Natalia Szenkier-Garcia from the Weizmann Institute of Science in UK recently won the Metallomics Poster Prize at the 12th International Symposium on Metal Ions in Biology and Medicine held in Punte del Este, Uruguay.
In her work, Natalia explored the chemical, biochemical and biological aspects of proteasome inhibitory activity of thiosemicarbazate-copper complexes.
The proteasome is a large protein present in eukaryotes and Archaea responsible for the regulation of multiple physiological functions and an established target of anticancer drugs. The long-term goal of this research is to identify metal-complexes that can influence the proteasome activity and act as therapeutic agents in multiple myeloma.
Interested in metal-based compounds?
Here are some papers that you might be intersted in. They will be free to read until April 12th. Click on the links below:
Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin
Michael Groessl , Olivier Zava and Paul J. Dyson
Metallomics, 2011,3, 591-599
DNA binding and nucleolytic properties of Cu(II) complexes of salicylaldehyde semicarbazones
Wan Yen Lee , Yaw Kai Yan , Peter Peng Foo Lee , Shiow Jin Tan and Kok Hwa Lim
Metallomics, 2012,4, 188-196
Advances in metal–carbene complexes as potent anti-cancer agents
Arnaud Gautier and Federico Cisnetti
Metallomics, 2012,4, 23-32