HOT Article: Studying Wilson’s disease

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson's disease

Burkhead et al., Metallomics, 2012, Advance Article

Jason L. Burkhead from the University of Alaska Anchorage, and a team from around the US have been studying Wilson’s disease, an inherited recessive disorder that is the result of a mutation in the ATP7B gene and causes defective copper metabolism in the human body. This leads to copper accumulation in tissues, leading to a number of neurological or psychiatric symptoms, and liver disease.

Click here or on the title below to read more about their research. This paper will be free to access for 2 weeks, so don’t delay!

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson’s disease
Phillip A. Wilmarth, Kristopher K. Short, Oliver Fiehn, Svetlana Lutsenko, Larry L. David and Jason L. Burkhead
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20017A

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