There are two colourful covers on the latest issue of Metallomics, highlighting the imaging of ruthenium in cells and the prediction of crosslinked protein cofactors.
On the front cover, Hugh Harris of the University of Adelaide, Australia, and his international collaborators use X-ray fluorescence imaging at two incident energies was used to reveal the intracellular distribution of ruthenium in single human cells.
They show that synchrotron-based XRF is capable of detecting intracellular ruthenium and can provide valuable insight into the metabolic pathway of ruthenium-based drugs.
Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
Jade B. Aitken, Sumy Antony, Claire M. Weekley, Barry Lai, Leone Spiccia and Hugh H. Harris
Metallomics , 2012, 4, 1051-1056
The authors say their approach provides the first step in developing high throughput methods for the discovery of proteins that form crosslinked protein cofactors in vivo.
Identifying proteins that can form tyrosine-cysteine crosslinks
Ryan J. Martinie, Pahan I. Godakumbura, Elizabeth G. Porter, Anand Divakaran, Brandon J. Burkhart, John T. Wertz and David E. Benson
Metallomics , 2012, 4, 1037-1042
Both these cover article will be free to access for 6 weeks, and don’t forget to take a look at the other highlights from this issue, including HOT articles and an Editorial from the new Chair of our Editorial Board.