Our themed issue on Metals in Neurodegenerative Diseases is now online.
Guest Edited by Professor David R. Brown, this collection of articles highlights and reviews some of the work being carried out in this undoubtedly important, and sometimes controversial, area of research.
On the front cover: a study by Mi Hee Lim and colleagues reporting the framework of bifunctional small molecules that can target metal ions associated with amyloid-beta species.
Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation
Jung-Suk Choi, Joseph J. Braymer, Se Kyung Park, Shaik Mustafa, Junghyun Chae and Mi Hee Lim
Metallomics, 2011, 3, 284-291
On the inside front cover: a communication by Lucas and Lee looking at how copper(II) binding to the N-terminus of alpha-synuclein affects its helical propensity and affinity for lipid vesicles.
Communication: Copper(II) enhances membrane-bound α-synuclein helix formation
Heather R. Lucas and Jennifer C. Lee
Metallomics, 2011, 3, 280-283
Both these articles will be free until 18 April.
We hope you enjoy reading this themed issue and look forward to hearing your thoughts in the comments area below.