Can, Riccardo Rubbiani, Hamed Alborzinia, Anja Jünger, Xinlai Cheng, Ingo Ott and Stefan Wölfl  
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00075G, Paper

Imbalance of iron influx and efflux causes brain iron accumulation over time in the healthy adult rat
Jie-Hua Chen, Nadia Singh, Huimin Tay and Thomas Walczyk 
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00054D, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Zinc ruled out as biomarker for Alzheimer’s disease

The role of zinc in Alzheimer’s disease (AD) is a much debated topic and the potential of zinc as an AD biomarker has come under scrutiny in recent years. Now scientists in Australia have added to evidence that no change in serum zinc concentration is seen in AD, and that decreasing zinc levels are instead a sign of ageing.

AD, the most common form of dementia, affects millions of people worldwide, and with limited treatments available, much effort is being devoted towards new therapies and early diagnosis. The identification of AD biomarkers in the blood is an attractive goal for researchers developing new diagnostic tools, and given its potential implications in the disease, zinc appeared to be a good candidate. However, conflicting studies appear in the literature, with significance increases, decreases, as well as no significant changes, all being reported.

To read the full article by Kirsty Muirhead, please visit Chemistry World

Decreased serum zinc is an effect of ageing and not Alzheimer’s disease
Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush and Blaine R. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00060A, Communication

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Cu binding by the Escherichia coli metal-efflux accessory protein RcnB
Camille Blériot, Manon Gault, Erwan Gueguen, Pascal Arnoux, David Pignol, Marie-Andrée Mandrand-Berthelot and Agnès Rodrigue
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00036F, Paper

Leaf metallome preserved over 50 million years
N. P. Edwards, P. L. Manning, U. Bergmann, P. L. Larson, B. E. van Dongen, W. I. Sellers, S. M. Webb, D. Sokaras, R. Alonso-Mori, K. Ignatyev, H. E. Barden, A. van Veelen, J. Anné, V. M. Egerton and R. A. Wogelius Graphical abstract: Leaf metallome preserved over 50 million years
Metallomics, 2014,6, 774-782
DOI: 10.1039/C3MT00242J, Paper

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells
Sabine H. van Rijt, Isolda Romero-Canelón, Ying Fu, Steve D. Shnyder and Peter J. Sadler
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00034J, Paper

Decreased serum zinc is an effect of ageing and not Alzheimer’s disease
Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush and Blaine R. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00060A, Communication

A variety of roles for versatile zinc in metallo-β-lactamases
A. I. Karsisiotis, C. F. Damblon and G. C. K. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00066H, Critical Review Graphical abstract: Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells

Metallomics of two microorganisms relevant to heavy metal bioremediation reveal fundamental differences in metal assimilation and utilization
W. Andrew Lancaster, Angeli Lal Menon, Israel Scott, Farris L. Poole, Brian J. Vaccaro, Michael P. Thorgersen, Jil Geller, Terry C. Hazen, Richard A. Hurt, Steven D. Brown, Dwayne A. Elias and Michael W. W. Adams
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00050A, Paper

In vitro toxicological characterisation of three arsenic-containing hydrocarbons
S. Meyer, M. Matissek, S. M. Müller, M. S. Taleshi, F. Ebert, K. A. Francesconi and T. Schwerdtle
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00061G, Paper

Zinc’ing sensibly: controlling zinc homeostasis at the transcriptional level
Sangyong Choi and Amanda J. Bird
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00064A, Critical Review

To view these article for free, please register for a free RSC account here

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

A 50 million year old snapshot of leaf chemistry

Image of a leafUnderstanding the past lets us rationalise the present and plan for the future. For the trivial it can be pretty simple, what time you need to leave home to get to the office, or when you’ll next need to buy milk are pretty easy to predict based on past events. For more complex systems, over larger timescales, things can get a little more complicated.

Studying the chemical processes and biological pathways in plant life is crucial if we are to understand the living world around us; how it was, how it is and how it will be. Researchers from University of Manchester, Diamond Light Source and the Stanford Synchrotron Radiation Lightsource have studied the metallome of a 50 million year old leaf and remarkably have shown that the metal distribution correlates to the original leaf biochemistry.

Using synchrotron rapid scanning X-ray fluorescence (SRS-XRF), a non-destructive technique, the team have revealed for the first time the metallome of a fossilised plant. “This opens up the possibility to study part of the biochemistry of ancient plants, so in the future, it may enable us [to] observe the changes, if any, in the use of metals by the plant kingdom through geological time” explains Dr Nicholas Edwards, lead author of the study.

You can read more about the team’s research by downloading their open access article below, or for information on the research project and quotes from the scientific team, head over to the University of Manchester’s website.

Leaf metallome preserved over 50 million years
N. P. Edwards, P. L. Manning, U. Bergmann, P. L. Larson, B. E. van Dongen, W. I. Sellers, S. M. Webb, D. Sokaras, R. Alonso-Mori, K. Ignatyev, H. E. Barden, A. van Veelen, J. Anné, V. M. Egerton and R. A. Wogelius
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00242J

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Uncovering the Role of Serum Ferritin: A Resolution to a Paradox?

Schematic overview of the Role of Ferritin in Iron Metabolism

Overview of the Role of Ferritin in Iron Metabolism

This post was written By Pui Sai Lau, Web Writer.
While ferritin is understood to be an intracellular protein required for the storage and controlled release of iron, its role as an inflammatory disease marker is unclear. Perplexingly, though ferritin is not created in serum, it is present there and the level of serum ferritin is often measured to indicate the iron status of a patient. However, to suitably use serum ferritin as a disease marker, a number of questions first need to be addressed. Does serum ferritin directly cause inflammation or is it a by-product of another cellular mechanism? What exactly is the role of ferritin in iron metabolism? Douglas B. Kell from the University of Manchester, UK and Etheresia Pretorius from the University of Pretoria, South Africa examine what is currently known about serum ferritin to deduce its possible role in biology, and evaluate its role as a marker of disease. Read their perspective by accessing link below. Do you agree or disagree with their conclusion? Share your thoughts by leaving a comment.

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells
Douglas B. Kell and Etheresia Pretorius
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00347G, Perspective

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy! Graphical abstract: Challenging conventional wisdom: single domain metallothioneins

Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes
Zhaoyong Xi, Wei Guo, Changlin Tian, Fuyi Wang and Yangzhong Liu
Metallomics, 2014,6, 491-497
DOI: 10.1039/C3MT00338H, Paper

Challenging conventional wisdom: single domain metallothioneins
Duncan E. K. Sutherland and Martin J. Stillman
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00216K, Critical Review

Arsenic-induced suppression of kidney cell proliferation and the transcriptional coregulator MAML1
A. Pournara, T. Holmlund, Y. Lu, R. Ceder, M. Putnik, R. Grafström, M. Vahter and A. E. Wallberg
Metallomics, 2014,6, 498-504
DOI: 10.1039/C3MT00333G, Paper

An integrated study of the affinities of the Aβ16 peptide for Cu(I) and Cu(II): implications for the catalytic production of reactive oxygen species
Tessa R. Young, Angie Kirchner, Anthony G. Wedd and Zhiguang Xiao
Metallomics, 2014,6, 505-517
DOI: 10.1039/C4MT00001C, Paper Graphical abstract: A dual-targeting, p53-independent, apoptosis-inducing platinum(ii) anticancer complex, [Pt(BDIQQ)]Cl

A dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDIQQ)]Cl
Kogularamanan Suntharalingam, Justin J. Wilson, Wei Lin and Stephen J. Lippard
Metallomics, 2014,6, 437-443
DOI: 10.1039/C3MT00364G, Paper

Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I)
Jens Brose, Sharon La Fontaine, Anthony G. Wedd and Zhiguang Xiao
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00020J, Paper

Unravelling mechanisms behind the biological activity of bis(S-citronellalthiosemicarbazonato)nickel(II)
Annamaria Buschini, Silvana Pinelli, Rossella Alinovi, Francesca Mussi, Franco Bisceglie, Claudio Rivetti, Nicola Doniselli and Giorgio Pelosi
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00345K, Paper

Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots
Fany Doustaly, Florence Combes, Julie B. Fiévet, Serge Berthet, Véronique Hugouvieux, Olivier Bastien, Iker Aranjuelo, Nathalie Leonhardt, Corinne Rivasseau, Marie Carrière, Alain Vavasseur, Jean-PierrGraphical abstract: Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana rootse Renou, Yves Vandenbrouck and Jacques Bourguignon
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00005F, Paper

Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity
Asuncion Carmona, Stéphane Roudeau, Laura Perrin, Giulia Veronesi and Richard Ortega
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00012A, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Tracing the metals in Alzheimer’s disease

PLS-DA results of metal analysis

This post has been written by Polly-Anna Ashford, a PhD student at the University of East Anglia, web-writer for Analyst and Analytical Methods and guest web-writer for Metallomics.

The role of metals in the progression of Alzheimer’s disease (AD) has been under investigation since the 1990s. Essential metals such as iron, copper and zinc have been linked to changes in proteins in AD patients. Toxic metals like arsenic and lead are also implicated, and aluminium is believed to have a significant role in degeneration. The measurement of metal concentrations in the brain is therefore an important investigative tool for AD researchers. The characterisation of metal ion complexes and metalloproteins is traditionally carried out by separation of the species by techniques such as size exclusion chromatography, followed by inductively coupled plasma mass spectrometry (ICP-MS).

1
In this study, led by Tamara García-Barrera and José Luis Gómez-Ariza at the University of Huelva, Spain, human blood serum samples were analysed by ICP-MS to establish the concentration of a range of different elements. The researchers were able to distinguish between high and low molecular weight metal species by precipitating the proteins and analysing both the supernatant and the precipitate. Samples from patients with mild cognitive impairment (MCI) and Alzheimer’s disease were compared with healthy controls. From the results of their high throughput methodology, the authors have been able to draw significant conclusions about the link between changes in brain metal concentration and the advancement of neurodegenerative processes.

You can download the full artice below, which is free to access until March 3rd

Characterization of metal profiles in serum during the progression of Alzheimer’s disease
Raúl González-Domínguez, Tamara García-Barrera and José Luis Gómez-Ariza
Metallomics, 2014, 6, 292-300
DOI: 10.1039/C3MT00301A

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free HOT articles in Metallomics!

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors
Òscar Palacios, Anna Espart, Jordi Espín, Chen Ding, Dennis J. Thiele, Sílvia Atrian and Mercè Capdevila
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00266G, Paper

Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells
Julio A. Landero Figueroa, Kavitha Subramanian Vignesh, George S. Deepe and Joseph Caruso
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00283G, Paper

A different sequence of events than previously reported leads to arsenic-induced damage in Ceratophyllum demersum L.
Seema Mishra, Hans-Joachim Stärk and Hendrik Küpper
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00317E, Paper

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans
Julia Bornhorst, Sudipta Chakraborty, Sören Meyer, Hanna Lohren, Sigrid Große Brinkhaus, Adam L. Knight, Kim A. Caldwell, Guy A. Caldwell, Uwe Karst, Tanja Schwerdtle, Aaron Bowman and Michael Aschner
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00325F, Paper

Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle
Héctor Gonzalez-Iglesias, Lydia Alvarez, Montserrat García, Carson Petrash, Alfredo Sanz-Medel and Miguel Coca-Prados
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00298E, Perspective

Proteomics of Desulfovibrio desulfuricans and X-ray absorption spectroscopy to investigate mercury methylation in the presence of selenium
Hoang-Yen Thi Truong, Yu-Wei Chen, Mazen Saleh, Susan Nehzati, Graham N. George, Ingrid J. Pickering and Nelson Belzile
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00323J, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free HOT articles in Metallomics!

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next three weeks. Enjoy!

Phylogenomic analysis of Cation Diffusion Facilitator proteins uncovers Ni2+/Co2+ transporters
Ciro Cubillas, Pablo Vinuesa, Maria Luisa Tabche and Alejandro García-de los Santos
Metallomics, 2013,5, 1634-1643
DOI: 10.1039/C3MT00204G, Paper

Intracellular co-delivery of zinc ions and plasmid DNA for enhancing gene transfection activity
Shoichiro Asayama, Kosho Matsuda, Yoichi Negishi and Hiroyoshi Kawakami
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00226H, Paper

Metal sensing and signal transduction by CnrX from Cupriavidus metallidurans CH34: role of the only methionine assessed by a functional, spectroscopic, and theoretical study
Juliette Trepreau, Cornelia Grosse, Jean-Marie Mouesca, Géraldine Sarret, Eric Girard, Isabelle Petit-Haertlein, Sandra Kuennemann, Céline Desbourdes, Eve de Rosny, Antoine P. Maillard, Dietrich H. Nies and Jacques Covès
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00248A, Paper

Distribution of trace elements in the mammalian retina and cornea by use of particle-induced X-ray emission (PIXE): localisation of zinc does not correlate with that of metallothioneins
Marta Ugarte, Geoffrey W. Grime and Neville N. Osborne
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00271C, Paper

Zinc to cadmium replacement in the prokaryotic zinc-finger domain
Gaetano Malgieri, Maddalena Palmieri, Sabrina Esposito, Vincenzo Maione, Luigi Russo, Ilaria Baglivo, Ivan de Paola, Danilo Milardi, Donatella Diana, Laura Zaccaro, Paolo Vincenzo Pedone, Roberto Fattorusso and Carla Isernia
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00208J, Paper

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function
Su Ling Leong, Tessa R. Young, Kevin J. Barnham, Anthony G. Wedd, Mark G. Hinds, Zhiguang Xiao and Roberto Cappai
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00258F, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)