On the front is a striking image from Giuseppe Grasso, Maria Laura Giuffrida and Enrico Rizzarelli who have written a critical review on the three main different pathways by which metal ions can affect the proteolytic enzymes responsible for Aβ peptides degradation.
On the inside front cover we have an image from Emerging Investigators Mi Hee Lim and Tim Storr from the University of Michigan and the Simon Fraser University, respectively, who have been studying neurodegenerative diseases and metal-induced amyloid-β (Aβ) aggregation. Together with colleagues from the US and Canada, they have been looking at dual-function triazole–pyridine derivatives that can act as inhibitors to this Aβ aggregation.
Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation
Michael R. Jones, Erin L. Service, John R. Thompson, Michael C. P. Wang, Isaac J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy, Mi Hee Lim and Tim Storr
Metallomics, 2012, 4, 910-920
We also have a lovely back cover this month. Showcasing research by Emerging Investigator Lydia Finney into the role of metals and metalloproteins in biological systems at the X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, USA.
Identifying metalloproteins through X-ray fluorescence mapping and mass spectrometry
Daniel Raimunda, Tripti Khare, Carol Giometti, Stefan Vogt, José M. Argüello and Lydia Finney
Metallomics, 2012, 4, 921-927
All of these papers will be free to access for 6 weeks, so click through and take a look!
You also might like to take a look at our Emerging Investigators themed issue and read about some of the hottest new research in the field.