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Zakel et al., Metallomics, 2012, 4, 1239

For this last issue of 2012 we have two lovely covers for you to enjoy. The colourful front cover comes from Sabine Zakel and colleagues at the Physikalisch-Technische Bundesanstalt in Germany. They have been studying the iron status in human serum, as this is an important diagnostic marker for a number of conditions such as anemia and hemochromatosis.

Reference measurement procedures for the iron saturation in human transferrin based on IDMS and Raman scattering
Claudia Frank, Olaf Rienitz, Reinhard Jährling, Detlef Schiel and Sabine Zakel
Metallomics, 2012, 4, 1239-1244
DOI: 10.1039/C2MT20183F

Ugarte et al., Metallomics, 2012, 4, 1245

On the inside front cover we have an image from Marta Ugarte from University of Manchester and Manchester Royal Eye Hospital. With a team from across the UK and Spain they have been looking at trace elements in the retina of rats and the varying distributions of the elements in different parts of the retina.

Concentration of various trace elements in the rat retina and their distribution in different structures
Marta Ugarte, Geoffrey W. Grime, Gillian Lord, Kalotina Geraki, Joanna F. Collingwood, Mary E. Finnegan, Hannah Farnfield, Michael Merchant, Melanie J. Bailey, Neil I. Ward, Peter J. Foster, Paul N. Bishop and Neville N. Osborne
Metallomics, 2012, 4, 1245-1254
DOI: 10.1039/C2MT20157G

We have a bumper four covers for this month’s issue of Metallomics!

Hutcheson & Broderick, Metallomics, 2012, 4, 1149

On the outside front cover comes an informative image from Rachel U. Hutcheson and Joan B. Broderick, Montana State University, and their minireview on radical SAM enzymes in methylation and methylthiolation. They present recent highlights in the understanding of radical SAM enzymes.

Radical SAM enzymes in methylation and methylthiolation
Rachel U. Hutcheson and Joan B. Broderick
Metallomics, 2012, 4, 1149-1154
DOI: 10.1039/C2MT20136D

Matzanke, Carrano et al., Metallomics, 2012, 4, 1160

On the inside front cover we have a beautiful image from Berthold F. Matzanke and Carl J. Carrano, University of Lubeck and San Diego State University, respectively, who have been looking at iron transport and storage in marine plant-like organisms.

Iron transport and storage in the coccolithophore: Emiliania huxleyi
Andrej Hartnett, Lars H. Böttger, Berthold F. Matzanke and Carl J. Carrano
Metallomics, 2012, 4, 1160-1166
DOI: 10.1039/C2MT20144E

Broberg et al., Metallomics, 2012, 4, 1167

On the inside back cover we showcase work by Karin Broberg in the Department of Laboratory Medicine at Lund University, Sweden and colleagues at the Karolinska Institutet, Stockholm and the Department of Risk Benefit Assessment, Uppsala, Sweden, and the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. They have been looking at environmental arsenic exposure and DNA methylation of the tumour suppressor gene p16 and the DNA repair gene MLH1.

Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype
Mohammad Bakhtiar Hossain, Marie Vahter, Gabriela Concha and Karin Broberg
Metallomics, 2012, 4, 1167-1175
DOI: 10.1039/C2MT20120H

Koellensperger et al., Metallomics, 2012, 4, 1176

And finally, on the outside back cover we find research into selenium enriched yeast products by Gunda Koellensperger at the University of Natural Resources and Life Sciences, Vienna, Austria and colleagues at the BIOMIN Research Center in Tulln, Austria.

Monitoring the production process of selenized yeast by elemental speciation analysis
Evelyn Rampler, Stephan Rose, Dominik Wieder, Anja Ganner, Ilse Dohnal, Thomas Dalik, Stephan Hann and Gunda Koellensperger
Metallomics, 2012, 4, 1176-1184
DOI: 10.1039/C2MT20138K

All of these cover articles will be free to read for 6 weeks.

Front cover: Aitken et al., Metallomics, 2012, 4, 1051-1056

There are two colourful covers on the latest issue of Metallomics, highlighting the imaging of ruthenium in cells and the prediction of crosslinked protein cofactors.

On the front cover, Hugh Harris of the University of Adelaide, Australia, and his international collaborators use X-ray fluorescence imaging at two incident energies was used to reveal the intracellular distribution of ruthenium in single human cells.

They show that synchrotron-based XRF is capable of detecting intracellular ruthenium and can provide valuable insight into the metabolic pathway of ruthenium-based drugs.

Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
Jade B. Aitken, Sumy Antony, Claire M. Weekley, Barry Lai, Leone Spiccia and Hugh H. Harris
Metallomics , 2012, 4, 1051-1056
DOI: 10.1039/C2MT20072D

On the inside front cover, David Benson from Calvin College, USA, and co-workers present a chemical bioinformatics method for the prediction of undiscovered crosslinked protein cofactors.

Inside front cover: Martinie et al., Metallomics, 2012, 4, 1037-1042

The authors say their approach provides the first step in developing high throughput methods for the discovery of proteins that form crosslinked protein cofactors in vivo.

Identifying proteins that can form tyrosine-cysteine crosslinks
Ryan J. Martinie, Pahan I. Godakumbura, Elizabeth G. Porter, Anand Divakaran, Brandon J. Burkhart, John T. Wertz and David E. Benson
Metallomics , 2012, 4, 1037-1042
DOI: 10.1039/C2MT20093G

Both these cover article will be free to access for 6 weeks, and don’t forget to take a look at the other highlights from this issue, including HOT articles and an Editorial from the new Chair of our Editorial Board.

Grasso et al., Metallomics, 2012, 4, 937

This months issue of Metallomics features papers from our Emerging Investigators themed issue and has three wonderful covers for you to enjoy.

On the front is a striking image from Giuseppe Grasso, Maria Laura Giuffrida and Enrico Rizzarelli who have written a critical review on the three main different pathways by which metal ions can affect the proteolytic enzymes responsible for Aβ peptides degradation.

Metallostasis and amyloid β-degrading enzymes
Giuseppe Grasso, Maria Laura Giuffrida and Enrico Rizzarelli
Metallomics, 2012, 4, 937-949
DOI: 10.1039/C2MT20105D

Lim & Storr et al, Metallomics, 2012, 4, 910

On the inside front cover we have an image from Emerging Investigators Mi Hee Lim and Tim Storr from the University of Michigan and the Simon Fraser University, respectively, who have been studying neurodegenerative diseases and metal-induced amyloid-β (Aβ) aggregation. Together with colleagues from the US and Canada, they have been looking at dual-function triazole–pyridine derivatives that can act as inhibitors to this Aβ aggregation.

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation
Michael R. Jones, Erin L. Service, John R. Thompson, Michael C. P. Wang, Isaac J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy, Mi Hee Lim and Tim Storr
Metallomics, 2012, 4, 910-920
DOI: 10.1039/C2MT20113E

Finney et al., Metallomics, 2012, 4, 921

We also have a lovely back cover this month. Showcasing research by Emerging Investigator Lydia Finney into the role of metals and metalloproteins in biological systems at the X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, USA.

Identifying metalloproteins through X-ray fluorescence mapping and mass spectrometry
Daniel Raimunda, Tripti Khare, Carol Giometti, Stefan Vogt, José M. Argüello and Lydia Finney
Metallomics, 2012, 4, 921-927
DOI: 10.1039/C2MT20095C

All of these papers will be free to access for 6 weeks, so click through and take a look!

You also might like to take a look at our Emerging Investigators themed issue and read about some of the hottest new research in the field.

Front cover: Bourassa and Miller, Metallomics, 2012,4, 721-738

The latest issue of Metallomics is now online, with not one, not two but four covers:

Our colourful front cover features an article from Lisa Miller of the National Synchrotron Light Source at Brookhaven National Laboratory (New York, USA) and her Ph.D. student at Stony Brook University, Megan Bourassa. Their Critical Review highlights the advances in neurodegenerative disease research facilitated by metal imaging techniques.

Critical Review: Metal imaging in neurodegenerative diseases
Megan W. Bourassa and Lisa M. Miller
Metallomics, 2012, 4, 721-738
DOI: 10.1039/C2MT20052J

The inside front cover comes from Martin Stillman and colleagues at Western University, London, Canada. They look at the effects of metal and ring periphery substitution in the Isd protein system involved in heme transport in the pathogenic bacterium Staphylococcus aureus.

Insight into blocking heme transfer by exploiting molecular interactions in the core Isd heme transporters IsdA-NEAT, IsdC-NEAT, and IsdE of Staphylococcus aureus
Michael T. Tiedemann,  Tyler B. J. Pinter and Martin J. Stillman
Metallomics, 2012, 4, 751-760
DOI: 10.1039/C2MT20067H

Inside front cover: Tiedemann et al., Metallomics, 2012, 4, 751-760

On the inside back cover, a paper from Christophe Biot and co-workers at the University of Lille, who used two ruthenocenic bioprobes to study the mechanism of the antimalarial drug candidate ferroquine.

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes
Christophe Biot,  Faustine Dubar,  Jamal Khalife and Christian Slomianny
Metallomics, 2012, 4, 780-783
DOI: 10.1039/C2MT20063E

And finally, on the outside back cover, Ruth Valentine and colleagues at Newcastle University present new information on the functional activity of the zinc transporter ZnT10.

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis
Helen J. Bosomworth,  Jared K. Thornton,  Lisa J. Coneyworth,  Dianne Ford and Ruth A. Valentine
Metallomics, 2012, 4, 771-779
DOI: 10.1039/C2MT20088K

All these cover articles will be free to access for 6 weeks – enjoy!

Back covers: Biot et al. (L) and Bosomworth et al. (R)

Issue 7 of Metallomics is a special themed issue on Metals and Genetics. It features papers originating from the Fifth International Conference on Metals and Genetics (ICMG) held in Kobe, Japan, September 4–8, 2011. Read more about this themed issue in the wonderful introductory Editorial by Bibudhendra Sarkar.

Sarkar et al., Metallomics, 2012, 4, 653

Metals and Genetics
Bibudhendra Sarkar
Metallomics, 2012, 4, 589-592
DOI: 10.1039/C2MT90030K

We have four wonderful covers for you to admire in this themed issue. On the outside front cover we have an image from our editorial author Bibudhendra Sarkar from The Hospital for Sick Children, Toronto, Canada, who has been working with colleagues from Canada and the US in studying drinking water in West Bengal, India.

A survey of arsenic, manganese, boron, thorium, and other toxic metals in the groundwater of a West Bengal, India neighbourhood
Thomas Bacquart, Kelly Bradshaw, Seth Frisbie, Erika Mitchell, George Springston, Jeffrey Defelice, Hannah Dustin and Bibudhendra Sarkar
Metallomics, 2012, 4, 653-659
DOI: 10.1039/C2MT20020A

Burkhead et al., Metallomics, 2012, 4, 660

The inside front cover has an image from Jason L. Burkhead at the University of Alaska Anchorage and a team from around the US working on Wilson’s disease which is an inherited recessive disorder that causes defective copper metabolism in the human body.

A systems approach implicates nuclear receptor targeting in the Atp7b^−/− mouse model of Wilson’s disease
Phillip A. Wilmarth, Kristopher K. Short, Oliver Fiehn, Svetlana Lutsenko, Larry L. David and Jason L. Burkhead
Metallomics, 2012, 4, 660-668
DOI: 10.1039/C2MT20017A

Ben-Tal & Lutsenko et al., Metallomics, 2012, 4, 669

On the inside back cover we have more research into Wilson’s disease by Nir Ben-Tal and Svetlana Lutsenko from Tel-Aviv University and Johns Hopkins University, respectively, who together with co-workers have been studying the copper-transporting ATPase ATP7B.

A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism
Maya Schushan, Ashima Bhattacharjee, Nir Ben-Tal and Svetlana Lutsenko
Metallomics, 2012, 4, 669-678
DOI: 10.1039/C2MT20025B

Bierbach et al., Metallomics, 2012, 4, 645

To round out the collection of covers, on the outside back cover we have an image from Ulrich Bierbach from Wake Forest University, US, and colleagues who have been studying lung cancer cells, and looking at DNA damage produced by a platinum–acridine antitumor agent.

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells
Xin Qiao, Alexandra E. Zeitany, Marcus W. Wright, Amal S. Essader, Keith E. Levine, Gregory L. Kucera and Ulrich Bierbach
Metallomics, 2012, 4, 645-652
DOI: 10.1039/C2MT20031G

These cover papers will be free to read for 6 weeks. As you can see, it’s a bumper collection this month in Metallomics, so take a look at our themed issue on Metals and Genetics today!

Hadjikakou et al., Metallomics, 2012, 4, 545

Issue 6 of Metallomics is now online for you to look at. This months issue features nanopore analysis, pharmacology, Pt complexes and more. Take a look while the articles are free to read.

On the front cover is a colourful image from Greece, where S. K. Hadjikakou from the University of Ioannina and colleagues have been working with mixed ligand-silver(I) complexes with anti-inflammatory agents.

Mixed ligand–silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis
C. N. Banti, A. D. Giannoulis, N. Kourkoumelis, A. M. Owczarzak, M. Poyraz, M. Kubicki, K. Charalabopoulos and S. K. Hadjikakou
Metallomics, 2012, 4, 545-560
DOI: 10.1039/C2MT20039B

Ballihaut et al., Metallomics, 2012, 4, 533

The inside front cover features research from the National Institute of Standards and Technology in the USA. Guillaume Ballihaut and colleagues have been studying the different forms of selenoprotein P, a rather unique protein in the human body responsible for the transport and distribution of the essential trace element selenium.

Multiple forms of selenoprotein P in a candidate human plasma standard reference material
Guillaume Ballihaut, Lisa E. Kilpatrick, Eric L. Kilpatrick and W. Clay Davis
Metallomics, 2012, 4, 533-538
DOI: 10.1039/C2MT20059G

Krasniqi & Lee, Metallomics, 2012, 4, 539

We have a back cover this month too! On the back of issue 6 you can find out about the research in nanopore analysis of proteins that is being conducted by Jeremy Lee and his colleagues at the University of Saskatchewan, Canada.

The importance of adding EDTA for the nanopore analysis of proteins
Besnik Krasniqi and Jeremy S. Lee
Metallomics, 2012, 4, 539-544
DOI: 10.1039/C2MT20050C

Other papers that you can read in the issue this month include;

Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect
Jane A. Plumb, Balaji Venugopal, Rabbab Oun, Natividad Gomez-Roman, Yoshiyuki Kawazoe, Natarajan Sathiyamoorthy Venkataramanan and Nial J. Wheate
Metallomics, 2012, 4, 561-567
DOI: 10.1039/C2MT20054F

Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES)
Matthew D. Hall, Helen L. Daly, Jenny Z. Zhang, Mei Zhang, Rebecca A. Alderden, Daniel Pursche, Garry J. Foran and Trevor W. Hambley
Metallomics, 2012, 4, 568-575
DOI: 10.1039/C2MT20053H

Front cover: Giannozzi et al.

The latest issue of Metallomics has just gone online, so why not take a look?

On the front cover, Giovanni La Penna (National Research Council Institute, Chemistry of Organometallic Compounds, Italy) and colleagues use X-ray absorption spectroscopy experimental data with detailed first-principle molecular dynamics simulations to look at configurations of zinc ions complexed with β-amyloid (Aβ) peptide.

It is known that Aβ is the main proteinaceous component of the amyloid brain deposits seen in patients suffering from Alzheimer’s disease, and that an increased concentration of transition metals is also found in these plaques.  Greater understanding of the relationship between Aβ and these metals is, therefore, of considerable interest.

Zn induced structural aggregation patterns of β-amyloid peptides by first-principle simulations and XAS measurements
Paolo Giannozzi, Karl Jansen, Giovanni La Penna, Velia Minicozzi, Silvia Morante, Giancarlo Rossi and Francesco Stellato
Metallomics, 2012
DOI: 10.1039/C2MT00148A

You may also be interested in our themed issue on Metals in Neurodegenerative Diseases, guest edited by David Brown of the University of Bath.

Inside front cover: Zhang et al.

On the inside front cover, Xiaolong Xu and colleagues from the University of Science and Technology of China look at the role of Cu²⁺ in the stabilisation of NAD-glycohydrolase (AA-NADase) from the venom of the pit viper Agkistrodon acutus.  It is also known as the ‘hundred-pace snake’, which refers to a local belief that, after being bitten, the victim will only be able to walk 100 steps before dying.  AA-NADase from Agkistrodon acutus venom is a unique multicatalytic enzyme with both NADase and AT(D)Pase-like activities.

Cu(II)- and disulfide bonds-induced stabilization during the guanidine hydrochloride- and thermal-induced denaturation of NAD-glycohydrolase from the venom of Agkistrodon acutus
Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Yan Zhang, Dengke Shen, Lili Peng and Jiajia Song
Metallomics, 2012
DOI: 10.1039/C1MT00135C

Both these papers will be free to access for 6 weeks.