Iron regulation by small bacterial RNAs


An interesting review on iron regulation by small RNAs has been just published in Metallomics by Amanda Oglesby-Sherrouse and Erin Murphy, from the University of Maryland, USA.

Mechanisms of gene regulation dependent by the small RNA RyhB

Small RNAs are non-encoding RNA molecules produced by bacteria and involved in a variety of cellular processes. One of these is RyhB, identified in 2002 and shown to be involved in iron regulation mediated by the protein Fur. In iron rich environments, Fur binds iron molecules activating RyhB which in turn regulates gene expression. When iron is scarce, Fur does not bind iron and RyhB remains inactive. Bacteria need iron to survive and replicate in the environment they live in. However, excessive iron leads to production of reactive oxygen species and can be harmful for the bacteria.

In this review, the authors highlight how the newly discovered sRNA regulators can affect the lifestyle of bacteria by increasing or decreasing iron uptake. To know more about iron regulation by small RNAs, please access the full article below. It will be free to read until February 21st.

Iron-responsive bacterial small RNAs: variations on a theme
Amanda G. Oglesby-Sherrouse and Erin R. Murphy
Metallomics, 2013, Advance Article
DOI: 10.1039/C3MT20224K

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