With the boom of the past years in the area of genomics culminated with the sequencing of the entire human genome, we are now entering the post-genomics era.
Researchers now think that predictions of calcium-binding sites based on the amino acid sequences translated from nucleotide sequences will greatly improve our knowledge of the role of calcium in biological systems. Calcium is the most abundant mineral present in the human body and binds to a myriad of cellular proteins affecting many aspects of cellular life. Calciomics is the term used to indicate a specialised area of biochemistry that studies calcium binding macromolecules and proteins. In this minireview, Jenny Yang and her group from the Georgia State University, USA, explore this area, describing all the steps necessary to identify calcium-binding proteins starting from the protein amino acid sequence.
The authors predict that the new rational protein design based on computational analysis will provide us with proteins useful for diagnostic and therapeutic purposes.
To read the full article, click on the link below. It is free for you to read until January 9th.
Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems
Yubin Zhou , Shenghui Xue and Jenny J. Yang
Metallomics, 2013,5, 29-42