Take a look at Issue 2: now online

Investigating zinc’s involvement with Alzheimer’s, and copper’s role in stabilising a snake venom enzyme.

Metallomics, 2012, Issue 2, front cover

Front cover: Giannozzi et al.

The latest issue of Metallomics has just gone online, so why not take a look?

On the front cover, Giovanni La Penna (National Research Council Institute, Chemistry of Organometallic Compounds, Italy) and colleagues use X-ray absorption spectroscopy experimental data with detailed first-principle molecular dynamics simulations to look at configurations of zinc ions complexed with β-amyloid (Aβ) peptide.

It is known that Aβ is the main proteinaceous component of the amyloid brain deposits seen in patients suffering from Alzheimer’s disease, and that an increased concentration of transition metals is also found in these plaques.  Greater understanding of the relationship between Aβ and these metals is, therefore, of considerable interest.

Zn induced structural aggregation patterns of β-amyloid peptides by first-principle simulations and XAS measurements
Paolo Giannozzi, Karl Jansen, Giovanni La Penna, Velia Minicozzi, Silvia Morante, Giancarlo Rossi and Francesco Stellato
Metallomics, 2012
DOI: 10.1039/C2MT00148A

You may also be interested in our themed issue on Metals in Neurodegenerative Diseases, guest edited by David Brown of the University of Bath.

Metallomics, 2012, Issue 2, inside front cover

Inside front cover: Zhang et al.

On the inside front cover, Xiaolong Xu and colleagues from the University of Science and Technology of China look at the role of Cu2+ in the stabilisation of NAD-glycohydrolase (AA-NADase) from the venom of the pit viper Agkistrodon acutus.  It is also known as the ‘hundred-pace snake’, which refers to a local belief that, after being bitten, the victim will only be able to walk 100 steps before dying.  AA-NADase from Agkistrodon acutus venom is a unique multicatalytic enzyme with both NADase and AT(D)Pase-like activities.

Cu(II)- and disulfide bonds-induced stabilization during the guanidine hydrochloride- and thermal-induced denaturation of NAD-glycohydrolase from the venom of Agkistrodon acutus
Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Yan Zhang, Dengke Shen, Lili Peng and Jiajia Song
Metallomics, 2012
DOI: 10.1039/C1MT00135C

Both these papers will be free to access for 6 weeks.

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