Author Archive

Zinc ruled out as biomarker for Alzheimer’s disease

The role of zinc in Alzheimer’s disease (AD) is a much debated topic and the potential of zinc as an AD biomarker has come under scrutiny in recent years. Now scientists in Australia have added to evidence that no change in serum zinc concentration is seen in AD, and that decreasing zinc levels are instead a sign of ageing.

AD, the most common form of dementia, affects millions of people worldwide, and with limited treatments available, much effort is being devoted towards new therapies and early diagnosis. The identification of AD biomarkers in the blood is an attractive goal for researchers developing new diagnostic tools, and given its potential implications in the disease, zinc appeared to be a good candidate. However, conflicting studies appear in the literature, with significance increases, decreases, as well as no significant changes, all being reported.

To read the full article by Kirsty Muirhead, please visit Chemistry World

Decreased serum zinc is an effect of ageing and not Alzheimer’s disease
Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush and Blaine R. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00060A, Communication

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Conference: Brain Iron Accumulation in Neurological Diseases & Its Removal by Iron Chelation

Brain Iron Accumulation in Neurological Diseases & Its Removal by Iron Chelation
(London Iron Metabolism Group)

Wednesday 21st May 2014 14:00-18:30

King’s College London
Franklin Wilkins Building, Classroom 3.52,
Stamford Street, London. SE1 9NH

Chairs: A McKie & D. Dexter

Program

14:00-14:30 David Dexter (Imperial College London, UK)
A pilot efficacy and safety study with Deferiprone in Parkinson’s disease.

14:30-15:00 Joanna Collingwood (University of Warwick, UK)
Iron determinations in post-mortem brain and utilising MRI in Parkinson’s related disorders.

15:00-15:30 David Devos (Lille University, France)
Targeting chelatable iron as a therapeutic option in the treatment of Parkinson’s Disease.

15:30-16:00 Tea

16:00-16:30 John Connelly & Michael Spino (ApoPharma Inc, Canada)
The hydroxypyridinone dosing dilemma in neurodegeneration.

16:30-17:00 James Duce (University of Leeds, UK)
Role of APP in iron metabolism and neurodegeneration.

17:00-17:30 Kailash Bhatia (Institute of Neurology, University College London, UK)
Pathophysiology of neurodegeneration with brain iron accumulation (NBIA).

18:00 General Discussion

To reserve your place please contact: Andy McKie (Andrew.mckie@kcl.ac.uk)

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Cu binding by the Escherichia coli metal-efflux accessory protein RcnB
Camille Blériot, Manon Gault, Erwan Gueguen, Pascal Arnoux, David Pignol, Marie-Andrée Mandrand-Berthelot and Agnès Rodrigue
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00036F, Paper

Leaf metallome preserved over 50 million years
N. P. Edwards, P. L. Manning, U. Bergmann, P. L. Larson, B. E. van Dongen, W. I. Sellers, S. M. Webb, D. Sokaras, R. Alonso-Mori, K. Ignatyev, H. E. Barden, A. van Veelen, J. Anné, V. M. Egerton and R. A. Wogelius Graphical abstract: Leaf metallome preserved over 50 million years
Metallomics, 2014,6, 774-782
DOI: 10.1039/C3MT00242J, Paper

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells
Sabine H. van Rijt, Isolda Romero-Canelón, Ying Fu, Steve D. Shnyder and Peter J. Sadler
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00034J, Paper

Decreased serum zinc is an effect of ageing and not Alzheimer’s disease
Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush and Blaine R. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00060A, Communication

A variety of roles for versatile zinc in metallo-β-lactamases
A. I. Karsisiotis, C. F. Damblon and G. C. K. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00066H, Critical Review Graphical abstract: Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells

Metallomics of two microorganisms relevant to heavy metal bioremediation reveal fundamental differences in metal assimilation and utilization
W. Andrew Lancaster, Angeli Lal Menon, Israel Scott, Farris L. Poole, Brian J. Vaccaro, Michael P. Thorgersen, Jil Geller, Terry C. Hazen, Richard A. Hurt, Steven D. Brown, Dwayne A. Elias and Michael W. W. Adams
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00050A, Paper

In vitro toxicological characterisation of three arsenic-containing hydrocarbons
S. Meyer, M. Matissek, S. M. Müller, M. S. Taleshi, F. Ebert, K. A. Francesconi and T. Schwerdtle
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00061G, Paper

Zinc’ing sensibly: controlling zinc homeostasis at the transcriptional level
Sangyong Choi and Amanda J. Bird
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00064A, Critical Review

To view these article for free, please register for a free RSC account here

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Metallomics

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy! Graphical abstract: Challenging conventional wisdom: single domain metallothioneins

Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes
Zhaoyong Xi, Wei Guo, Changlin Tian, Fuyi Wang and Yangzhong Liu
Metallomics, 2014,6, 491-497
DOI: 10.1039/C3MT00338H, Paper

Challenging conventional wisdom: single domain metallothioneins
Duncan E. K. Sutherland and Martin J. Stillman
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00216K, Critical Review

Arsenic-induced suppression of kidney cell proliferation and the transcriptional coregulator MAML1
A. Pournara, T. Holmlund, Y. Lu, R. Ceder, M. Putnik, R. Grafström, M. Vahter and A. E. Wallberg
Metallomics, 2014,6, 498-504
DOI: 10.1039/C3MT00333G, Paper

An integrated study of the affinities of the Aβ16 peptide for Cu(I) and Cu(II): implications for the catalytic production of reactive oxygen species
Tessa R. Young, Angie Kirchner, Anthony G. Wedd and Zhiguang Xiao
Metallomics, 2014,6, 505-517
DOI: 10.1039/C4MT00001C, Paper Graphical abstract: A dual-targeting, p53-independent, apoptosis-inducing platinum(ii) anticancer complex, [Pt(BDIQQ)]Cl

A dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDIQQ)]Cl
Kogularamanan Suntharalingam, Justin J. Wilson, Wei Lin and Stephen J. Lippard
Metallomics, 2014,6, 437-443
DOI: 10.1039/C3MT00364G, Paper

Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I)
Jens Brose, Sharon La Fontaine, Anthony G. Wedd and Zhiguang Xiao
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00020J, Paper

Unravelling mechanisms behind the biological activity of bis(S-citronellalthiosemicarbazonato)nickel(II)
Annamaria Buschini, Silvana Pinelli, Rossella Alinovi, Francesca Mussi, Franco Bisceglie, Claudio Rivetti, Nicola Doniselli and Giorgio Pelosi
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00345K, Paper

Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots
Fany Doustaly, Florence Combes, Julie B. Fiévet, Serge Berthet, Véronique Hugouvieux, Olivier Bastien, Iker Aranjuelo, Nathalie Leonhardt, Corinne Rivasseau, Marie Carrière, Alain Vavasseur, Jean-PierrGraphical abstract: Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana rootse Renou, Yves Vandenbrouck and Jacques Bourguignon
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00005F, Paper

Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity
Asuncion Carmona, Stéphane Roudeau, Laura Perrin, Giulia Veronesi and Richard Ortega
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00012A, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Top ten most accessed Metallomics articles from October to December 2013

During the months October – December, the following articles were the top ten most accessed:

A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin
Kogularamanan Suntharalingam, Oscar Mendoza, Alexandra A. Duarte, David J. Mann and Ramon Vilar
Metallomics, 2013,5, 514-523
DOI: 10.1039/C3MT20252F, Paper

Selenium biochemistry and its role for human health
Marco Roman, Petru Jitaru and Carlo Barbante
Metallomics, 2014,6, 25-54
DOI: 10.1039/C3MT00185G, Critical Review

Recent developments in ruthenium anticancer drugs
Aviva Levina, Anannya Mitra and Peter A. Lay
Metallomics, 2009,1, 458-470
DOI: 10.1039/B904071D, Critical Review

Zinc-selective inhibition of the promiscuous bacterial amide-hydrolase DapE: implications of metal heterogeneity for evolution and antibioticdrug design
Narasimha Rao Uda, Grégory Upert, Gaetano Angelici, Stefan Nicolet, Tobias Schmidt, Torsten Schwede and Marc Creus
Metallomics, 2014,6, 88-95
DOI: 10.1039/C3MT00125C, Paper

Comparative proteomics analysis of sodium selenite-induced apoptosis in human prostate cancer cells
Ping Chen, Lixiang Wang, Na Li, Qiong Liu and Jiazuan Ni
Metallomics, 2013,5, 541-550
DOI: 10.1039/C3MT00002H, Paper

The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro
Alfred A. Hummer and Annette Rompel
Metallomics, 2013,5, 597-614
DOI: 10.1039/C3MT20261E, Tutorial Review

An overview of heavy metal challenge in plants: from roots to shoots
Giovanni DalCorso, Anna Manara and Antonella Furini
Metallomics, 2013,5, 1117-1132
DOI: 10.1039/C3MT00038A, Minireview

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics
J. Sabine Becker, Andreas Matusch, Christoph Palm, Dagmar Salber, Kathryn A. Morton and J. Susanne Becker
Metallomics, 2010,2, 104-111
DOI: 10.1039/B916722F, Perspective

Transition metals in plant photosynthesis
Inmaculada Yruela
Metallomics, 2013,5, 1090-1109
DOI: 10.1039/C3MT00086A, Minireview

Molecular mechanism of intestinal iron absorption
Okhee Han
Metallomics, 2011,3, 103-109
DOI: 10.1039/C0MT00043D, Minireview

If you have any thoughts or comments on any of these articles, we welcome you to leave these in the comment box below.

Fancy submitting to Metallomics? Why not submit to us here or alternatively email us with your suggestions.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free HOT articles in Metallomics!

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next four weeks. Enjoy!

Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors
Òscar Palacios, Anna Espart, Jordi Espín, Chen Ding, Dennis J. Thiele, Sílvia Atrian and Mercè Capdevila
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00266G, Paper

Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells
Julio A. Landero Figueroa, Kavitha Subramanian Vignesh, George S. Deepe and Joseph Caruso
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00283G, Paper

A different sequence of events than previously reported leads to arsenic-induced damage in Ceratophyllum demersum L.
Seema Mishra, Hans-Joachim Stärk and Hendrik Küpper
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00317E, Paper

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans
Julia Bornhorst, Sudipta Chakraborty, Sören Meyer, Hanna Lohren, Sigrid Große Brinkhaus, Adam L. Knight, Kim A. Caldwell, Guy A. Caldwell, Uwe Karst, Tanja Schwerdtle, Aaron Bowman and Michael Aschner
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00325F, Paper

Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle
Héctor Gonzalez-Iglesias, Lydia Alvarez, Montserrat García, Carson Petrash, Alfredo Sanz-Medel and Miguel Coca-Prados
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00298E, Perspective

Proteomics of Desulfovibrio desulfuricans and X-ray absorption spectroscopy to investigate mercury methylation in the presence of selenium
Hoang-Yen Thi Truong, Yu-Wei Chen, Mazen Saleh, Susan Nehzati, Graham N. George, Ingrid J. Pickering and Nelson Belzile
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00323J, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

The Emerging Technologies competition open for applications

The Royal Society of Chemistry launches the 2014 UK Emerging Technologies Competition

Applications are invited from university researchers and small companies working in the UK in applied research in the chemical, life and materials sciences for a chance to turn their research into commercial success. The prize consists of ongoing mentoring and support from high profile multinational companies, up to £10,000 cash prize and more. We are proud to announce the mentor companies Procter and Gamble, GlaxoSmithKline, Catalent Applied Drug Delivery Institute, Croda and more will be joining soon.

Emerging Technologies Competition 2014

The applicants can be individuals or teams and they must submit a brief online application to the Royal Society of Chemistry. The entries will be judged by an independent panel of science and business experts and the shortlisted applications will be invited for the second round of the competition. Each team will pitch to a specialist panel at a public event and up to 5 teams will be crowned as winners. But everyone is a winner! The finalists will be able to access one to one FREE advice from business and finance specialists. In addition this is an excellent opportunity to practice pitching ideas to high profile multinational companies and to meet and network with fellow entrepreneurs, investors and business leaders.

Key dates:
First round closes on 1 March 2014
Second round takes place on 25 June 2014,
Chemistry Centre, London

Visit www.rsc.li/emerging-technologies for full details.
UK applications only please

If you have any questions please contact Aurora Antemir antemira@rsc.org.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Prizes and Awards nominations now open

The Royal Society of Chemistry’s Prizes and Awards recognise achievements by individuals, teams and organisations in advancing the chemical sciences. There are over 80 Prizes and Awards available covering all areas of the chemical sciences, with prize money of up to £5000 to be won.

The main categories are:

shutterstock_93666160

Biosciences

Environment, Sustainability and Energy

Inorganic Chemistry (Dalton Division)

Materials Chemistry

Organic Chemistry

Physical Chemistry (Faraday Division)

Industry & Technology

In addition, we have a new award this year, the Industrial Analytical Science Award, to recognise and celebrate the great contribution of analytical science in industry.

To view the full list of Prizes and Awards and to make a nomination, visit www.rsc.org/awards

Nominations open until 15 January 2014

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free HOT articles in Metallomics!

Take a look at our selected HOT articles just published in Metallomics: these papers will be free to read for the next three weeks. Enjoy!

Phylogenomic analysis of Cation Diffusion Facilitator proteins uncovers Ni2+/Co2+ transporters
Ciro Cubillas, Pablo Vinuesa, Maria Luisa Tabche and Alejandro García-de los Santos
Metallomics, 2013,5, 1634-1643
DOI: 10.1039/C3MT00204G, Paper

Intracellular co-delivery of zinc ions and plasmid DNA for enhancing gene transfection activity
Shoichiro Asayama, Kosho Matsuda, Yoichi Negishi and Hiroyoshi Kawakami
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00226H, Paper

Metal sensing and signal transduction by CnrX from Cupriavidus metallidurans CH34: role of the only methionine assessed by a functional, spectroscopic, and theoretical study
Juliette Trepreau, Cornelia Grosse, Jean-Marie Mouesca, Géraldine Sarret, Eric Girard, Isabelle Petit-Haertlein, Sandra Kuennemann, Céline Desbourdes, Eve de Rosny, Antoine P. Maillard, Dietrich H. Nies and Jacques Covès
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00248A, Paper

Distribution of trace elements in the mammalian retina and cornea by use of particle-induced X-ray emission (PIXE): localisation of zinc does not correlate with that of metallothioneins
Marta Ugarte, Geoffrey W. Grime and Neville N. Osborne
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00271C, Paper

Zinc to cadmium replacement in the prokaryotic zinc-finger domain
Gaetano Malgieri, Maddalena Palmieri, Sabrina Esposito, Vincenzo Maione, Luigi Russo, Ilaria Baglivo, Ivan de Paola, Danilo Milardi, Donatella Diana, Laura Zaccaro, Paolo Vincenzo Pedone, Roberto Fattorusso and Carla Isernia
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00208J, Paper

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function
Su Ling Leong, Tessa R. Young, Kevin J. Barnham, Anthony G. Wedd, Mark G. Hinds, Zhiguang Xiao and Roberto Cappai
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00258F, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)