Archive for the ‘News’ Category

Outstanding Reviewers for MedChemComm in 2016

Following the success of Peer Review Week in September 2016 (dedicated to reviewer recognition) during which we published a list of our top reviewers, we will continue to recognise the contribution that our reviewers make to the journal by announcing our Outstanding Reviewers each year.

Outstanding Reviewers for MedChemComm in 2016, as selected by the editorial team, have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

A big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr Simone Carradori, University of Chieti-Pescara

Professor David A. Colby, University of Mississippi

Dr Abasaheb Dhawane, Georgia State University

Dr Zhang Jiancun, Chinese Academy of Sciences

Professor Zhengqui Li, Jinan University

Dr Xiaoyun Lu, Chinese Academy of Sciences

Dr Enas Malik, University of Bonn

Dr Sandeep Sundriyal, Imperial College London

Dr Kazuya Tatani, Kissei Pharmaceuticals Co. Ltd.

Dr Xu Yong, Chinese Academy of Sciences

We would also like to thank the MedChemComm boards and the medicinal chemistry community for their continued support of the journal, as authors, reviewers and readers.

If you would like to become a reviewer for our journal, just email us with details of your research interests and an up-to-date CV or résumé.  You can find more details in our author and reviewer resource centre

 

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Top 10 reviewers for MedChemComm

In celebration of Peer Review Week, with the theme around Recognition for Review – we would like to highlight the top 10 reviewers for MedChemComm in 2016, as selected by the editor for their significant contribution to the journal.

Name Institution
Dr Sandeep Sundriyal Imperial College London
Dr Abasaheb Dhawane Georgia State University
Dr Xiaoyun Lu Guangzhou Institute of Biomedicine and Health
Dr Kazuya Tatani Kissei Pharmaceutical Co., Ltd.
Dr Zhenqqiu Li Jinan University
Dr Enas Malik Rheinische Friedrich Wilhelms Universitat Bonn
Dr Yong Xu Guangzhou Institute of Biomedicine and Health, CAS
Dr Mingxuan Wu John Hopkins School of Medicine
Dr Yves Janin Institut Pasteur
Dr Oleg Tsodikov University of Kentucky

We would like to say a massive thank you to these reviewers as well as the MedChemComm Editorial and Advisory Boards and all of the Medicinal Chemistry community for their continued support of the journal, as authors, reviewers and readers.

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Updated guidelines and standards for MedChemComm

We’re about to publish our first new issue of 2016 and with it come some changes to the journal which we hope will enhance MedChemComm for our readers, authors and reviewers.

More detailed scope and significance guidelines
We’ve updated our scope and significance guidelines to provide more detail about the type of research we publish, to help authors decide if MedChemComm is the right journal for their article. Also we now ask authors to provide a very brief statement on submission of their article which describes why their research is a significant advance in their field. This information assists our editors and referees in assessing the article’s suitability for publication in the journal.

Introducing ‘Research Articles’
Primary research articles in MedChemComm, which were previously called ‘Concise Articles’, are now ‘Research Articles’. There’s no change in the length or style of articles; ‘Research Articles’ can accommodate any type of primary research article, including communication and full paper styles. The change in name is purely to better reflect this breadth of style. You’ll start seeing the new article name from issue 2 this year.

Article layout
One of the most important aspects of an article from a reader’s point of view is that it’s easy to find and read, with the key information readily available. Therefore we’ve updated guidelines on writing titles and abstracts, which gives advice on how to make these as impactful as possible. This is something we’ll now ask referees to comment on when assessing a manuscript. Also we’ll be limiting the amount of experimental detail included in the main text to two journal pages. Authors should still provide as much experimental information and data as is required for their research; however anything over the two pages should be included in the supplementary information rather than the main text.

Experimental information and data
It’s important that the research published in MedChemComm has the highest levels of integrity and reproducibility; therefore we’ve updated our guidelines on experimental information and data. These give authors information on how much experimental detail should be included, what data are required and the format in which they should be presented.

Feel free to send us any comments or suggestions about these changes or anything else to do with the journal. Thank you to all our authors, reviewers and readers for your continued support, and I hope you enjoy reading MedChemComm in 2016.

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2016 RSC Prizes and Awards in Organic Chemistry & Chemical Biology now open for nomination

The 2016 RSC Prizes and Awards are now open for nomination!

Nominations will close on 15 January 2016.


For more than 140 years, our Prizes and Awards programme has been acknowledging and celebrating exceptional talent in the chemical sciences, and with your support we are hoping that 2016 will even more successful!

Last year’s winners include Chemists such as Prof. Wilfred van der Donk (University of Illinois), Prof. Tim Donohoe (University of Oxford), Prof. Shuli You (Shanghai Institute of Organic Chemistry), Prof. Philip Gale (University of Southampton), Prof. Herman Overkleeft (Leiden University), Prof. Alison Ashcroft and Prof. Sheena Radford (University of Leeds).

This year we have 63 prizes and awards open for nominations of individuals, teams and organisations covering the breadth of the chemical sciences across academia, education and industry.

This year’s prizes in the field of Organic Chemistry & Chemical Biology include:

CBID (Chemistry Biology Interface Division) awards –

Organic Awards –

For 2016 our Longstaff Prize is also open – since 1881 we have awarded this prize once every three years to one of our members who has achieved the most to advance the science of chemistry.

Submit your suggestions now!

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Medicinal Chemistry Toolkit app v2.0 now released

FREE Medicinal Chemistry Toolkit App

Easy to access functions – anytime, anywhere

The Medicinal Chemistry Toolkit App, compatible with iOS devices and optimised for iPad, provides a suite of resources to support the day to day work of a medicinal chemist.

Search the App store forMedicinal Chemistry Toolkit.”

Functions include:
  • Cheng-Prusoff calculator
  • Dose to man calculator
  • Gibbs free energy to binding constant calculator
  • Maximum absorbable dose calculator
  • Potency shift due to plasma protein binding calculator
  • LogD vs pH curves
  • Attrition modeller
  • Drug-drug interaction modeller

Exciting new functionality recently released in v2.0 allows you to draw your own structures and provides direct feedback on  the quality or drug-like nature of your compound and calculates pharmacologically relevant properties (GClogP, ligand efficiency).

The Handbook of Medicinal Chemistry

The app has been designed in collaboration with the editors of The Handbook of Medicinal Chemistry: Principles and Practice, which was published in December 2014 providing a comprehensive, everyday resource for a practicing medicinal chemist throughout the drug development process.

Price: £84.99 – RSC Members receive 35% discount!

Order Now.

Print ISBN: 978-1-84973-625-1

Pages:  788

  • Comprehensive and up-to-date information covering the entire drug development process.
  • Written and edited by experts from academia and industry.
  • Case studies with hints and tips from within the industry allow medicinal chemists to apply academic understanding to drug discovery.

Coming Soon:  interactive electronic format

The Handbook will be published online to allow greater linking to relevant resources. Per chapter download from our publication platform containing additional features, such as links to protein and chemical structures, interactive graphs and downloadable project management templates, will be available soon.

  • PDF eISBN: 978-1-78262-183-6
  • EPUB eISBN: 978-1-78262-419-6
  • DOI: 10.1039/9781782621836
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Malcolm Campbell Memorial Prize winners 2015

The Biological and Medicinal Chemistry Sector of the Royal Society of Chemistry is proud to announce the winners of the Malcolm Campbell Memorial Prize for 2015. The prize has been awarded to Miles Congreve, Fiona Marshall and Malcolm Weir for the seminal contributions to G-protein-coupled receptor (GPCR) drug discovery made by Heptares Therapeutics Ltd since the company was founded in 2007.

This work has included building the world-renowned StaR© technology platform for X-ray crystallography of GPCRs and the invention of a number of clinical candidates. The winners are particularly commended on their outstanding publication record, and on their willingness to release data into the public domain.

The Malcolm Campbell Memorial prize commemorates Professor Campbell’s outstanding contributions in a broad range of chemistry and their applications to the understanding of bioactivity. The prize is awarded biennially and the 2015 prize will be presented formally to the winning team during the 18th RSC/SCI Medicinal Chemistry Symposium to be held at Churchill College in Cambridge on 13th to 16th September 2015.

The BMCS Committee wishes to express its gratitude for the high-quality entries from both academia and industry for the 2015 award.

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In the Pipeline articles from Derek Lowe now featured in MedChemComm

The new year brings a host of new features in MedChemComm. The first of these is that we are now featuring articles by medicinal chemist and blogger Derek Lowe. These articles, which give opinion and insight into both the science and business sides of drug discovery, will be selected from those published in his In the Pipeline column in the Royal Society of Chemistry magazine Chemistry World, bringing this content to a new audience.

Take a look at the first article in issue 1 of MedChemComm, and look out for further announcements about new features in MedChemComm through the year.

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Quinoxalines with biological activity

A recent publication in MedChemComm from Doaa A. E. Issa et al.reports the synthesis and biological properties of a series of compounds containing the quinoxaline pharmacophore. Their choice of the quinoxaline motif was inspired by the antineoplastic and antimicrobial activity of other compounds containing this group.

Issa et al. synthesised a total of 15 compounds via a key hydrazino intermediate and evaluated 10 candidates at a single high dose for antitumour activity in the National Cancer Institute-60 cell screen. Compounds showing activity were further evaluated in a multi-dose assay. The team went on to assess the in vitro antibacterial activity and antifungal properties.

They found that several compounds in the series display antibacterial activity and one compound possesses both broad spectrum anticancer activity and antimicrobial activity against Pseudomonas aeruginosa.

Two examples of bioactive quinoxalines

Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents
Doaa A. E. Issa, Nargues S. Habib and Abeer E. Abdel Wahab
Med. Chem. Commun., 2015, DOI: 10.1039/C4MD00257A

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Take 1…minute for chemistry in health

Can you explain the importance of chemistry to human health in just 1 minute? If you’re an early-career researcher who is up to the challenge, making a 1 minute video could win you £500.

The chemical sciences will be fundamental in helping us meet the healthcare challenges of the future, and we are committed to ensuring that they contribute to their full potential. As part of our work in this area, we are inviting undergraduate and PhD students, post-docs and those starting out their career in industry to produce an original video that demonstrates the importance of chemistry in health.

We are looking for imaginative ways of showcasing how chemistry helps us address healthcare challenges. Your video should be no longer than 1 minute, and you can use any approach you like.

The winner will receive a £500 cash prize, with a £250 prize for second place and £150 prize for third place up for grabs too.

Stuck for inspiration? Last year’s winning video is a good place to start. John Gleeson’s video was selected based on the effective use of language, dynamic style, creativity and its accurate content.

The closing date for entries to be submitted is 30 January 2015. Our judging panel will select the top five videos. We will then publish the shortlisted videos online and open the judging to the public to determine the winner and the runners up.

For more details on how to enter the competition and who is eligible, join us at the Take 1… page.

Good luck!

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RSC Organic Division Poster Symposium 2014

RSC Organic Division Poster Symposium 2014, headline sponsored by F. Hoffmann-La Roche, Ltd.

The poster symposium, for final year organic chemistry PhD students, will take place at The Royal Society of Chemistry, Burlington House, London on Monday 01 December 2014.

The symposium offers final year PhD students a chance to showcase their research to their peers, leading academics and industrial chemists, and is open to all branches of organic chemistry. The symposium has a tradition of being the most competitive and highly regarded organic chemistry symposium for PhD students in the UK and ROI and we would like to thank F. Hoffmann-La Roche, Ltd. for their generous support of the event.

There will be a first prize of £500, two runner-up prizes of £250, and a “selected by Industry Prize”. Industrial delegates will make this selection by considering the research’s potential for application in an industrial context; the winner will also receive a prize of £500.

Closing date for submissions is Wednesday 01 October 2014.
For more information and to submit your abstract go to http://rsc.li/organic-poster

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