Issue 10 online

Metallomics, 2012, Vol. 4, Issue 10, front cover

Front cover: Aitken et al., Metallomics, 2012, 4, 1051-1056

There are two colourful covers on the latest issue of Metallomics, highlighting the imaging of ruthenium in cells and the prediction of crosslinked protein cofactors.

On the front cover, Hugh Harris of the University of Adelaide, Australia, and his international collaborators use X-ray fluorescence imaging at two incident energies was used to reveal the intracellular distribution of ruthenium in single human cells.

They show that synchrotron-based XRF is capable of detecting intracellular ruthenium and can provide valuable insight into the metabolic pathway of ruthenium-based drugs.

Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
Jade B. Aitken, Sumy Antony, Claire M. Weekley, Barry Lai, Leone Spiccia and Hugh H. Harris
, 2012, 4, 1051-1056
DOI: 10.1039/C2MT20072D

On the inside front cover, David Benson from Calvin College, USA, and co-workers present a chemical bioinformatics method for the prediction of undiscovered crosslinked protein cofactors.

Metallomics, 2012, Vol. 4, Issue 10, inside front cover

Inside front cover: Martinie et al., Metallomics, 2012, 4, 1037-1042

The authors say their approach provides the first step in developing high throughput methods for the discovery of proteins that form crosslinked protein cofactors in vivo.

Identifying proteins that can form tyrosine-cysteine crosslinks
Ryan J. Martinie, Pahan I. Godakumbura, Elizabeth G. Porter, Anand Divakaran, Brandon J. Burkhart, John T. Wertz and David E. Benson
, 2012, 4, 1037-1042
DOI: 10.1039/C2MT20093G

Both these cover article will be free to access for 6 weeks, and don’t forget to take a look at the other highlights from this issue, including HOT articles and an Editorial from the new Chair of our Editorial Board.

Follow Metallomics on Twitter: @metallomics

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