Quantitative proteomics for metal toxicity

This study shows the toxic effects of nickel (Ni) and cobalt (Co) in the soil bacterium Pseudomonas putida by quantitative proteomics. Ni and Co are metals present in the environment derived from natural sources or industrial use. Due to their extensive use in metallurgy, considerable amounts of Ni and Co are found in the aquatic environment or in solid waste composts.

Effect of Ni and Co on the gorwth of Pseudomonas putida

Agnes Rodrigue and colleagues from the University of Lyon describe the harmful effects of Ni and Co in P. putida and unveil the specific response of bacteria to each metal. They observe that while Co induces accumulation of proteins involved in the defense against oxidative stress, Ni increases accumulation of both superoxide radicals and proteins involved in the biosynthesis of amino acids.

To read the full article free for you until January 24th click on the link below:

Pseudomonas putida KT2440 response to nickel or cobalt induced stress by quantitative proteomics
Prasun Ray, Vincent Girard, Manon Gault, Claudette Job, Marc Bonneu, Marie-Andrée Mandrand-Berthelot, Surya S. Singh, Dominique Job and Agnès Rodrigue
Metallomics, 2013, 5, 68-79
DOI: 10.1039/C2MT20147J

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