Archive for the ‘Covers’ Category

Issue 8 now online

Metal imaging in neurodegenerative diseases

Front cover: Bourassa and Miller, Metallomics, 2012,4, 721-738

The latest issue of Metallomics is now online, with not one, not two but four covers:

Our colourful front cover features an article from Lisa Miller of the National Synchrotron Light Source at Brookhaven National Laboratory (New York, USA) and her Ph.D. student at Stony Brook University, Megan Bourassa. Their Critical Review highlights the advances in neurodegenerative disease research facilitated by metal imaging techniques.

Critical Review: Metal imaging in neurodegenerative diseases
Megan W. Bourassa and Lisa M. Miller
Metallomics, 2012, 4, 721-738
DOI: 10.1039/C2MT20052J

The inside front cover comes from Martin Stillman and colleagues at Western University, London, Canada. They look at the effects of metal and ring periphery substitution in the Isd protein system involved in heme transport in the pathogenic bacterium Staphylococcus aureus.

Insight into blocking heme transfer by exploiting molecular interactions in the core Isd heme transporters IsdA-NEAT, IsdC-NEAT, and IsdE of Staphylococcus aureus
Michael T. Tiedemann,  Tyler B. J. Pinter and Martin J. Stillman
Metallomics, 2012, 4, 751-760
DOI: 10.1039/C2MT20067H

Blocking heme transfer in Staphylococcus aureus

Inside front cover: Tiedemann et al., Metallomics, 2012, 4, 751-760

On the inside back cover, a paper from Christophe Biot and co-workers at the University of Lille, who used two ruthenocenic bioprobes to study the mechanism of the antimalarial drug candidate ferroquine.

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes
Christophe Biot,  Faustine Dubar,  Jamal Khalife and Christian Slomianny
Metallomics, 2012, 4, 780-783
DOI: 10.1039/C2MT20063E

And finally, on the outside back cover, Ruth Valentine and colleagues at Newcastle University present new information on the functional activity of the zinc transporter ZnT10.

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis
Helen J. Bosomworth,  Jared K. Thornton,  Lisa J. Coneyworth,  Dianne Ford and Ruth A. Valentine
Metallomics, 2012, 4, 771-779
DOI: 10.1039/C2MT20088K

All these cover articles will be free to access for 6 weeks – enjoy!


Metallomics, 2012, Issue 8, back covers

Back covers: Biot et al. (L) and Bosomworth et al. (R)

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Metallomics Issue 7 online: Metals and Genetics

Issue 7 of Metallomics is a special themed issue on Metals and Genetics. It features papers originating from the Fifth International Conference on Metals and Genetics (ICMG) held in Kobe, Japan, September 4–8, 2011. Read more about this themed issue in the wonderful introductory Editorial by Bibudhendra Sarkar.

A survey of arsenic, manganese, boron, thorium, and other toxic metals in the groundwater of a West Bengal, India neighbourhood

Sarkar et al., Metallomics, 2012, 4, 653

Metals and Genetics
Bibudhendra Sarkar
Metallomics, 2012, 4, 589-592
DOI: 10.1039/C2MT90030K

We have four wonderful covers for you to admire in this themed issue. On the outside front cover we have an image from our editorial author Bibudhendra Sarkar from The Hospital for Sick Children, Toronto, Canada, who has been working with colleagues from Canada and the US in studying drinking water in West Bengal, India.

A survey of arsenic, manganese, boron, thorium, and other toxic metals in the groundwater of a West Bengal, India neighbourhood
Thomas Bacquart, Kelly Bradshaw, Seth Frisbie, Erika Mitchell, George Springston, Jeffrey Defelice, Hannah Dustin and Bibudhendra Sarkar
Metallomics, 2012, 4, 653-659
DOI: 10.1039/C2MT20020A

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson's disease

Burkhead et al., Metallomics, 2012, 4, 660

The inside front cover has an image from Jason L. Burkhead at the University of Alaska Anchorage and a team from around the US working on Wilson’s disease which is an inherited recessive disorder that causes defective copper metabolism in the human body.

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson’s disease
Phillip A. Wilmarth, Kristopher K. Short, Oliver Fiehn, Svetlana Lutsenko, Larry L. David and Jason L. Burkhead
Metallomics, 2012, 4, 660-668
DOI: 10.1039/C2MT20017A

A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism

Ben-Tal & Lutsenko et al., Metallomics, 2012, 4, 669

On the inside back cover we have more research into Wilson’s disease by Nir Ben-Tal and Svetlana Lutsenko from Tel-Aviv University and Johns Hopkins University, respectively, who together with co-workers have been studying the copper-transporting ATPase ATP7B.

A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism
Maya Schushan, Ashima Bhattacharjee, Nir Ben-Tal and Svetlana Lutsenko
Metallomics, 2012, 4, 669-678
DOI: 10.1039/C2MT20025B

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells

Bierbach et al., Metallomics, 2012, 4, 645

To round out the collection of covers, on the outside back cover we have an image from Ulrich Bierbach from Wake Forest University, US, and colleagues who have been studying lung cancer cells, and looking at DNA damage produced by a platinum–acridine antitumor agent.

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells
Xin Qiao, Alexandra E. Zeitany, Marcus W. Wright, Amal S. Essader, Keith E. Levine, Gregory L. Kucera and Ulrich Bierbach
Metallomics, 2012, 4, 645-652
DOI: 10.1039/C2MT20031G

These cover papers will be free to read for 6 weeks. As you can see, it’s a bumper collection this month in Metallomics, so take a look at our themed issue on Metals and Genetics today!

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Metallomics Issue 6 now online!

Metallomics, Issue 6, 2012, Outside Front Cover

Hadjikakou et al., Metallomics, 2012, 4, 545

Issue 6 of Metallomics is now online for you to look at. This months issue features nanopore analysis, pharmacology, Pt complexes and more. Take a look while the articles are free to read.

On the front cover is a colourful image from Greece, where S. K. Hadjikakou from the University of Ioannina and colleagues have been working with mixed ligand-silver(I) complexes with anti-inflammatory agents.

Mixed ligand–silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis
C. N. Banti, A. D. Giannoulis, N. Kourkoumelis, A. M. Owczarzak, M. Poyraz, M. Kubicki, K. Charalabopoulos and S. K. Hadjikakou
Metallomics, 2012, 4, 545-560
DOI: 10.1039/C2MT20039B

Metallomics, Issue 6, 2012, Inside front cover

Ballihaut et al., Metallomics, 2012, 4, 533

The inside front cover features research from the National Institute of Standards and Technology in the USA. Guillaume Ballihaut and colleagues have been studying the different forms of selenoprotein P, a rather unique protein in the human body responsible for the transport and distribution of the essential trace element selenium.

Multiple forms of selenoprotein P in a candidate human plasma standard reference material
Guillaume Ballihaut, Lisa E. Kilpatrick, Eric L. Kilpatrick and W. Clay Davis
Metallomics, 2012, 4, 533-538
DOI: 10.1039/C2MT20059G

Metallomics, Issue 6, 2012, Back cover

Krasniqi & Lee, Metallomics, 2012, 4, 539

We have a back cover this month too! On the back of issue 6 you can find out about the research in nanopore analysis of proteins that is being conducted by Jeremy Lee and his colleagues at the University of Saskatchewan, Canada.

The importance of adding EDTA for the nanopore analysis of proteins
Besnik Krasniqi and Jeremy S. Lee
Metallomics, 2012, 4, 539-544
DOI: 10.1039/C2MT20050C

Other papers that you can read in the issue this month include;

Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect
Jane A. Plumb, Balaji Venugopal, Rabbab Oun, Natividad Gomez-Roman, Yoshiyuki Kawazoe, Natarajan Sathiyamoorthy Venkataramanan and Nial J. Wheate
Metallomics, 2012, 4, 561-567
DOI: 10.1039/C2MT20054F

Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES)
Matthew D. Hall, Helen L. Daly, Jenny Z. Zhang, Mei Zhang, Rebecca A. Alderden, Daniel Pursche, Garry J. Foran and Trevor W. Hambley
Metallomics, 2012, 4, 568-575
DOI: 10.1039/C2MT20053H

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Issue 5 of Metallomics now online

The latest issue of Metallomics in now available online for you to browse.  Featuring nucleic acid chemistry, pharmaceuticals, metabolomics, metals in plants and much more!

Metallomics, Issue 5, 2012, Outside front coverOn the front cover is research from Korea by Hyosun Lee and Seog K. Kim from Kyungpook National University and Yeungnam University, respectively, who along with their colleagues have studied the binding modes and photo-induced DNA cleavage mechanisms of porphyrins.

Photo-induced DNA scission by Cu(II)-mesotetrakis(nN-methylpyridiniumyl)porphyrins (n = 2, 3, 4) and their binding modes to supercoiled DNA
Nataraj Chitrapriya, Jongjin Park, Wei Wang, Hyosun Lee and Seog K. Kim
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20015E

Metallomics, Issue 5, 2012, Inside front coverWe travel to Brazil for our inside front cover this month, with an image from Frédéric Frézard from Universidade Federal de Minas Gerais. Together with co-workers he has been looking at antimonial drugs, drugs which contain antimony, in the treatment of leishmaniasis. This is a type of parasitic disease caused by kinetoplastid protozoa which belong to the genus Leishmania.

Greater binding affinity of trivalent antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins
Frédéric Frézard, Heveline Silva, Adriano Monteiro de Castro Pimenta, Nicholas Farrell and Cynthia Demicheli
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT00176D

50 Years of Metals in Biology: the Gordon Research Conference

Metals in Biology Gordon Research Conference

These cover articles will be free to access for 6 weeks, so why not click through and take a look.

This month we also have a lovely Editorial by Richard H. Holm and Michael J. Maroney from the 2012 Metals in Biology Gordon Research Conference which was held January 22–27, in Ventura, CA, USA. As well as the scientific program, the conference celebrated the 50th anniversary of the very first meeting.

50 Years of Metals in Biology: the Gordon Research Conference
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT90017C

Issue 5 also has a minireview by Bei Wu and J. Sabine Becker from the Central Division of Analytical Chemistry, Forschungszentrum Jülich, Germany. In it they cover the emerging techniques for elemental imaging and speciation analysis that allows researchers to obtain increasing knowledge of elemental distribution and availabilities in plants.

Imaging techniques for elements and element species in plant science
Bei Wu and J. Sabine Becker
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT00002D

Finally, we also have a HOT article for you to read. Hugues Preud’homme and colleagues from the Université de Pau et des Pays de l’Adour, France, have studied selenium-rich yeasts as there is growing evidence of the superiority of organic forms of selenium over selenate or selenite in terms of bioaccessibility.

Large-scale identification of selenium metabolites by online size-exclusion-reversed phase liquid chromatography with combined inductively coupled plasma (ICP-MS) and electrospray ionization linear trap-Orbitrap mass spectrometry (ESI-MSn)
Hugues Preud’homme, Johann Far, Sandra Gil-Casal and Ryszard Lobinski
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT00172A

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Issue 4 online: covers and HOT articles

The latest issue of Metallomics is now available online for you to browse.  Featuring zinc biology, phytoremediating plants, Drosophila and metal oxide nanoparticles.

Metallomics, 2012, Issue 4, Oustide front cover

Biesemeier et al.

On the front cover is research from Antje Biesemeier and Oliver Eibl of the University of Tuebingen and colleagues, who studied the effects of zinc deficiency on the structure and elemental composition of the eye in Long Evans rats. This work was performed using analytical electron microscopy.

A low zinc diet leads to loss of Zn in melanosomes of the RPE but not in melanosomes of the choroidal melanocytes
Antje Biesemeier, Sylvie Julien, Despina Kokkinou, Ulrich Schraermeyer and Oliver Eibl
Metallomics, 2012, 4, 323-332
DOI: 10.1039/C2MT00187J

Metallomics, 2012, Issue 4, Inside front cover

Lyubenova et al.

The inside front cover features work from Lyudmila Lyubenova and Peter Schröder from Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, and colleagues who have studied the accumulation, localization and distribution of Pb and other mineral nutrients in the plant Typha latifolia, by using micro-PIXE. What they discovered is that this plant has the potential to remove Pb from surrounding contaminated sources, i.e. soil and water, due to its large root and rhizome surface area.

Localization and quantification of Pb and nutrients in Typha latifolia by micro-PIXE
Lyudmila Lyubenova, Paula Pongrac, Katarina Vogel-Mikuš, Gašper Kukec Mezek, Primož Vavpetič, Nataša Grlj, Peter Kump, Marijan Nečemer, Marjana Regvar, Primož Pelicon and Peter Schröder
Metallomics, 2012, 4, 333-341
DOI: 10.1039/C2MT00179A

These cover articles will be free to access for 6 weeks, so why not click through and take a look!

We also have two HOT articles for you to take a look at;

Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family?
Sílvia Pérez-Rafael, Antje Kurz, Maria Guirola, Mercè Capdevila, Òscar Palacios and Sílvia Atrian
Metallomics, 2012, 4, 342-349
DOI: 10.1039/C2MT00182A

Association of the physical and chemical properties and the cytotoxicity of metal oxide nanoparticles: metal ion release, adsorption ability and specific surface area
Masanori Horie, Katsuhide Fujita, Haruhisa Kato, Shigehisa Endoh, Keiko Nishio, Lilian Kaede Komaba, Ayako Nakamura, Arisa Miyauchi, Shinichi Kinugasa, Yoshihisa Hagihara, Etsuo Niki, Yasukazu Yoshida and Hitoshi Iwahashi
Metallomics, 2012, 4, 350-360
DOI: 10.1039/C2MT20016C

This month we also have some contributions from our Metallomics Advisory Board members Al Crumbliss and Marco Arruda!

Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport
Sambuddha Banerjee, Claire J. Parker Siburt, Shreni Mistry, Jennifer M. Noto, Patrick DeArmond, Michael C. Fitzgerald, Lisa A. Lambert, Cynthia N. Cornelissen and Alvin L. Crumbliss
Metallomics, 2012, 4, 361-372
DOI: 10.1039/C2MT20037F

Improving metallomics information related to transgenic and non-transgenic soybean seeds using 2D-HPLC-ICP-MS and ESI-MS/MS
Lidiane Raquel Verola Mataveli, Mariana Fioramonte, Fabio César Gozzo and Marco Aurélio Zezzi Arruda
Metallomics, 2012, 4, 373-378
DOI: 10.1039/C2MT00186A

A low zinc diet leads to loss of Zn in melanosomes of the RPE but not in melanosomes of the choroidal melanocytes

Antje Biesemeier, Sylvie Julien, Despina Kokkinou, Ulrich Schraermeyer and Oliver Eibl

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Issue 3 online: covers and HOT articles

Front cover of Metallomics, Volume 4, Issue 3

Front cover: Qiu et al., Metallomics, 2012, 4, 244-252

The latest issue of Metallomics is now available online for you to browse.  Featuring gouty arthritis, orange-based fluorophores, Helicobacter pylori and platinum-peptide conjugates.

On the front cover is research from Wei Jia of the University of North Carolina at Greensboro and colleagues, who show that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.
 

(more…)

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Take a look at Issue 2: now online

Metallomics, 2012, Issue 2, front cover

Front cover: Giannozzi et al.

The latest issue of Metallomics has just gone online, so why not take a look?

On the front cover, Giovanni La Penna (National Research Council Institute, Chemistry of Organometallic Compounds, Italy) and colleagues use X-ray absorption spectroscopy experimental data with detailed first-principle molecular dynamics simulations to look at configurations of zinc ions complexed with β-amyloid (Aβ) peptide.

It is known that Aβ is the main proteinaceous component of the amyloid brain deposits seen in patients suffering from Alzheimer’s disease, and that an increased concentration of transition metals is also found in these plaques.  Greater understanding of the relationship between Aβ and these metals is, therefore, of considerable interest.

Zn induced structural aggregation patterns of β-amyloid peptides by first-principle simulations and XAS measurements
Paolo Giannozzi, Karl Jansen, Giovanni La Penna, Velia Minicozzi, Silvia Morante, Giancarlo Rossi and Francesco Stellato
Metallomics, 2012
DOI: 10.1039/C2MT00148A

You may also be interested in our themed issue on Metals in Neurodegenerative Diseases, guest edited by David Brown of the University of Bath.

Metallomics, 2012, Issue 2, inside front cover

Inside front cover: Zhang et al.

On the inside front cover, Xiaolong Xu and colleagues from the University of Science and Technology of China look at the role of Cu2+ in the stabilisation of NAD-glycohydrolase (AA-NADase) from the venom of the pit viper Agkistrodon acutus.  It is also known as the ‘hundred-pace snake’, which refers to a local belief that, after being bitten, the victim will only be able to walk 100 steps before dying.  AA-NADase from Agkistrodon acutus venom is a unique multicatalytic enzyme with both NADase and AT(D)Pase-like activities.

Cu(II)- and disulfide bonds-induced stabilization during the guanidine hydrochloride- and thermal-induced denaturation of NAD-glycohydrolase from the venom of Agkistrodon acutus
Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Yan Zhang, Dengke Shen, Lili Peng and Jiajia Song
Metallomics, 2012
DOI: 10.1039/C1MT00135C

Both these papers will be free to access for 6 weeks.

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Issue 1 of 2012 now online

Metallomics 2012, Issue 1 front cover

On the front cover: Silva et al., Metallomics, 2012, 4, 37-47

Happy New Year!  We hope you enjoyed the festive season and wish you all the best for the year ahead.  Metallomics is back with its first issue of 2012, including some excellent cover articles.

The front cover features work from Lígia O. Martins, Isabel Bento and their colleagues from Universidade Nova de Lisboa (New University of Lisbon), Portugal.  They have characterised a recombinant multicopper oxidase from Campylobacter jejuni (McoC), providing evidence for the enzyme’s function as a metallo-oxidase.

Crystal structure of the multicopper oxidase from the pathogenic bacterium Campylobacter jejuni CGUG11284: characterization of a metallo-oxidase
Catarina S. Silva, Paulo Durão, Amanda Fillat, Peter F. Lindley, Lígia O. Martins and Isabel Bento
Metallomics, 2012, 4, 37-47
DOI: 10.1039/C1MT00156F

The inside front cover is a Communication from Eugenio Garribba of the University of Sassari and colleagues who have studied the interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum by EPR spectroscopy, pH-potentiometry and DFT calculations.  You can find out more here, and read the paper in full using the link below.

Metallomics 2012, Issue 1 inside front cover

On the inside front cover: Sanna et al., Metallomics, 2012, 4, 33-36

Communication: Biotransformation of BMOV in the presence of blood serum proteins
Daniele Sanna, Linda Bíró, Péter Buglyó, Giovanni Micera and Eugenio Garribba
Metallomics, 2012, 4, 33-36
DOI: 10.1039/C1MT00161B

Both these cover articles are free to access for 6 weeks, so please take a look and let your colleagues know.

Also in this issue is a HOT article from Manuel Aureliano, of Universidade do Algarve (University of Algarve), Portugal, and his collaborators.  Their Minireview compares the effects of vanadyl, vanadate and decavanadate on actin structure and function.

Minireview: Recent advances into vanadyl, vanadate and decavanadate interactions with actin
S. Ramos, J. J. G. Moura and M. Aureliano
Metallomics, 2012, 4, 16-22
DOI: 10.1039/C1MT00124H

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Issue 12 online: themed issue from ISM 2011

ISM 2011The final issue of 2011 is now online, and it features papers from the Third International Symposium on Metallomics, held in Germany in June.

Michael Sperling introduces the issue in his Editorial:

Editorial: The Third International Symposium on Metallomics 2011
Metallomics, 2011, 3, 1263-1264
DOI: 10.1039/C1MT90053F

Metallomics 2011, Issue 12 cover

Metallomics, 2011, 3(12): 1255-1386

Featured on the front cover is an article from Anthony White of the University of Melbourne and colleagues, who look at the sub-cellular localisation and neuroprotective action of the copper complex CuII(atsm).

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm)
Katherine Ann Price, Peter J. Crouch, SinChun Lim, Brett M. Paterson, Jeffrey R. Liddell, Paul S. Donnelly and Anthony R. White
Metallomics, 2011, 3, 1280-1290
DOI: 10.1039/C1MT00092F

Thank you to all our cover authors this year, and we look forward to bringing you more excellent images in 2012!

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Themed issue on Metal Toxicity published

Metallomics 2011, Issue 11 covers

Metallomics, 2011, 3(11): 1083-1254

Our themed issue on Metal Toxicity is now online!  Guest Edited by Chris Rensing of the University of Arizona and Gregor Grass of the Bundeswehr Institute of Microbiology, this issue contains a collection of reviews and research papers on an important and sometimes controversial topic.

Chris and Gregor introduce the issue in their Editorial:

Metal toxicity
Gregor Grass, Ludger Rensing and Christopher Rensing
DOI: 10.1039/C1MT90048J

The front cover of the issue features a Minireview from Oded Lewinson and Joshua Klein of the Technion-Israel Institute of Technology, Haifa, Israel.  They look at bacterial ATP-driven transporters of transition metals and discuss how each system is adapted to perform its specific task from mechanistic and structural perspectives.  Despite the differences, there is one important commonality: in many clinically relevant bacterial pathogens, transporters of transition metals are essential for virulence.

Minireview: Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
Joshua S. Klein and Oded Lewinson
DOI: 10.1039/C1MT00073J

Featured on the inside front cover is a Critical Review from Raymond Turner and colleagues from the University of Calgary, Alberta, Canada which explains the ‘-omics’ approach of metabolomics and how it can be applied to study a physiological response to toxic metal exposure.  A frank evaluation of the approach is given to provide newcomers to the method a clear idea of the challenges and the rewards of applying metabolomics to their research.

Critical Review: Metabolomics and its application to studying metal toxicity
Sean C. Booth, Matthew L. Workentine, Aalim M. Weljie and Raymond J. Turner
DOI: 10.1039/C1MT00070E

The cover articles will be free for 6 weeks, and do take a look at the full themed issue.

We’d like to thank the Guest Editors and all the authors for their contribution to putting the issue together, and we hope that you enjoy reading it.

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