What’s HOT in Issue 10?

Nickel uptake in Escherichia coli

HOT article: Chivers et al., Metallomics, 2012, 4, 1043-1050

Take a look at these HOT articles, which feature in the latest issue of Metallomics.

In their Critical Review, Joseph Cotruvo Jr. and JoAnne Stubbe of MIT, Cambridge, USA, summarise the diversity of ways in which iron and manganese are substituted in similar or identical protein frameworks*

Critical Review: Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study
Joseph A. Cotruvo, Jr and JoAnne Stubbe
, 2012, 4, 1020-1036
DOI: 10.1039/C2MT20142A

Peter Chivers and colleagues at Washington University School of Medicine, St. Louis, USA, identify the first nickel complex, Ni-(L-His)2, that is imported by microbes. The authors say this should allow more focused studies of the molecular recognition of nickel ions in the environment by organisms that require them for growth.

Identification of Ni-(L-His)2 as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli
Peter T. Chivers, Erin L. Benanti, Vanessa Heil-Chapdelaine, Jeffrey S. Iwig and Jessica L. Rowe
, 2012, 4, 1043-1050
DOI: 10.1039/C2MT20139A

Michael Linscheid of Humboldt University Berlin, Germany, and collaborators present a methodology to measure the complex adduct spectrum caused by the interaction of Cisplatin with in vivo DNA. The complementary use of molecular and elemental mass spectrometry, say the authors, provides new options to characterize and understand the biological consequences of the wide variety of detected Cisplatin–DNA adducts.

On the complexity and dynamics of in vivo Cisplatin–DNA adduct formation using HPLC/ICP-MS
Matthias Ziehe, Diego Esteban-Fernández, Ulrike Hochkirch, Jürgen Thomale and Michael W. Linscheid
, 2012, 4, 1098-1104
DOI: 10.1039/C2MT20128C

These HOT articles will be free to access until 12 October – don’t forget to take a look at the covers for Issue 10 too.

Dr Wolfgang Maret

Metallomics Editorial Board Chair, Dr Wolfgang Maret

Also in this issue, an Editorial from the new Chair of our Editorial Board, Dr Wolfgang Maret of King’s College London, and Editor, Dr May Copsey. They look at the history of the field of metallomics, future opportunities for development and how the journal aims to support all researchers investigating the role of metals in the biological sciences.

Metallomics: whence and whither
, 2012, 4, 1017-1019
DOI: 10.1039/C2MT90041F

Follow Metallomics on Twitter: @metallomics

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