Editor’s Choice: Chris Orvig selects his top papers from recent issues of Metallomics

Metallomics Editorial Board Member, Professor Chris Orvig (University of British Columbia) selects his Top 5 articles from recent issues of Metallomics.

Professor Orvig is Director of the Medicinal Inorganic Chemistry Group and Professor of Chemistry and Pharmaceutical Sciences at the University of British Columbia. His research interests are medicinal inorganic chemistry and coordination chemistry and he has been involved over the years with radiopharmaceutical chemistry, metal ion decorporation, and metal ion neurotoxicology, as well as chemotherapeutic metal complexes and ligands.

Read Professor Orvig’s Editor’s Choice selection via the links below – all articles are free to access for the next 4 weeks!

The role of vanadium in biology

Dieter Rehder, Metallomics, 2015, 7, 730, DOI: 10.1039/c4mt00304g

A timely and comprehensive review, from one of the world’s experts, on relevant bioinorganic chemistry of vanadium, an element of many roles and even more questions.  The review highlights the many roles of vanadium in nature and biology, including its transport, speciation, redox, acquisition and natural sources, as well as medicinal applications.  A detailed readable and timely account.

Boron uptake, localization, and speciation in marine brown algae

Eric P. Miller et al., Metallomics, 2016, 8, 161, DOI: 10.1039/c5mt00238a

Boron’s marine concentrations exceed those in its terrestrial environments significantly and yet it is a required element throughout the plant kingdom.  This paper examines boron in two species of brown algae looking at uptake, localization, and speciation with a variety of physical techniques (including 11B NMR) concluding that it is bound to cell walls (possibly as alginate) and as mannitol esters.

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Stuart D. Portbury et al., Metallomics, 2016, 8, 193, DOI: 10.1039/c5mt00234f

An unusual study of the “metallo-pathological” features of traumatic brain injury including increased brain concentrations of non-heme Fe and free Zn.  The study examines regional and time point specific elevations in Fe, Zn and Cu that were detected immediately and up to 28 days after a controlled cortical impact; such an impact results in both significant and sustained alterations in normal metal levels in the brain. A brutal but fascinating study.

LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs

Sarah Theiner et al., Metallomics, 2016, 8, 398, DOI: 10.1039/c5mt00276a

An interesting proof-of-principle combination of a hyphenated mass spectrometry technique for elemental imaging with tumour spheroids, a useful macroscopic three dimensional cancer cell model, to examine Pt drug accumulation from three anti-tumour agents.  Excellent spatial resolution allowed imaging of Pt on the periphery and in the necrotic core of the spheroids, as well as estimations of drug penetration of the tumours.

Chemistry of bone remodelling preserved in extant and fossil Sirenia

Jennifer Anné et al., Metallomics, 2016, 8, 508, DOI: 10.1039/c5mt00311c

A combination of high energy X-ray techniques is used to characterise, localize and quantify trace elements (particularly Ca and Zn) within bone tissues of aquatic mammals (e.g. manatees). Their dense bone structure showed concentrations of the elements to be comparable whether extant or fossil material was studied suggesting distributions, concentrations, and chemical coordination of the elements indicate the chemistry of bone remodelling has been preserved for 19 million years.  A most unusual and potentially broad-reaching study.

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