Joan Soldevila from the University of Warwick recently won the Metallomics Poster Prize at the Dalton Division Joint Interest Groups Meeting, which was held at the University of Warwick in the first week of April.
His poster was entitled “NADH Regeneration by Ru(II) half sandwich complexes containing water soluble monotosylated ethylendiamine chelating ligands”. In it, the regioselective reduction of NAD+ to 1,4-NADH with ruthenium(II) arene complexes using ethylenediamine chelating ligands was studied and catalytic activity examined.
The goal of this research is to help design new ruthenium organometallic complexes that have the potential to act as catalytic therapeutic agents.
Here are some papers from Metallomics that you might be interested to read:
Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin
Michael Groessl, Olivier Zava and Paul J. Dyson
Metallomics, 2011, 3, 591-599
Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex
Kui Wu, Qun Luo, Wenbing Hu, Xianchan Li, Fuyi Wang, Shaoxiang Xiong and Peter J. Sadler
Metallomics, 2012, 4, 139-148
FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions
Marijana Petković and Tina Kamčeva
Metallomics, 2011, 3, 550-565
C– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma
Anna K. Bytzek, Katharina Boeck, Gerrit Hermann, Stephan Hann, Bernhard K. Keppler, Christian G. Hartinger and Gunda Koellensperger
Metallomics, 2011, 3, 1049-1055