Archive for the ‘Hot Article’ Category

HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

James P. Parker, Ziga Ude and Celine J. Marmion
Metallomics, 2016, 8, 43-60
DOI: 10.1039/C5MT00181A, Critical Review

Graphical Abstract


Mark R. Zierden and Ann M. Valentine
Metallomics, 2016, 8, 9-16
Gordon W. Irvine, Tyler B. J. Pinter and Martin J. Stillman
Metallomics, 2016, 8, 71-81
DOI: 10.1039/C5MT00225G, Paper

Graphical Abstract

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

Frank Thévenod and Natascha A. Wolff
Metallomics, 2016, Advance Article
DOI: 10.1039/C5MT00215J, Critical Review

Graphical Abstract


Alison G. Tebo, Lars Hemmingsen and Vincent L. Pecoraro
Metallomics, 2015, 7, 1555-1561
DOI: 10.1039/C5MT00228A, Paper

Graphical Abstract


Dominic J. Hare, Michael W. M. Jones, Verena C. Wimmer, Nicole L. Jenkins, Martin D. de Jonge, Ashley I. Bush and Gawain McColl
Metallomics, 2016, Advance Article
DOI: 10.1039/C5MT00288E, Communication

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

Yue Fu, Kevin E. Bruce, Hongwei Wu and David P. Giedroc
Metallomics, 2015, Advance Article
DOI: 10.1039/C5MT00221D

Graphical Abstract


Rocío Martinez-Vivot, Guillermo Copello, Celeste Leal, Gonzalo Piñero, Vanina Usach, Mijael Rozenszajn, Laura Morelli and Clara Patricia Setton-Avruj
Metallomics, 2015, 7, 1381-1389
DOI: 10.1039/C5MT00156K, Paper

Graphical Abstract


Kathryn M. Marshall, Marie Laval, Ortis Estacio, Damien F. Hudson, Paul Kalitsis, Arthur Shulkes, Graham S. Baldwin and Oneel Patel
Metallomics, 2015, 7, 1390-1398
DOI: 10.1039/C5MT00147A, Paper

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

Cheng-Yu Tsai, Janika K. Liebig, Igor F. Tsigelny and Stephen B. Howell
Metallomics, 2015, Advance Article
DOI: 10.1039/C5MT00131E

Graphical Abstract


Hanna Lohren, Julia Bornhorst, Hans-Joachim Galla and Tanja Schwerdtle
Metallomics, 2015, Advance Article
DOI: 10.1039/C5MT00171D
Graphical Abstract

Magdalena Matczuk, Karolina Anecka, Federica Scaletti, Luigi Messori, Bernhard K. Keppler, Andrei R. Timerbaev and Maciej Jarosz
Metallomics, 2015, 7, 1364-1370
DOI: 10.1039/C5MT00109A

Graphical Abstract


Bárbara Rita Cardoso, Blaine R. Roberts, Ashley I. Bush and Dominic J. Hare
Metallomics, 2015, 7, 1213-1228
DOI: 10.1039/C5MT00075K

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What limits the virulence of Bacillus anthracis: Zn or Mn?

14 years ago, the world was shaken up by two devastating terrorist attacks on US soil. First was, 9/11 attack on world trade centre which was followed by the postal deliveries of lethal bioweapon, Anthrax. Anthrax is an infectious disease caused by Bacillus anthracis and apart form being bioweapon, anthrax is major cause of global burden of  livestock infections as well as a latest form of contagion in injectional heroin users in Europe.

 One of the ways to go about fighting  anthrax is to understand the mechanism of virulence of the bacteria and identify the factors responsible for it. As metalloproteins play a major role in virulence of  bacteria, bacterial genes involved in metal homeostasis have been broadly demonstrated to be key virulence determinants. Bacillus anthracis expresses a putative metal import system, MntBCA, which belongs to the large family of ATP Binding Cassette (ABC) transporters and is essential for it’s virulence. Deletion of MntA, the systems substrate binding protein, yields a completely non-virulent strain. Various trace metals imported by ABC transporters such as Fe, Zn, Mn are essential to bacterial virulence and pathogenesis.

Which of these metals is involved in virulence of anthrax?

The answer to this question can be found by determining the  binding affinity of various metals to the baMntA ( the system’s high affinity substrate binding protein). In a recent article in Metallomics, Oded Lewinson et al. elucidate the first structure-function analysis of baMntA. They determined its metal binding specificity and affinities by Isothermal Titration Calorimetry (ITC) and Identified residues that participate in metal coordination.

Model structure of baMntA with proposed metal binding site

A series of ITC experiments revealed that-

  • MntA does not bind to Fe2/3+ (contrast to inference from growth complementation studies).
  • Rather , MntA binds a variety of metal ions, including Mn2+, Zn 2+, Cd2+, CO2+ and Ni2+.
  • Binding of  Zn 2+ and CO2+ have a pronounced thermo-stabilising effect on MntA, with Mn2+ having a milder effect.
  • Thermodynamic stability of MntA, metal binding and release experiments suggest that Mn2+ is the metal that is likely transported by MntBCA and is therefore the limiting factor for virulence of Bacillus anthracis.
 The binding of a metal to a protein involves various structural intricacies and each metal behaves in a different way. To know more about the binding of various metals to baMntA, read the full article for free* by following the link below.


Elena Vigonsky, Inbar Fish, Nurit Livnat-Levanon, Elena Ovcharenko, Nir Ben-Tal and Oded Lewinson
Metallomics, 2015, Advance Article
DOI: 10.1039/C5MT00100E

About the webwriter
Sushil Benke is a graduate student under the supervision of Dr. H. N. Gopi in the Department of Chemistry at Indian Institute of Science Education and Research (IISER), Pune. His research focuses on the development of novel antimicrobial peptidomimetics.

 *Access is free through a registered RSC account.

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

Graphical abstract

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines
Verena Pichler, Simone Göschl, Ekaterina Schreiber-Brynzak, Michael A. Jakupec, Markus Galanski and Bernhard K. Keppler
Metallomics, 2015, 7, 1078-1090
DOI: 10.1039/C5MT00116A, Paper

Characterization of zinc uptake by mouse primary cultured astrocytes and microglia
Shohei Segawa, Nao Tatsumi, Akihiro Ohishi, Kentaro Nishida and Kazuki Nagasawa
Metallomics, 2015, 7, 1067-1077
DOI: 10.1039/C5MT00085H, Paper

Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?

R. A. Hauser-Davis, L. V. de Freitas, D. S. Cukierman, W. S. Cruz, M. C. Miotto, J. Landeira-Fernandez, A. A. Valiente-Gabioud, C. O. Fernández and N. A. Rey
Metallomics, 2015, 7, 743-747
DOI: 10.1039/C5MT00003C, Communication

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents

Sarah Theiner, Christoph Kornauth, Hristo P. Varbanov, Markus Galanski, Sushilla Van Schoonhoven, Petra Heffeter, Walter Berger, Alexander E. Egger and Bernhard K. Keppler
Metallomics, 2015, Advance Article
DOI: 10.1039/C5MT00028A, Paper
Graphical Abstract
Quantitative elemental analysis of bovine ovarian follicles using X-ray fluorescence imaging
M. J. Ceko, K. Hummitzsch, N. Hatzirodos, R. J. Rodgers and H. H. Harris
Metallomics, 2015, 7, 828-836
DOI: 10.1039/C5MT00035A, Paper

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

Graphical Abstract

Modulating Glyoxalase I Metal Selectivity by Deletional Mutagenesis: Underlying Structural Factors Contributing to Nickel Activation Profiles
Uthaiwan Suttisansanee, Yanhong Ran, Kadia Y. Mullings, Nicole Sukdeo and John F. Honek
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00299G

Metallobiochemistry of current environmental levels of ultratrace elements: metabolic patterns of platinum group elements in the rat
E. Sabbioni, S. Fortaner, S. Manenti, F. Groppi, M. Bonardi, S. Bosisio and M. Di Gioacchino
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00240G

Elemental mapping inventory of the fish Liza aurata brain: a biomarker of metal pollution vulnerability
Rita M. Godinho, Patricia Pereira, Joana Raimundo, Mário Pacheco and Teresa Pinheiro
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00281D

Metallomics and NMR-based Metabolomics of Chlorella sp. Reveal Synergistic Role of Cu in Multi-Metal Toxicity and Oxidative Stress
Wenlin Zhang, Nicole G. J. Tan, Baohui Fu and Sam F. Y. Li
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00253A

Ni(II) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency
Nina Ewa Wezynfeld, Arkadiusz Bonna, Wojciech Bal and Tomasz Frączyk
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00316K

Overcoming concentration-dependence in responsive contrast agents for magnetic resonance imaging
Levi A. Ekanger and Matthew J. Allen
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00289J
Graphical Abstract

The discrepancy between absence of copper deposition and presence of neuronal damage in brain of Atp7b-/- mice
Yi Dong, Sheng-Sheng Shi, Sheng Chen, Wang Ni, Min Zhu and Zhi-Ying Wu
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00242C

The role of vanadium in biology
Dieter Rehder
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00304G

Novel insights into nickel import in Staphylococcus aureus: positive impact of free histidine and structural characterization of a new thiazolidine-type nickel chelator
H. Lebrette, E. Borezée-Durant, L. Martin, P. Richaud, E. Boeri Erba and C. Cavazza
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00295D

Copper Homeostasis in Mycobacterium tuberculosis
Xiaoshan Shi and K. Heran Darwin
Metallomics, 2015, Advance Article
DOI: 10.1039/C4MT00305E

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HOT articles in Metallomics

Take a look at our recent HOT Metallomics articles, these are now free to access for the next few weeks!

NUTRIENT METAL ELEMENTS IN PLANTS
Giovanni DalCorso, Anna Manara, Silvia Piasentin and Antonella Furini
Metallomics, 2014, 6, 1770-1788
DOI: 10.1039/C4MT00173G

Graphical Abstract

Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells
Anne M. Hessels and Maarten Merkx
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00179F

Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis
N. Duraipandy, Rachita Lakra, Srivatsan Kunnavakkam Vinjimur, Debasis Samanta, Purna Sai K and Manikantan Syamala Kiran
Metallomics, 2014, 6, 2025-2033
DOI: 10.1039/C4MT00165F

IRE mRNA Riboregulators Use Metabolic Iron ( Fe2+) to Control
Elizabeth C. Theil
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00136B

Fortification of blood plasma from cancer patients with human serum albumin decreases the concentration of cisplatin-derived toxic hydrolysis products in vitro
Thomas T. Morris, Yibing Ruan, Victor A. Lewis, Aru Narendran and Jürgen Gailer
Metallomics, 2014, 6, 2034-2041
DOI: 10.1039/C4MT00220B

Graphical Abstract

Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster.
S. Meyer, J. Schulz, A. Jeibmann, M. S. Taleshi, F. Ebert, K. A. Francesconi and T. Schwerdtle
Metallomics, 2014, 6, 2010-2014
DOI: 10.1039/C4MT00249K

Iron regulatory proteins and their role in controlling iron metabolism
Lukas C. Kühn
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00164H
Speciation of iron in mouse liver during development, iron deficiency, IRP2 deletion and Inflammatory hepatitis
Mrinmoy Chakrabarti, Allison L. Cockrell, Jinkyu Park, Sean P. McCormick, Lora S. Lindahl and Paul A. Lindahl
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00215F

Thioflavin-based molecular probes for application in Alzheimer’s Disease: from in silico to in vitro models
C. Rodríguez-Rodríguez, M. A. Telpoukhovskaia, J. Alí-Torres, L. Rodríguez-Santiago, Y. Manso, G. A. Bailey, J. Hidalgo, M. Sodupe and C. Orvig
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00167B

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Recent HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

An integrative computational model for large-scale identification of metalloproteins in microbial genomes: a focus on iron–sulfur cluster proteins
Johan Estellon, Sandrine Ollagnier de Choudens, Myriam Smadja, Marc Fontecave and Yves Vandenbrouck
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00156G, Paper

Metal binding properties of the zinc finger metallome – insights into variations in stability
Anna Miłoch and Artur Krężel
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00149D, Paper

Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators
Eman A. Akam, Tsuhen M. Chang, Andrei V. Astashkin and Elisa Tomat
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00153B, Paper

Copper-dependent and -independent hypoxia-inducible factor-1 regulation of gene expression
Zhen Zhang, Liying Qiu, Chen Lin, Hong Yang, Haiying Fu, Rui Li and Y. James Kang
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00052H, Paper

Evaluation of Fe uptake and translocation in transgenic and non-transgenic soybean plants using enriched stable 57Fe as a tracer
Silvana R. Oliveira, Amauri A. Menegário and Marco A. Z. Arruda
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00162A, Paper

The cation diffusion facilitator protein EmfA of Rhizobium etli belongs to a novel subfamily of Mn2+/Fe2+ transporters conserved in α-proteobacteria
Ciro Cubillas, Pablo Vinuesa, Maria Luisa Tabche, Araceli Dávalos, Alejandra Vázquez, Ismael Hernández-Lucas, David Romero and Alejandro García-de los Santos
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00135D, Paper

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Recent HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Morphological analysis of the pancreas and liver in diabetic KK-Ay mice treated with zinc and oxovanadium complexesMorphological analysis of the pancreas and liver in diabetic KK-Ay mice treated with zinc and oxovanadium complexes
Takayasu Moroki, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Airo Tsubura and Hiroyuki Yasui
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00087K

KRAS NF-κB is involved in the development of zinc resistance and reduced curability in prostate cancer

Monika Holubova, Martina Axmanova, Jaromir Gumulec, Martina Raudenska, Marketa Sztalmachova, Petr Babula, Vojtech Adam, Rene Kizek and Michal Masarik
Metallomics, 2014,6, 1240-1253
DOI: 10.1039/C4MT00065J

Roles for root iron plaque in sequestration and uptake of heavy metals and metalloids in aquatic and wetland plants

Rudra D. Tripathi, Preeti Tripathi, Sanjay Dwivedi, Amit Kumar, Aradhana Mishra, Puneet S. Chauhan, Gareth J. Norton and Chandra S. Nautiyal
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00111G

Quantification of pharmaceutical peptides using selenium as an elemental detection label

Laura Hyrup Møller, Charlotte Gabel-Jensen, Henrik Franzyk, Jesper Søborg Bahnsen, Stefan Stürup and Bente Gammelgaard
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00085D

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