Editor’s Choice: Yasumitsu Ogra selects his top papers from recent issues of Metallomics

Metallomics Editorial Board Member, Yasumitsu Ogra (Chiba University, Japan) selects his Top 5 articles from recent issues of Metallomics.

Yasumitsu Ogra is professor of the Department of Toxicology and Environmental Health, Chiba University, Chiba, Japan. His current research is devoted to toxicometallomics and the elucidation of mechanisms underlying physiological and toxicological effects of metals and metalloids.

Read Yasumitsu Ogra’s Editor’s Choice selection via the links below – all articles are free to access for the next 4 weeks!

A novel arsenic methyltransferase gene of Westerdykella aurantiaca isolated from arsenic contaminated soil: phylogenetic, physiological, and biochemical studies and its role in arsenic bioremediation

Shikha Verma et al., Metallomics, 2016, 8, 344, DOI:10.1039/C5MT00277J

The authors identify a novel arsenic methyltransferase from a soil fungus. The methyltransferase mainly converts inorganic arsenicals such as arsenite arsenate to volatile methylated arsenic species. The observation may be useful for bioremediation of arsenic-contaminated soil.

Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

J. E. J. Hardyman et al., Metallomics, 2016, 8, 337, DOI:10.1039/C5MT00305A

Metal-responsive transcription factor 1 (MTF-1) is known as a transcription factor sensing an intracellular zinc concentration. In this paper, some gene expressions are indirectly controlled by MTF-1 via the expressions of metallothioneins and an efflux transporter of zinc (ZnT-1) which are directly regulated by MTF-1.

Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury

Vincent Perrot et al., Metallomics, 2016, 8, 170, DOI:10.1039/C5MT00286A

The authors reveal the metabolism of methylmercury in marine mammals by the analysis of precise isotopic ratio of mercury. This approach is unique to clarify the detoxification of methylmercury.

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Dominic J. Hare et al., Metallomics, 2016, 8, 156, DOI:10.1039/C5MT00288E

The authors demonstrate the multi-elemental imaging in C. elegans by X-ray fluorescence microscopy. This technique is expected to be widely applicable for biology in metals.

The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2)

Cheng-Yu Tsai et al., Metallomics, 2015, 7, 1477, DOI:10.1039/C5MT00131E

There are two copper influx transporters in mammalian cells, CTR1 and CTR2. The authors clearly show that the defection of CTR1 reduces the stability of CTR2 protein. This is the first paper revealing the direct interaction between two copper influxers involved in copper homeostasis.

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