Metal of the Month: Platinum

Platinum's anti-corrosive nature means it is often used in jewellery

In South America, the ancient Mayans used platinum in their jewellery long before it was ‘discovered’ by Europeans in the 18th century. It is a very rare heavy metal, the majority mined in South Africa, and as such is a major precious metal commodity on the stock market, often being more expensive than gold.

In modern times platinum is still used in jewellery due to it being very resistant to corrosion, but it is also used in industry as a catalyst, in catalytic converters in cars, in electronics, and laboratory equipment. Platinum is not known to have any biological role, however its compounds are used in chemotherapy treatments for some forms of cancer. It is this use as a metallodrug against tumors that is the focus of the majority of platinum papers in Metallomics.

To read some more about platinum, look below at some the papers we have published with Metallomics. They will be free to read for 3 weeks.

Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES)
Matthew D. Hall, Helen L. Daly, Jenny Z. Zhang, Mei Zhang, Rebecca A. Alderden, Daniel Pursche, Garry J. Foran and Trevor W. Hambley
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20053H

Catalytic converters use Pt to reduce toxic car emissions. Image credit: Ben Smith/Shutterstock.com

A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA
Masako Uemura, Yuko Yoshikawa, Masahiko Chikuma and Seiji Komeda
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20022H

An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles
Masako Uemura, Toshihiro Suzuki, Kazuto Nishio, Masahiko Chikuma and Seiji Komeda
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20026K

Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low side reaction
Yuji Wang, Guifeng Kang, Jiawang Liu, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Ye Li, Xiaobo Zhong, Yifan Yang and Shiqi Peng
Metallomics, 2012, 4, 441-447
DOI: 10.1039/C2MT00005A

Platinum compounds are used in chemotherapy

Synthesis and in vitro cytotoxicity of cis,cis,trans-diamminedichloridodisuccinatoplatinum(IV)–peptide bioconjugates
Luca Gaviglio, Annika Gross, Nils Metzler-Nolte and Mauro Ravera
Metallomics, 2012, 4, 260-266
DOI: 10.1039/C2MT00171C

Analytical methodologies for metallomics studies of antitumor Pt-containing drugs
Diego Esteban-Fernández, Estefanía Moreno-Gordaliza, Benito Cañas, María Antonia Palacios and María Milagros Gómez-Gómez
Metallomics, 2010, 2, 19-38
DOI: 10.1039/B911438F

Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(II) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage
Carolin Mügge, Elena Micheucci, Francesca Boscaro, Chiara Gabbiani, Luigi Messori and Wolfgang Weigand
Metallomics, 2011, 3, 987-990
DOI: 10.1039/C1MT00069A

Don’t forget you can find out more about platinum (and any other element) via the RSC Visual Elements Periodic Table – take a look!Follow Metallomics on Twitter: @metallomics

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