Metallomics Issue 2 NOW online!

Accumulation of Zn and Co in lung cells

The second issue of Metallomics is finally online with two new covers for you to enjoy.

On the outside front cover, images showcase a study from France by Carole Bresson and her group. The team underlines the toxicity of cobalt chloride determining its speciation and cytotoxicity. Herein, they observe accumulation of cobalt and zinc in pulmonary cells by using direct in situ micro-chemical analysis based on ion micro-beam techniques and describe the synergistic toxicity of combined cobalt and zinc exposure in human cells.

Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc
Carole Bresson ,  Carine Darolles ,  Asuncion Carmona ,  Céline Gautier ,  Nicole Sage ,  Stéphane Roudeau ,  Richard Ortega ,  Eric Ansoborlo and Véronique Malard
Metallomics, 2013, 5, 133-143
DOI: 10.1039/C3MT20196A

Effect of MPTP on metal concentration

Our inside front cover features an interesting review written by Dominc James Hare and colleagues from the University of Technology, Sydney. The authors examine the unbalanced metal concentration observed during Parkinson’s disease. In addition, they analyse how cellular metabolism is altered following release of MPTP, a potent toxin that selectively destroys dopaminergic neurons in the substantia nigra. The use of MPTP as a model for Parkinson’s disease is also discussed.

Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
Dominic J. Hare ,  Paul A. Adlard ,  Philip A. Doble and David I. Finkelstein
Metallomics, 2013, 5, 91-109
DOI: 10.1039/C2MT20164J

Alog with our new covers, here are two selected HOT papers for you free to read until February 18thFiona Larner examines copper metabolism during Parkinson’s disease and Jose Arguello analyses copper transport during infection with Pseudomonas. To know more about these studies, please access the full articles by clicking the links below:

High precision isotope measurements reveal poor control of copper metabolism in Parkinsonism
F. Larner ,  B. Sampson ,  M. Rehkämper ,  D. J. Weiss ,  J. R. Dainty ,  S. O’Riordan ,  T. Panetta and P. G. Bain
Metallomics, 2013, 5, 125-132
DOI: 10.1039/C3MT20238K

Periplasmic response upon disruption of transmembrane Cu transport in Pseudomonas aeruginosa
Daniel Raimunda ,  Teresita Padilla-Benavides ,  Stefan Vogt ,  Sylvain Boutigny ,  Kaleigh N. Tomkinson ,  Lydia A. Finney and José M. Argüello
Metallomics, 2013, 5, 144-151
DOI: 10.1039/C2MT20191G

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