Neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are defined by a gradual loss of neuronal cell populations and protein aggregation. Mi Hee Lim and Tim Storr, from the University of Michigan and Simon Fraser University, respectively, have been studying metal-induced amyloid-β (Aβ) aggregation. Together with colleagues they have been looking at dual-function triazole–pyridine derivatives that can act as inhibitors to this Aβ aggregation.
Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation
Michael R. Jones, Erin L. Service, John R. Thompson, Michael C. P. Wang, Isaac J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy, Mi Hee Lim and Tim Storr
Metallomics, 2012, Advance Article