Rachel is a bioinorganic chemist and her laboratory has a longstanding interest in understanding the mechanisms of metalloenzymes, especially those important in the global cycling of elements.
Below, see what Rachel says about each of the articles she has selected – all articles are free to access for the next 4 weeks!*
Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans
Michael Aschner et. al., Metallomics, 2015, 7, 847–856, DOI: 10.1039/C5MT00052A
An interesting hypothesis, namely that increased Mn accumulation in worms lacking pdr-1, a parkin homolog, is due to changes in Mn transport was tested in this paper. The authors found evidence that Mn export is reduced in worms without pdr-1, consistent with the idea that metal ion imbalance is connected to Parkinsonism.
Synthesis of nickel–iron hydrogenase in Cupriavidus metallidurans is controlled by metal-dependent silencing and un-silencing of genomic islands
Dietrich H. Nies et. al., Metallomics, 2015, 7, 632–649, DOI: 10.1039/C4MT00297K
This paper presents a series of complementary experiments highlighting connections between zinc homeostasis and the expression of nickel-dependent proteins.
Back to the metal age: battle for metals at the host–pathogen interface during urinary tract infection
Harry L. T. Mobley et. al., Metallomics, 2015, 7, 935–942, DOI: 10.1039/C4MT00329B
Any bioinorganic chemist who has ever watched the havoc UTIs cause in the elderly will find this summary of metal-dependent host-pathogen interactions a very satisfying article to read.
Proteomic analysis of the copper resistance of Streptococcus pneumoniae
Xuesong Sun et. al., Metallomics, 2015, 7, 448–454, DOI: 10.1039/C4MT00276H
Two dimensional electrophoresis coupled with mass spectrometry and quantitative reverse transcription PCR point to the importance of cell wall biosynthesis in the defense response of Streptococcus pneumonia to elevated levels of copper.
Understanding metal homeostasis in primary cultured neurons. Studies using single neuron subcellular and quantitative metallomics
Robert A. Colvin et. al., Metallomics, 2015, 7, 1111–1123, DOI: 10.1039/C5MT00084J
A beautiful paper highlighting the power of synchrotron radiation X-ray fluorescence (SRXRF) to provide quantitative information about the metal distribution within a single cell and to compliment knowledge about in vivo metal ion localization gleaned from other types of measurements