Seiji Komeda from the Suzuka University of Medical Science and other colleagues from Japan have been exploring Pt–DNA interaction modes of Pt based anticancer drugs that are different from those of cisplatin. They performed kinetic and cytotoxicity studies on these new compounds. Click through here and check out their results. This HOT article will be free to access for 2 weeks.
An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles
Masako Uemura, Toshihiro Suzuki, Kazuto Nishio, Masahiko Chikuma and Seiji Komeda
Metallomics, 2012, Advance Article