HOT Article: A highly antitumor-active platinum(II) complex

Seiji Komeda from the Suzuka University of Medical Science and other colleagues from Japan have been exploring  Pt–DNA interaction modes of Pt based anticancer drugs that are different from those of cisplatin. They performed kinetic and cytotoxicity studies on these new compounds. Click through here and check out their results. This HOT article will be free to access for 2 weeks.

Komeda et al., Metallomics, 2012, Advance Article

An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles
Masako Uemura, Toshihiro Suzuki, Kazuto Nishio, Masahiko Chikuma and Seiji Komeda
Metallomics, 2012, Advance Article
DOI: 10.1039/C2MT20026K

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Leave a Reply