HOT article: Changing iron content of the mouse brain during development

Lindahl et al., Metallomics, 2012, 4, 761

This research article is from Paul A. Lindahl’s group in collaboration with Louise C. Abbott from the Texas A & M University, College Station, USA. The research focuses on how the percentages of the major iron (Fe) containing species change during different stages of development in mice brain. The authors have enriched mice with 57Fe and have used Mossbauer spectroscopy, along with EPR, UV-vis, and ICP-MS, as biophysical probes of the types of Fe centers contained in the mouse brain and quantified the rates of Fe incorporation into the brain. The authors found that Fe is imported slowly into the brain, relative to the rate of import into other organs and also observed a stable organic radical EPR signal that increased with age, consistent with the ROS theory of aging. Click on the link below to read more.

Changing iron content of the mouse brain during development
Gregory P. Holmes-Hampton, Mrinmoy Chakrabarti, Allison L. Cockrell, Sean P. McCormick, Louise C. Abbott, Lora S. Lindahl and Paul A. Lindahl
Metallomics, 2012, 4, 761-770
DOI: 10.1039/C2MT20086D

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